Prevention and treatment of chronic heart failure through traditional Chinese medicine: Role of the gut microbiota

Jia, Qiujin; Wang, Lirong; Zhang, Xiaonan; Ding, Yanfang; Li, Hao; Yang, Yingxi; Zhang, Ao; Li, Yanyang; Lv, Shichao; Zhang, Junping

doi:10.1016/j.phrs.2019.104552

Cited by 67 publications

(47 citation statements)

References 80 publications

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“…e clinical application of traditional Chinese medicine (TCM) has a long history in China. Due to the therapeutic effects and unique ability of TCM in treating health problems that Western medicines cannot solve, TCM has been attracting more and more attention all over the world [1][2][3]. It has been reported that about 4 billion people in the world are using TCM for medical treatment, accounting for 80% of the world's population [4].…”

Section: Introductionmentioning

confidence: 99%

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Han

Guo

Meng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Introduction. Forsythin is the main ingredient of Forsythia suspensa and is widely used in treatment of fever, viral cold, gonorrhea, and ulcers clinically. This study aimed to evaluate the potential genetic toxicity of forsythin and its safety for human use. Methods. Based on the Good Laboratory Practice regulations and test guidelines, the genetic toxicity of forsythin was assessed by the Ames test, chromosome aberration (CA) test, and bone marrow micronucleus (MN) test in vivo. In the Ames test, five strains of Salmonella typhimurium were exposed to different concentrations of forsythin in the presence or absence of the S9 mixture, and then, the number of His + revertant colonies was counted. In the CA test, Chinese hamster lung (CHL) fibroblast cells were treated with different concentrations of forsythin, mitomycin C, or cyclophosphamide in the presence or absence of the S9 mixture, and the chromosomal aberrations were determined. In the MN test, bone marrow was isolated from the mice with different treatments, and the ratios of polychromatic erythrocytes (PCE) and erythrocytes (PCE/(PCE + NCE)) were measured. Finally, beagle dogs were divided into four groups (negative control, low dose, medium dose, and high dose groups), and then, a telemetry system was used to evaluate the safe use of forsythin. Results. Ames test results showed that the number of colonies in all test strains with different treatments showed no significantly dose-dependent increase in the presence or absence of the S9 mixture ( p > 0.05 ). In the CA test, the number of cells with aberrations in the CHL fibroblast cells treated with low, medium, and high doses of forsythin for 24/48 h in the absence of the S9 mixture was, respectively, 5.0/2.5, 4.5/1.5, and 5.0/5.0, and in the presence of the S9 mixture, the number was, respectively, 5.0, 5.0, and 4.5. These results showed that there was no significant difference compared to the negative control group either in the presence (2.0) or in the absence (4.0/2.5 for 24/48 h) of the S9 mixture ( p > 0.05 ). The MN test showed that the values of PCE/(PCE + NCE) in the negative, positive controls, and forsythin treatment groups were all more than 20%, which indicated that forsythin had no cytotoxicity. Additionally, no significant toxicological effects of forsythin on blood pressure, respiration, temperature, electrocardiogram, and other physiological indicators in the conscious beagle dogs of different groups were observed by the telemetry method. Conclusion. Our findings showed that forsythin has low probability of genetic toxicity and no significant toxicological effects, which implied that forsythin is suitable for further development and potential application.

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Section: Introductionmentioning

confidence: 99%

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Han

Guo

Meng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Gut microbiota, a large and complex microbial community in the gastrointestinal tract, is essential to the host’s health and well-being ( Koh et al 2016 ; Liu et al 2020 ). Gut microbiota can not only break down the indigestible carbohydrates in food ( Schwalm and Groisman 2017 ), but also produce short-chain fatty acids (SFAs), which can provide nutrition for gut microbiota ( Jia et al 2020 ). The disturbance of gut microbiota induces inflammation, insulin resistance, diabetes, and osteoporosis ( Ma et al 2019 ; Bi et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Lactobacillus plantarum BW2013 on The Gut Microbiota in Mice Analyzed by 16S rRNA Amplicon Sequencing

Tong

Niu

et al. 2021

Polish Journal of Microbiology

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Lactobacillus plantarum BW2013 was isolated from the fermented Chinese cabbage. This study aimed to test the effect of this strain on the gut microbiota in BALB/c mice by 16S rRNA amplicon sequencing. The mice were randomly allocated to the control group and three treatment groups of L. plantarum BW2013 (a low-dose group of 108 CFU/ml, a medium-dose group of 109 CFU/ml, and a high-dose group of 1010 CFU/ml). The weight of mice was recorded once a week, and the fecal samples were collected for 16S rRNA amplicon sequencing after 28 days of continuous treatment. Compared with the control group, the body weight gain in the treatment groups was not significant. The 16S rRNA amplicon sequencing analysis showed that both the Chao1 and ACE indexes increased slightly in the medium-dose group compared to the control group, but the difference was not significant. Based on PCoA results, there was no significant difference in β diversity between the treatment groups. Compared to the control group, the abundance of Bacteroidetes increased in the low-dose group. The abundance of Firmicutes increased in the medium-dose group. At the genus level, the abundance of Alloprevotella increased in the low-dose group compared to the control group. The increased abundance of Ruminococcaceae and decreased abundance of Candidatus_Saccharimonas was observed in the medium-dose group. Additionally, the abundance of Bacteroides increased, and Alistipes and Candidatus_Saccharimonas decreased in the high-dose group. These results indicated that L. plantarum BW2013 could ameliorate gut microbiota composition, but its effects vary with the dose.

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“…Studies have revealed the link between gut microbiota and heart failure, mainly through intestinal barrier damage and bacterial translocation to induce inflammation and immune response [44]. HM can regulate intestinal microflora, protect the intestinal mucosal barrier, restore the intestinal microbial diversity, and enhance the immune function [45][46][47][48].…”

Section: Gut Microbiota and Herbalmentioning

confidence: 99%

Cross-Talk between Gut Microbiota and the Heart: A New Target for the Herbal Medicine Treatment of Heart Failure?

Zhong

Cheng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Heart failure (HF) is the severe and terminal stage of various heart diseases. A growing number of studies have suggested the potential clinical significance of gut microbiota in the pathophysiology of HF. Herbal medicine (HM) plays a role in rebalancing the composition of gut microbiota and is widely used in the prevention and treatment of HF. There are many similarities between intestinal microecology and the traditional Chinese medicine (TCM) theory, such as the holistic concept and the theory of the “heart’s connection with the small intestine.” These similarities provide a theoretical basis for HM to prevent and treat diseases by regulating the intestinal flora and its metabolites. In this work, the cross-talk between gut microbiota and the heart is reviewed, and the relationship between TCM and gut microbiota is discussed. Based on the current literature and research, we hypothesize that the cross-talk between gut microbiota and the heart may offer a new therapeutic target for HF intervention.

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Prevention and treatment of chronic heart failure through traditional Chinese medicine: Role of the gut microbiota

Cited by 67 publications

References 80 publications

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

The Effect of Lactobacillus plantarum BW2013 on The Gut Microbiota in Mice Analyzed by 16S rRNA Amplicon Sequencing

Cross-Talk between Gut Microbiota and the Heart: A New Target for the Herbal Medicine Treatment of Heart Failure?

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