Prevention of adhesions in the temporomandibular joint by the use of chitosan membrane in goats

Li, H P; Sun, Shiqun; Fan, Bokai; Shen, Pei; Zheng, Jun; Zhang, S Y

doi:10.1016/j.bjoms.2016.08.017

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Many materials have been tested for TMJ disc replacement: (1) polyamide (Springer et al., 2001); (2) polyglycolic acid (PGA) (Wang et al., 2009); (3) flat discs of poly(glycerol sebacate) (PGS) (Chin et al., 2018); (4) polylactic acid (PLA) (Ahtiainen et al., 2013); (5) polytetrafluoroethylene (Lai et al., 2001); (6) silicone sheets (Hartman et al., 1988; Schliephake et al., 1999); (7) other biomaterials, such as collagen hydrogels and decellularized tissues (Brown et al., 2012; Li et al., 2017). However, none of these has progressed to clinical trials.…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled preclinical trial on 3 interposal temporomandibular joint disc implants: TEMPOJIMS—Phase 2

Ângelo

Wang

Morouço

et al. 2021

J Tissue Eng Regen Med

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The effort to develop an effective and safe temporomandibular joint (TMJ) disc substitute has been one of the mainstreams of tissue engineering. Biodegradable customized scaffolds could approach safety and effectiveness to regenerate a new autologous disc, rather than using non‐biodegradable materials. However, it is still technically challenging to mimic the biomechanical properties of the native disc with biodegradable polymers. In this study, new 3D tailored TMJ disc implants were developed: (1) Poly(glycerol sebacate) (PGS) scaffold reinforced with electrospun Poly(εcaprolactone) (PCL) fibers on the outer surface (PGS+PCL); (2) PCL and polyethylene glycol diacrylate (PEGDA) (PCL+PEGDA); and (3) PCL. The TMJ implants were tested in a randomized preclinical trial, conducted in 24 black Merino sheep TMJ, perfoming bilateral interventions. Histologic, imaging, and kinematics analysis was performed. No statistical changes were observed between the PGS+PCL disc and the control group. The PCL+PEGDA and PCL groups were associated with statistical changes in histology (p = 0.004 for articular cartilage mid‐layer; p = 0.019 for structure changes and p = 0.017 for cell shape changes), imaging (p = 0.027 for global appreciation) and dangerous material fragmentation was observed. No biomaterial particles were observed in the multi‐organ analysis in the different groups. The sheep confirmed to be a relevant animal model for TMJ disc surgery and regenerative approaches. The PCL and PCL+PEGDA discs presented a higher risk to increase degenerative changes, due to material fragmentation. None of the tested discs regenerate a new autologous disc, however, PGS+PCL was safe, demonstrated rapid resorption, and was capable to prevent condyle degenerative changes.

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Section: Introductionmentioning

confidence: 99%

A randomized controlled preclinical trial on 3 interposal temporomandibular joint disc implants: TEMPOJIMS—Phase 2

Ângelo

Wang

Morouço

et al. 2021

J Tissue Eng Regen Med

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“…To improve the success rate, reposition stability and implant safety, He et al [ 11 ] (2015) applied Chinese-made anchoring nails in modified disc anchorage surgery. As the shape of the anchoring nail does not fit perfectly with the anatomical structure of a condyle, 7.47% of patients experienced postoperative friction in the parotideomasseteric region [ 12 ]. Our group has previously modified the traditional Chinese-made anchoring nail to reduce discomfort and improve stability.…”

Section: Introductionmentioning

confidence: 99%

Improved anchoring nails: design and analysis of resistance ability

Zhou

Chen

et al. 2018

BMC Oral Health

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BackgroundAnchorage is one of the most important treatments for severe temporomandibular joint disorder (TMD). Anchoring nails have shown great success in clinical trials; however, they can break under pressure and are difficult to remove. In this study, we aimed to evaluate an improved anchoring nail and its mechanical stability.MethodsThe experiment consisted of two parts: a tensile test and finite element analysis (FEA). First, traditional and improved anchoring nails were implanted into the condylar cortical bone and their tensile strength was measured using a tension meter. Second, a three-dimensional finite element model of the condyles with implants was established and FEA was performed with forces from three different directions.ResultsThe FEA results showed that the total force of the traditional and improved anchoring nails is 48.2 N and 200 N, respectively. The mean (±s.d.) maximum tensile strength of the traditional anchoring nail with a 3–0 suture was 27.53 ± 5.47 N. For the improved anchoring nail with a 3–0 suture it was 25.89 ± 2.64 N and with a 2–0 suture it was above 50 N. The tensile strengths of the traditional and improved anchoring nails with a 3–0 suture was significantly different (P = 0.033–< 0.05). Furthermore, the difference between the traditional anchoring nail with a 3–0 suture and the improved anchoring nail with a 2–0 suture was also significantly different (P = 0.000–< 0.01).ConclusionThe improved anchoring nail, especially when combined with a 2–0 suture, showed better resistance ability compared with the traditional anchoring nail.

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