Prevention and Management of Intrathecal Drug Delivery and Spinal Cord Stimulation System Infections

Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke

“…Other CNS approaches to sustained drug delivery require invasive placement of bioengineered scaffolds or catheters, which will be associated with the damage from the delivery approach. [42][43][44] A translational goal in tissue bioengineering is to track the therapeutic to determine its correct targeting and persistence. MRI with routine imaging sequences was effective in tracking the present hydrogel following injection in both mouse and non-human primate.…”

Spinal cord stimulation for chronic non-cancer pain: a review of current evidence and practice

“…Maintaining a high index of clinical suspicion is important for early diagnosis, and antibiotic treatment should be started without waiting for culture results. 37,38 A positive staining and/or culture of micro-organisms from the surgical wound or implant site confirms the diagnosis. Superficial infections may be successfully managed with antibiotics alone.…”

“…In a review of over 100 cases of infection, 48% were caused by staphylococcus and 3% by pseudomonas. 37 Some risk factors included diabetes, debility, malnutrition, obesity, a very thin body, autoimmune disorders, use of steroids, pre-existing infection, poor hygiene, urinary or faecal incontinence, malabsorption syndrome, and decubitus ulcers. 37 Clinical symptoms and signs of infection include fever, local pain, erythema, swelling, wound secretion, and dehiscence.…”

“…37 Some risk factors included diabetes, debility, malnutrition, obesity, a very thin body, autoimmune disorders, use of steroids, pre-existing infection, poor hygiene, urinary or faecal incontinence, malabsorption syndrome, and decubitus ulcers. 37 Clinical symptoms and signs of infection include fever, local pain, erythema, swelling, wound secretion, and dehiscence. Maintaining a high index of clinical suspicion is important for early diagnosis, and antibiotic treatment should be started without waiting for culture results.…”

Risikoabschätzung in der Schmerztherapie

“…Di ese können leicht sein und nur die Pum pentasche betreffen, es treten aber auch Meningitiden auf. Die totale Infektions rate ist mit unter 5% der implantierten Systeme gering; unter diesen sind 0-14% Meningitisfälle [15]. Einfache Infekti onen lassen sich mit konservativen Maß nahmen -lokale Drainage und Antibio tikagabe -beherrschen; in der Mehrzahl der Fälle (55-80%) muss aber das System explantiert werden.…”