Preventing Zoonotic Influenza Virus Infection

Ramirez, Alejandro; Capuano, Ana W.; Wellman, Debbie A.; Lesher, Kelly A.; Setterquist, Sharon F.; Gray, Gregory C.

doi:10.3201/eid1206.051576

Cited by 68 publications

(61 citation statements)

References 11 publications

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“…Similar serologic studies in humans in the United States showed markedly elevated antibody titers for North American SIVs of subtype H1N1 and H1N2 in SWs compared with controls ( 5 , 8 , 10 , 11 , 32 , 33 ). These studies used hemagglutination inhibition instead of virus neutralization assays and reported ORs for increased serologic responses instead of seroprevalence rates.…”

Section: Discussionsupporting

confidence: 52%

Swine Influenza Virus Antibodies in Humans, Western Europe, 2009

Gerloff

Kremer²,

Charpentier³

et al. 2011

Emerg. Infect. Dis.

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Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses—pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a 2007–08 seasonal subtype H1N1—in 211 persons with swine contact and 224 matched controls in Luxembourg. Persons whose profession involved contact with swine had more neutralizing antibodies against SIV and pandemic (H1N1) 2009 virus than did the controls. Controls also had antibodies against these viruses although exposure to them was unlikely. Antibodies against SIV and pandemic (H1N1) 2009 virus correlated with each other but not with seasonal subtype H1N1 virus. Sequential exposure to variants of seasonal influenza (H1N1) viruses may have increased chances for serologic cross-reactivity with antigenically distinct viruses. Further studies are needed to determine the extent to which serologic responses correlate with infection.

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Section: Discussionsupporting

confidence: 52%

Swine Influenza Virus Antibodies in Humans, Western Europe, 2009

Gerloff

Kremer²,

Charpentier³

et al. 2011

Emerg. Infect. Dis.

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“…These participants also did not use tobacco, a recently identified risk factor among swine facility workers with elevated serum antibodies against swine strains of influenza ( 9 ). …”

Section: Discussionmentioning

confidence: 99%

Avian Influenza among Waterfowl Hunters and Wildlife Professionals

Gill

Webby

Gilchrist

et al. 2006

Emerg. Infect. Dis.

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“…They have included serosurveys of bird cullers, open bird market workers, swine workers, duck hunters, meat processing workers, veterinarians and poultry workers, concluding that these populations are indeed at greater risk of infection with zoonotic influenza virus 5 , 6 , 8 , 9 , 10 , 11 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

“…As per our previous reports, 5 , 6 serum samples were studied for human influenza virus exposure using a hemagglutination inhibition (HI) assay against three recently circulating human influenza virus strains: A/New Caledonia/20/99 (H1N1), A/Nanchang/933/95(H3N2), and A/Panama/2007/99(H3N2). HI titer results were reported as the reciprocal of the highest dilution of serum that inhibited virus‐induced hemagglutination of a 0.65% solution of guinea pig red blood cells.…”

Section: The Studymentioning

confidence: 99%

Avian influenza and poultry workers, Peru, 2006

Ortiz

Kochel

Capuano

et al. 2007

Influenza Resp Viruses

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Background Currently numerous countries in Asia, Africa and Europe are encountering highly pathogenic avian influenza (AI) infections in poultry and humans. In the Americas, home of the world’s largest poultry exporters, contingency plans are being developed and evaluated in preparation for the arrival of these viral strains. Objectives With this cross‐sectional study, to our knowledge the first in its kind in Central or South America, we sought to learn whether Peruvian poultry workers had evidence of previous AI infection and if so, to determine the risk factors for infection. Methods We performed a cross‐sectional seroprevalence study among 149 workers on a Peruvian poultry farm (132 exposed to poultry and 17 non‐exposed controls), serum samples were tested for human influenza virus exposure using a hemagglutination inhibition (HI) assay. Microneutralization assays were performed on all serum samples to detect antibodies against prototypic AI strains H4 through H12. Results Using multivariate proportional odds modeling we found that the prevalence of elevated titers against AI viruses was low in both groups, exposed and non‐exposed controls. Conclusions No evidence of previous AI infection among Peruvian poultry workers was found in this first cross‐sectional study performed in South America. This first occupational study of AI in Latin America was encouraging, but it likely reflects the sector of poultry production with higher biosecurity.

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Preventing Zoonotic Influenza Virus Infection

Cited by 68 publications

References 11 publications

Swine Influenza Virus Antibodies in Humans, Western Europe, 2009

Swine Influenza Virus Antibodies in Humans, Western Europe, 2009

Avian Influenza among Waterfowl Hunters and Wildlife Professionals

Avian influenza and poultry workers, Peru, 2006

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