Investigation of the Biochemical and Histological Changes Induced by Zearalenone Mycotoxin on Liver in Male Mice and the Protective Role of Crude Venom Extracted from Jellyfish &amp;lt;i&amp;gt;Cassiopea Andromeda&amp;lt;/i&amp;gt;

Al‐Seeni, Madeha N.; El-Sawi, Nagwa M.; Shaker, Soad; Al-Amoudi, Asma Abdulrahman

doi:10.4236/fns.2011.24045

Cited by 8 publications

(9 citation statements)

References 39 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Albumin levels increased in the experimental animals (Table 2). Al-Seeni et al (2011) also reported a temporary increase in albumin concentrations in zearalenone-induced mycotoxicosis. There are no published references to diseases that are accompanied by increased serum albumin levels.…”

Section: Discussionmentioning

confidence: 99%

“…There are no published references to diseases that are accompanied by increased serum albumin levels. Elevated albumin concentrations are generally attributed to dehydration resulting from decreased feed or water intake (Al-Seeni et al 2011). In view of the antioxidant properties of albumins and ZEN's ability to induce oxidative stress, an increase in albumin con-centrations could be part of the body's response to disturbance of the oxidative homeostasis (Abid-Essefi et al 2009, Tawerna et al 2013).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone

Jakimiuk¹,

Radwińska²,

Pomianowski³

et al. 2015

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Zearalenone (ZEN) widely contaminates animal feed of plant origin. The recommended safe concentrations of ZEN in feeds for various animal species are set mainly based on the mycotoxin's hormonal properties (NOEL). Our growing knowledge about biologically active concentrations of ZEN, molecular mechanisms and cells/tissues targeted by ZEN indicates that the harmful effects exerted by this mycotoxin on animals may be far greater than previously believed. This experiment was performed on pre-pubertal gilts divided into a control group (n=9) and an experimental group (ZEN, n=9). The control group received placebo, whereas the experimental group was administered ZEN at a dose of 0.1 mg/kg feed (equivalent to 5 μg/kg BW/day) for 42 days. On days 14, 28 and 42 blood samples were collected from the animals to determine the concentrations of selected zearalenols, serum biochemical and haematological parameters. Conjugated ZEN was found in the blood serum of the experimental gilts. Changes in the analysed biochemical parameters included a transient increase in albumin and cholesterol levels. A statistically significant increase in the concentrations of neutrophilic and acidophilic granulocytes was observed in the white blood cell system. The results indicate that long-term per os exposure of pre-pubertal gilts to low doses of ZEN (below NOEL) has a modulatory effect on liver function and white blood cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone

Jakimiuk¹,

Radwińska²,

Pomianowski³

et al. 2015

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Consequently, a continuing need exists for the development of reliable methods for the detection of these mycotoxins. A wide range of analytical methods is currently available for this purpose, including high-performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS), thinlayer chromatography (TLC), gas chromatography (GC) and enzyme-linked immunosorbent assays (ELISA) (10)(11)(12)(13). Furthermore, many common detection methods take advantage of the native fluorescence of OTA and ZEN (14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

The effects of pH and surfactants on the absorption and fluorescence properties of ochratoxin A and zearalenone

Kim

et al. 2015

Luminescence

View full text Add to dashboard Cite

The pH and surfactant dependencies of the absorption and fluorescence properties of ochratoxin A (OTA) and zearalenone (ZEN), the main mycotoxins found as contaminants in foods and feeds, were evaluated. Three surfactants with different ionic properties were investigated, namely sodium dodecyl sulfate (SDS, anionic), Tween 20 (nonionic) and hexadecyltrimethylammonium bromide (CTAB, cationic). The results show that the effects of pH on the absorption wavelength maxima and fluorescence efficiencies of the mycotoxins, which are a consequence of the presence of acidic phenol and/or carboxyl containing fluorophores, are dependent on the ionic nature of the added surfactants. Specifically, the fluorescence responses to pH changes of OTA and ZEN are similar in the presence or absence of Tween 20 and SDS. By contrast, the pH-dependent fluorescence properties of these mycotoxins are altered when CTAB is present in the solutions. Moreover, unlike OTA, ZEN in aqueous solution displays almost no fluorescence. However, fluorescence enhancement takes place when surfactants are present in aqueous solutions of this mycotoxin. The results of this study demonstrate that the different microenvironments, present in the organized micellar systems created by the individual surfactants, can be potentially employed to modulate the sensitivities and selectivities of the fluorescence detection of OTA or ZEN.

show abstract

“…ZEA has been implicated in reproductive disorders, as it can bind and activate estrogenic receptors [ 5 ]. ZEA has also shown multiple toxicities in the immune system [ 6 ], liver [ 7 ], and kidney [ 8 ]. In addition, it has carcinogenic potential [ 9 ] and enhances lipid peroxidation [ 10 ], which are most likely a result of its oxidative stress properties [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Proanthocyanidins Protect Epithelial Cells from Zearalenone-Induced Apoptosis via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis Pathways in Mouse Small Intestines

et al. 2018

View full text Add to dashboard Cite

This study evaluated the protective effect of proanthocyanidins (PCs) on reducing apoptosis in the mouse intestinal epithelial cell model MODE-K exposed to zearalenone (ZEA) through inhibition of the endoplasmic reticulum stress (ERS)-induced apoptosis pathway. Our results showed that PCs could reduce the rate of apoptosis in MODE-K cells exposed to ZEA (p < 0.01). PCs significantly increased the ZEA-induced antioxidant protective effects on the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and on the content of GSH. PCs also significantly decreased the ZEA-induced increase in the content of malondialdehyde (MDA). The analysis indicated that ZEA increased both mRNA and protein expression levels of C/EBP homologous protein (CHOP), GRP78, c-Jun N-terminal kinase (JNK), and cysteinyl aspartate specific proteinase 12 (caspase-12) (p < 0.05), which are related to the ERS-induced apoptosis pathway. ZEA decreased levels of the pro-apoptotic related protein Bcl-2 (p < 0.05) and increased the anti-apoptotic related protein Bax (p < 0.05). Co-treatment with PCs was also shown to significantly reverse the expression levels of these proteins in MODE-K cells. The results demonstrated that PCs could protect MODE-K cells from oxidative stress and apoptosis induced by ZEA. The underlying mechanism may be that PCs can alleviate apoptosis in mouse intestinal epithelial cells by inhibition of the ERS-induced apoptosis pathway.

show abstract

Investigation of the Biochemical and Histological Changes Induced by Zearalenone Mycotoxin on Liver in Male Mice and the Protective Role of Crude Venom Extracted from Jellyfish <i>Cassiopea Andromeda</i>

Abstract: Zearalenone (ZEN) is a non steroidal estrogenic mycotoxin produced by Fusarium species of fungi which contaminate human foods and animal feeds worldwide. In this study hepatotoxicity of ZEN was evaluated in mice by

Cited by 8 publications

References 39 publications

Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone

Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone

The effects of pH and surfactants on the absorption and fluorescence properties of ochratoxin A and zearalenone

Proanthocyanidins Protect Epithelial Cells from Zearalenone-Induced Apoptosis via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis Pathways in Mouse Small Intestines

Contact Info

Product

Resources

About