Preventing microbial colonisation of catheters: Antimicrobial and antibiofilm activities of cellobiose dehydrogenase

Thallinger, Barbara; Argirova, Maya; Lesseva, Magdalena; Ludwig, Roland; Sygmund, Christoph; Schlick, Angelika; Nyanhongo, Gibson S.; Guebitz, Georg M.

doi:10.1016/j.ijantimicag.2014.06.016

Cited by 42 publications

(32 citation statements)

References 29 publications

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“…Another method of CDH immobilization was developed by Thallinger et al [145], who treated the surface of amino-functionalized PDMS with glutaraldehyde and subsequently grafted CDH to the remaining aldehyde groups at the interface. The coating was able to maintain its antimicrobial activity like its previous study [139] even in artificial urine medium.…”

Section: Antimicrobial Urinary Catheter Coating Agents/materials Isupporting

confidence: 53%

“…H 2 O 2 is also used by peroxidases to oxidize halides to more potent antimicrobial agents. Some of the commonly studied oxidative enzymes are glucose oxidase [138], cellobiose dehydrogenase [139, 140], superoxide dismutase, myeloperoxidase, lactoperoxidase [141] and horseradish peroxidase. Quorum quenching enzymes attack acylhomoserine lactone (AHL), the signaling molecule in bacteria without which the bacteria are unable to communicate with each other and hence cannot produce virulence compounds [142].…”

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

“…A group in Austria has been able to both incorporate and immobilize cellobiose dehydrogenase on PDMS through different methods [139, 145, 146]. CDH is produced by a wood degrading fungus and uses cello-oligosaccharides as electron donors to produce H 2 O 2 .…”

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

“…CDH is produced by a wood degrading fungus and uses cello-oligosaccharides as electron donors to produce H 2 O 2 . In 2014, Thallinger et al demonstrated the ability of a CDH/cellobiose system to inhibit several CAUTI pathogens including MRSA by generating H 2 O 2 in the presence of either cellobiose or extracellular polysaccharaides (EPS) [139]. This antimicrobial system was incorporated into the catheter’s lubricant which is an easy, effective, and cost reducing strategy.…”

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

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A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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More than 75% of hospital-acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 15–25% of hospitalized patients. Among other purposes, urinary catheters are primarily used for draining urine after surgeries and for urinary incontinence. During catheter-associated urinary tract infections, bacteria travel up to the bladder and cause infection. A major cause of catheter-associated urinary tract infection is attributed to the use of non-ideal materials in the fabrication of urinary catheters. Such materials allow for the colonization of microorganisms, leading to bacteriuria and infection, depending on the severity of symptoms. The ideal urinary catheter is made out of materials that are biocompatible, antimicrobial, and antifouling. Although an abundance of research has been conducted over the last forty-five years on the subject, the ideal biomaterial, especially for long-term catheterization of more than a month, has yet to be developed. The aim of this review is to highlight the recent advances (over the past 10 years) in developing antimicrobial materials for urinary catheters and to outline future requirements and prospects that guide catheter materials selection and design.

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Section: Antimicrobial Urinary Catheter Coating Agents/materials Isupporting

confidence: 53%

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

Section: Antimicrobial Urinary Catheter Coating Agents/materials Imentioning

confidence: 99%

See 2 more Smart Citations

A review of the recent advances in antimicrobial coatings for urinary catheters

2017

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“…An Austrian group developed versatile methods to immobilize cellobiose dehydrogenase (CDH) on the catheter surface (Fig. ), which produced H 2 O 2 and successfully inhibited all kinds of uropathogens . Haloperoxidases and lactoperoxidase are another type of antibacterial enzymes that catalyze the oxidation of halide, pseudohalide ions to the more potent hypohalous acids, pseudohypohalous acids, and molecular halogens in the presence of H 2 O 2 .…”

Section: Antimicrobial Strategies For Urinary Cathetersmentioning

confidence: 99%

Antimicrobial strategies for urinary catheters

Zhu

Wang

et al. 2018

J Biomedical Materials Res

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Over 75% of hospital‐acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 16% of hospitalized patients. Taking the United States as an example, the costs of catheter‐associated urinary tract infections (CAUTI) are in excess of $451 million dollars/year. The biofilm formation by pathogenic microbes that protects pathogens from host immune defense and antimicrobial agents is the leading cause for CAUTI. Thus, tremendous efforts have been devoted to antimicrobial coating for urinary catheters in the past few decades, and it has been demonstrated to be one of the most direct and efficient strategies to reduce infections. In this article, we briefly summarize the current methods for preparation of antimicrobial coatings based on different stages in the biofilm formation, highlight recent progress in the urinary catheter coating material design and selection, discuss approaches to improving their long‐term antimicrobial efficacy, biocompatibility, multidrug resistance and recurrent infections, and finally outline future requirements and prospects in antimicrobial coating material design. The scope of the works surveyed is confined to antimicrobial urinary catheters. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 445–467, 2019.

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Cellobiose dehydrogenase and chitosan‐based lysozyme responsive materials for antimicrobial wound treatment

Öhlknecht

Tegl

Beer

et al. 2016

Biotech & Bioengineering

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The treatment of wound infection still constitutes a major threat in health care due to the increasing number of bacterial resistances and the difficulty of timely infection detection. Here, we present a smart antimicrobial system that is activated in case of infection based on elevated lysozyme activities. N-acetyl chitosan (degree of N-acetylation: 40%) was synthesized and hydrolysis by lysozyme in artificial wound fluid (AWF) was demonstrated. This resulted in the formation of N-acetylated chito oligosaccharides (COS) with a degree of polymerization of 2-5 units. The COS were shown to serve as substrate for cellobiose dehydrogenase (CDH) leading to the production of 1 mM antimicrobial hydrogen peroxide (H O ) after 24 h incubation at 37°C in AWF. Growth inhibition was seen upon incubation of Escherichia coli and Staphylococcus aureus with this chitosan-CDH system over 8 h. This approach represents the first self-regulating system for the infection responsive inhibition of bacterial growth in response to lysozyme as infection biomarker. Biotechnol. Bioeng. 2017;114: 416-422. © 2016 Wiley Periodicals, Inc.

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Preventing microbial colonisation of catheters: Antimicrobial and antibiofilm activities of cellobiose dehydrogenase

Cited by 42 publications

References 29 publications

A review of the recent advances in antimicrobial coatings for urinary catheters

A review of the recent advances in antimicrobial coatings for urinary catheters

Antimicrobial strategies for urinary catheters

Cellobiose dehydrogenase and chitosan‐based lysozyme responsive materials for antimicrobial wound treatment

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