Polymer materials for prevention of postoperative adhesion

Li, Jiannan; Feng, Xiangru; Liu, Baichun; Yu, Yingjie; Sun, Leming; Liu, Tongjun; Wang, Yongheng; Ding, Jianxun; Chen, Xuesi

doi:10.1016/j.actbio.2017.08.002

Cited by 135 publications

(104 citation statements)

References 152 publications

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“…Despite these positive characteristics, cell attachment to unmodified CS is problematic . This characteristic has been explored as an advantage in postoperative adhesion prevention membranes . Due to the inherent poor processability of CS, fiber‐forming additives such as PEO are usually introduced .…”

Section: Introductionmentioning

confidence: 99%

Polymer blending or fiber blending: A comparative study using chitosan and poly(ε‐caprolactone) electrospun fibers

Valente

Ferreira

Henriques

et al. 2018

J of Applied Polymer Sci

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Nonwoven membranes of poly(ε‐caprolactone) (PCL) and chitosan (CS) were produced according to the two methods: by blending the polymers in solution followed by electrospinning – polymer blending method – and by simultaneous deposition of fibers electrospun from separate solutions – fiber blending (FB) method. The two production methods were compared by assessing fiber morphology, mass loss, swelling degree, water contact angle, and mechanical properties of the resulting electrospun membranes. Furthermore, the adhesion, proliferation, and morphology of human dermal fibroblasts on the eight types of scaffold produced were evaluated to assess if the blending method used would influence cell–scaffold interaction. Cell adhesion to the different scaffolds lied in the interval 40–60%, with the CS scaffold presenting the lowest value. Interestingly, cell proliferation was the same when comparing polymer blending and FB scaffolds having 3:1 or 1:3 PCL/CS ratios but very different when the ratio was 1:1 – the FB scaffold sustained a proliferation rate double that of the polymer blending scaffold. This work shows that, when blending polymers to improve the properties of a scaffold for tissue engineering or 3D cell culture, their spatial distribution may considerably affect scaffold's properties and should be considered as another parameter requiring optimization. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47191.

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Section: Introductionmentioning

confidence: 99%

Polymer blending or fiber blending: A comparative study using chitosan and poly(ε‐caprolactone) electrospun fibers

Valente

Ferreira

Henriques

et al. 2018

J of Applied Polymer Sci

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“…A large variety of synthetic polymers, such as polylactide (PLA), poly(ethylene glycol) (PEG), polyglycolide (PGA), poly(ε‐caprolactone) (PCL), and poly(vinyl alcohol) (PVA), and natural polymers including hyaluronic acid, cellulose, dextran, chitosan, icodextrin, and xyloglucan have been applied to postoperative antiadhesion applications . Many adhesion barriers are derived from the biocompatible and biodegradable polymers.…”

Section: Introductionmentioning

confidence: 99%

“…Many adhesion barriers are derived from the biocompatible and biodegradable polymers. Since they are supposed to meet several basic requirements, such as excellent biocompatibility and biodegradability, appropriate retention time, good water solubility, outstanding mechanical properties, and minimal side effects to wound healing …”

Section: Introductionmentioning

confidence: 99%

“…7,8 A large variety of synthetic polymers, such as polylactide (PLA), poly(ethylene glycol) (PEG), polyglycolide (PGA), poly(ε-caprolactone) (PCL), and poly(vinyl alcohol) (PVA), and natural polymers including hyaluronic acid, cellulose, dextran, chitosan, icodextrin, and xyloglucan have been applied to postoperative antiadhesion applications. 1,9 Many adhesion barriers are derived from the biocompatible and biodegradable polymers. Since they are supposed to meet several basic requirements, such as excellent biocompatibility and biodegradability, appropriate retention time, good water solubility, outstanding mechanical properties, and minimal side effects to wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…Since they are supposed to meet several basic requirements, such as excellent biocompatibility and biodegradability, appropriate retention time, good water solubility, outstanding mechanical properties, and minimal side effects to wound healing. 1,10 Hyaluronic acid (HA) is a naturally occurring linear polysaccharide comprised glucuronic acid (β-1,3) N-acetyl-D-glucosamine disaccharide units; it is the only nonsulfated glycosaminoglycan (GAG) in the extracellular matrix (ECM) of all higher animals. 11 HA is found in every part of the body and is responsible for carrying out certain vital activities.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyaluronic acid‐poly(vinyl alcohol) composite cryo‐gel for biofunctional material application

Kuchaiyaphum

rifai

Watanabe

et al. 2018

Polymers for Advanced Techs

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Recently, applications of hyaluronic acid (HA) as a biomaterial were investigated. However, the weak structure of HA gel and the effects of using cross‐linker raised concerns during in vivo resolution. In this study, we investigated the method to solve these two problems using physical cross‐linking and compositing with poly(vinyl alcohol) (PVA). Various weight ratios of HA and PVA solutions were mixed, adjustment of pH to 1.8 using HCl then used to fabricate HA‐PVA cryo‐gel by freezing‐thawing. Young's modulus of the prepared gel rose with the increase of both HA and PVA concentrations or either one of them. We estimated that HA and PVA have exhibited these mechanical properties due to forming a double network. HA‐PVA gel showed kinetic friction force of approximately 10 times of PVA gel, while water contact angle and protein adsorption of HA‐PVA gels were remarkably decreased. The properties of the prepared gel suggest that it can be used for postoperative adhesion prevention applications.

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A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

Cui

Chen

et al. 2020

Adv Funct Materials

197

151

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Despite rapid development of adhesive hydrogels, the typical double-sided adhesives fail to adhere to wet tissues and concurrently prevent postoperative tissue adhesion, thus severely limiting their applications in repair of internal tissues. Herein, a negatively charged carboxyl-containing hydrogel is gradiently, electrostatically complexed with a cationic oligosaccharide by a one-sided dipping method to form a novel Janus hydrogel wet adhesive whose two-side faces demonstrate strikingly distinct adhesive and nonadhesive properties. The lightly complexed surface demonstrates instant robust adhesion to various wet biological tissues even under water since the phase separation induced by electrostatic complexation increases the hydrophobicity and water drainage capacity. Intriguingly, the highly complexed surface is non-adhesive due to complete neutralization of carboxyls in the hydrogels. The Janus hydrogel can be used to replace traditional sutures to treat gastric perforation of rabbits. Animal experiment outcomes reveal that one side of the Janus hydrogel is firmly glued to the stomach tissue, and other side facing outward can efficiently prevent the postoperative adhesion. Molecular simulation elucidates the importance for selecting cationic polymer species. It is believed that gradient polyelectrolyte complexation establish a new direction to create Janus adhesives for internal tissue/organ repair and simultaneous prevention of post-operative adhesion.

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Polymer materials for prevention of postoperative adhesion

Cited by 135 publications

References 152 publications

Polymer blending or fiber blending: A comparative study using chitosan and poly(ε‐caprolactone) electrospun fibers

Polymer blending or fiber blending: A comparative study using chitosan and poly(ε‐caprolactone) electrospun fibers

Hyaluronic acid‐poly(vinyl alcohol) composite cryo‐gel for biofunctional material application

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

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