Preventable risk factors for osteoporosis in postmenopausal women: Systematic review and meta-analysis

Thulkar, Jyoti; Singh, Shalini; Sharma, Shashi; Thulkar, Tanmay

doi:10.4103/0976-7800.191013

Cited by 38 publications

(27 citation statements)

References 21 publications

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“…As expected, the group of postmenopausal women diagnosed with osteoporosis had a significantly higher mean age than the osteopenic or unaltered group, corroborating with results presented by other studies, since the advance in age is inversely associated with BMD (26)(27)(28) . Regarding the anthropometric variables that characterize the sample, it was observed that women with no alteration in BMD presented significantly greater height than osteoporotic women, however, with no differences for body weight or BMI.…”

Section: Discussionsupporting

confidence: 81%

“…Regarding the anthropometric variables that characterize the sample, it was observed that women with no alteration in BMD presented significantly greater height than osteoporotic women, however, with no differences for body weight or BMI. A recent systematic review and meta-analysis involving postmenopausal women confirmed that among these three variables, height is the one that is most strongly associated with the diagnosis of osteoporosis, with no evidence for body weight or BMI, which limits interventions as this variable is not modifiable (26) . Contrary to our initial hypothesis, the isokinetic peak torque of knee extensors and flexors at 60º/s and 180º/s was not significantly different between BMD classifications, nor was there any significant correlation between these variables.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between bone mineral density, isokinetic peak torque and postural balance in postmenopausal women

Oliveira¹,

Oliveira²,

Santos³

et al. 2020

mtprehabjournal

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Background: Postmenopausal women typically present loss of bone mineral density (BMD), muscular strength, and postural balance. However, there is no consensus in the literature on the correlation between these variables. Objectives: Our objective was to verify the correlation between BMD, isokinetic peak torque of knee extensors and flexors, and static postural balance in postmenopausal women. Methods: Fifty-one postmenopausal women underwent BMD evaluation through dual-energy X-ray absorptiometry (DXA) for four bone regions (lumbar spine, femoral neck, total hip, and trochanter). Muscular strength of knee extensors and flexors was evaluated in an isokinetic dynamometer at 60 and 180 degrees per second in the dominant lower limb. Static postural balance was evaluated on a force platform during five different tasks (bipodal eyes open, bipodal eyes closed, semi-tandem eyes open, semi-tandem eyes closed, and unipodal). Statistical analysis involved Spearman's correlation coefficient (rho). Results: There was no significant correlation between BMD and isokinetic peak torque of knee extensors and flexors. Approximately half (27 of 60) of the postural balance variables presented significant inverse correlations (p < 0.05) with BMD and of these, the majority (22 of 27) presented moderate correlation (rho between -0.49 and -0.30). Most correlations were for bipodal support tasks with eyes open and eyes closed. Conclusion: Greater postural oscillation in different balance tasks was correlated with lower BMD in postmenopausal women. Therefore, it is suggested that intervention protocols for women with impaired BMD, especially osteoporotic, consider balance training as part of rehabilitation.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Correlation between bone mineral density, isokinetic peak torque and postural balance in postmenopausal women

Oliveira¹,

Oliveira²,

Santos³

et al. 2020

mtprehabjournal

View full text Add to dashboard Cite

show abstract

“…O steoporosis is a severe condition of low bone mineral density (BMD). Patients with osteoporosis have a high fracture hazard, leading to physical impairment, significant pain and even untimely death (Lloret et al, 2016;Thulkar et al, 2016;Weisz, 2017). Preventive treatments include maintaining or increasing bone mineral density (BMD) when its loss is induced by decreasing levels of sex steroid levels with age in both males and females (Wang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Red wine polyphenols modulate bone loss in the ovariectomized rat model of postmenopausal osteoporosis

Passali

Patsaki

Lelovas

et al. 2019

J Hellenic Vet Med Soc

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The aim of this study was to examine the effect of Red Wine Polyphenols (RWPs) extract on bone mineral density (BMD) in the ovariectomized (OVX) rat model. Thirty-five 10-month-old Wistar rats were separated into controls (CTRL), OVX and OVX plus RWPs in their drinking water (dose, 50 mg/kg body weight per day), starting immediately after OVX for 6 months. Βody and uterine weight, BMD of the tibia at baseline, 3 and 6 months post-OVX, and 3-pointing bending of the femur, were examined. Statistical comparison of the total tibia BMD within groups during the study period showed a significant reduction in the OVX and OVX+RWPs groups both from baseline to 3 and 6 months and from 3 to 6 months, whereas in the CTRL group, there was no significant change. For the proximal tibial metaphysis, comparison of BMD percentage changes from baseline to 3 months and 6 months and from 3 to 6 months revealed highly statistical differences between OVX and OVX+RWPs groups (P = 0.000). OVX induced a significant reduction of biomechanical parameters as expected; the 3-point bending test showed that the maximum force before fracture, energy absorption and fracture stress significantly increased in the OVX group treated with RWPs compared with the nontreated OVX rats (P = 0.048, P = 0.002 and P = 0.003, respectively). Dietary intake of RWPs for 6 months significantly prevented trabecular bone loss and improved bone strength in estrogen-deficient ovariectomized rats.

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“… 4 However, the rate of osteoporosis is far higher in Asian population, and it has been estimated that about 50% of the people will be victims of osteoporosis by 2050. 10 Furthermore, this problem is more centered in populations residing in the rural areas, and a majority of population in Nepal live in such communities where people with osteoporosis remain undiagnosed. Specially in our country, 50% of the total population are women, and among them greater than 50% are elderly, 11 and this is the group that is at high risk for osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Pardhe¹,

Pathak²,

Bhetwal³

et al. 2017

IJWH

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BackgroundOsteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women.MethodsA descriptive cross-sectional study was conducted over a period of 6 months among the female population of Dholahity community, Lalitpur, Nepal. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated as per the guideline provided by the reagent manufacturer, and hormonal assay, particularly estradiol level assessment, was performed by chemiluminescence immunoassay-based technique.ResultsA significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women, whereas a significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal (p<0.001). Age was significantly correlated with bone markers (ALP and calcium) in postmenopausal group (p<0.005), while there was no significant correlation in premenopausal group. In addition, there was significant positive correlation between calcium and estradiol in postmenopausal women, while ALP was negatively correlated with estradiol in that group. Further, no significant correlation was demonstrated between estradiol and bone markers in postmenopausal women in body mass index and age-adjusted partial correlation analysis.ConclusionTimely diagnosis of osteoporosis in women would be of significant benefit for effective care for required populations and help to minimize mortality rate and financial burden of our country.

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Preventable risk factors for osteoporosis in postmenopausal women: Systematic review and meta-analysis

Cited by 38 publications

References 21 publications

Correlation between bone mineral density, isokinetic peak torque and postural balance in postmenopausal women

Correlation between bone mineral density, isokinetic peak torque and postural balance in postmenopausal women

Red wine polyphenols modulate bone loss in the ovariectomized rat model of postmenopausal osteoporosis

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

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