Prevention, Diagnosis, and Management of Chronic Wounds in Older Adults

Hoversten, Katherine P.; Kiemele, Lester J.; Stolp, Anne; Takahashi, Paul Y.; Verdoorn, Brandon P.

doi:10.1016/j.mayocp.2019.10.014

Cited by 43 publications

(29 citation statements)

References 58 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unhealed chronic wounds are characterized by a prolonged inflammatory phase, delayed cellular proliferation, poor re-epithelialization, and impaired angiogenesis [ 3 , 23 ]. Since wound healing is impaired in diabetic patients, previous studies have reported various modalities, however, controversial results concerning wound healing in diabetic patients were be found.…”

Section: Discussionmentioning

confidence: 99%

“…Skin wound healing is a complex multistep process involving the coordination of activities of multiple tissue and cell types [ 1 ]. Diabetic foot ulcers are a significant intricacy of diabetes mellitus and are probably the major component of the diabetic foot [ 2 , 3 ]. Re-epithelialization, a vital cycle in the beginning phase of wound healing, is the consequence of the movement and multiplication of keratinocytes in the epidermal layer of the skin around the injury.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Far-Infrared Therapy Accelerates Diabetic Wound Healing via Recruitment of Tissue Angiogenesis in a Full-Thickness Wound Healing Model in Rats

et al. 2021

View full text Add to dashboard Cite

Far-infrared ray (FIR) therapy has been applied in the tissue regeneration field. Studies have revealed that FIR could enhance wound healing. However, the biological effects of FIR on diabetic wounds remain unclear. Our study aims to investigate whether FIR could accelerate diabetic wound healing and analyze the biomechanisms. A dorsal skin defect (area, 6 × 5 cm2) in a streptozotocin (STZ)-induced diabetes rodent model was designed. Thirty-two male Wistar rats were divided into 4 groups (n = 8 each subgroup). Group 1 consisted of sham, non-diabetic control; group 2, diabetic control without treatment; group 3, diabetic rats received 20 min FIR (FIR-20, 20 min per session, triplicate/weekly for 4 weeks) and group 4, diabetic rats received 40 min FIR (FIR-40, 40 min per session, triplicate in one week for 4 weeks). The wound healing was assessed clinically. Skin blood flow was measured by laser Doppler. The vascular endothelial growth factor (VEGF), 8-hydroxy-2-deoxyguanosine (8-OHdG), eNOS, and Ki-67, were analyzed with immunohistochemical (IHC) staining. Laser Doppler flowmetry analysis of the blood flow of wounding area revealed the blood flow was higher in diabetic rats who received 40 min FIR (FIR-40) as compared to that in FIR-20 group. The wounding area was significantly reduced in the FIR-40 group than in the diabetic control groups. Histological findings of peri-wounding tissue revealed a significant increase in the neo-vessels in the FIR-treated groups as compared to the controls. IHC staining of periwounding biopsy tissue showed significant increases in angiogenesis expressions (VEGF, eNOS, and EGF), cell proliferation (Ki-67), and suppressed inflammatory response and oxygen radicles (CD45, 8-OHdG) expressions in the FIR-treated groups as compared to that in controls. Treatment with the optimal dosage of FIR significantly facilitated diabetic wound healing and associated with suppressed pro-inflammatory response and increased neovascularization and tissue regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Far-Infrared Therapy Accelerates Diabetic Wound Healing via Recruitment of Tissue Angiogenesis in a Full-Thickness Wound Healing Model in Rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The self-healing property of an organism results in wounds healing within three months, depending upon the injury's severity. However, an uncontrolled infection transforms an acute infection into a chronic one that lasts for months or even years [2].…”

Section: Introductionmentioning

confidence: 99%

“…In the United States, for example, millions of patients are suffering from bone or skin imperfections. The treatment sums for these defects are USD 39 billion and USD 75 billion annually, respectively [2]. In addition, prolonged medicinal resources have caused a burden on the healthcare system.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-Based Therapy for Wound Healing

2022

View full text Add to dashboard Cite

Poor wound healing affects millions of people globally, resulting in increased mortality rates and associated expenses. The three major complications associated with wounds are: (i) the lack of an appropriate environment to enable the cell migration, proliferation, and angiogenesis; (ii) the microbial infection; (iii) unstable and protracted inflammation. Unfortunately, existing therapeutic methods have not solved these primary problems completely, and, thus, they have an inadequate medical accomplishment. Over the years, the integration of the remarkable properties of nanomaterials into wound healing has produced significant results. Nanomaterials can stimulate numerous cellular and molecular processes that aid in the wound microenvironment via antimicrobial, anti-inflammatory, and angiogenic effects, possibly changing the milieu from nonhealing to healing. The present article highlights the mechanism and pathophysiology of wound healing. Further, it discusses the current findings concerning the prospects and challenges of nanomaterial usage in the management of chronic wounds.

show abstract

“…Perante a sua fisiopatologia, origina-se a presença do edema, que é o sinal "padrão ouro" das lesões venosas (Hoversten et al, 2020). A partir desse conhecimento e haja vista a complexidade dos mecanismos, a prevenção e tratamento se concretizam principalmente por meio do controle e manejo correto do edema existente.…”

Section: Introductionunclassified

Lesão iatrogênica decorrente do manejo inadequado da bota de unna: relato de experiência

Mota

Nunes

Barbosa

et al. 2022

RSD

View full text Add to dashboard Cite

A terapia com bota de Unna exige do enfermeiro um comprometimento intenso relacionado ao saber técnico e científico, a fim de erradicar as possíveis complicações. Este estudo tem por objetivo relatar a vivência do Programa Cicatriza diante do cuidado à pessoa com úlcera venosa e as consequências iatrogênicas decorrentes do manejo inadequado da bota da Unna. A metodologia aplicada refere-se a um relato de experiência, com abordagem descritiva e qualitativa, desenvolvido por um programa de pesquisa e extensão do curso de graduação em enfermagem da Universidade Federal de São João Del Rei - Campus Centro Oeste, que realiza atendimentos às pessoas com lesões cutâneas no ambulatório universitário de Estomaterapia. Em 2021, a equipe Cicatriza se deparou com o caso de um paciente com insuficiência venosa, apresentando uma lesão iatrogênica caracterizada pela exposição de tendões, no membro inferior direito (MID). A terapia compressiva é considerada a principal alternativa para o tratamento de úlceras venosas, contudo, se não for aplicada corretamente, os malefícios se sobressaem aos benefícios, acarretando um tratamento não eficaz e aumentando as taxas de recidivas, o custo do tratamento, a quantidade de exsudato e consequentemente os riscos de complicações severas. Portanto, diante a vivência do caso evidencia-se que o êxito no tratamento das úlceras venosas é complexo, dinâmico e multifatorial. Cabe ao enfermeiro, realizar a gestão da clínica que perpassa pela indicação de terapias, produtos apropriados, avaliação e orientação profissional e anuência terapêutica.

show abstract

Prevention, Diagnosis, and Management of Chronic Wounds in Older Adults

Cited by 43 publications

References 58 publications

Far-Infrared Therapy Accelerates Diabetic Wound Healing via Recruitment of Tissue Angiogenesis in a Full-Thickness Wound Healing Model in Rats

Far-Infrared Therapy Accelerates Diabetic Wound Healing via Recruitment of Tissue Angiogenesis in a Full-Thickness Wound Healing Model in Rats

Nanomaterial-Based Therapy for Wound Healing

Lesão iatrogênica decorrente do manejo inadequado da bota de unna: relato de experiência

Contact Info

Product

Resources

About