Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Pardhe, Bashu Dev; Pathak, Sabala; Bhetwal, Anjeela; Ghimire, Sumitra; Shakya, Shreena; Khanal, Puspa Raj; Marahatta, Sujan Babu

doi:10.2147/ijwh.s145191

Cited by 38 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study also, there is no significant correlation observed. 2,3,6,7 In our study also there is a significant correlation found with a P-value of 0.019. This difference may be due to the changes in dietary intake of phosphorus and ethinicity.…”

Section: Discussionsupporting

confidence: 75%

“…6,7 Bone formation outpaces resorption until peak bone mass is reached at around 30 years of age. 2 Once the women is in her fourth decade, there is a gradual loss of bone mineral density. 8 According to literature it was found that from the first year after menopause there is a progressive fall in bone density values up to 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…In the study by Pardhe BD et al there was a significant correlation found between BMI and serum phosphorus levels where as no significant correlation was observed in the present study. 2 In obesity, the activity of ALP is enhanced and ALP is released from adipose tissue into blood circulation in excessive amounts disproportionate to the intracellular fat depots. 11 In the previous studies there was no significant correlation found between BMI and serum ALP levels.…”

Section: Discussionmentioning

confidence: 99%

“…1 The rate of osteoporosis is higher in Asian population , and it has been estimated that about 50% of people will be victims of osteoporosis by 2050. 2 With the onset of menopause, there is rapid bone loss, believed to be approximately 2%-3% over the following 5-10 years, and this is greatest in the early postmenopausal years. 3 A preventive strategy should ideally be initiated before the occurrence of fractures.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Correlation of biomarkers and bone mineral density for osteoporosis in post-menopausal women

Hymavathi

Jakka

Paturi

2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Osteoporosis is a metabolic bone disorder characterised by a low bone mass and microarchitectural deterioration of bone tissue followed by enhanced bone fragility and a consequent rise in fracture risk. Aim of the study is to correlate the biomarkers and bone mineral density in postmenopausal osteoporosis.Methods: This is a prospective study done in the department of obstetrics and gynaecology, Narayana medical College and Hospital, Nellore for a period of 2 years (October 2016-October 2018). This study was designed to assess the correlation between bone mineral density (BMD) and various biochemical markers.Results: The mean age of the present study is 60.51±9.35 years. There is a significant correlation found between age, serum phosphorus, urinary OHPr and bone mineral density. The mean BMI of the present study is 24.75±4.25 kg/m2. There is a significant correlation observed between BMI, serum ionized calcium, urinary OHPr and bone mineral density. There exists a significant correlation between BMD and urinary OHPr. It is found that in menopausal women spine and hip are the major sites affected by osteoporosis. The early changes are found in lumbar spine compared to hip. In the present study with increase in BMI there is increase in BMD signifying obesity is a protective factor for osteoporosis leaving aside all it’s ill effects. Urinary hydroxyproline a marker of resorption is found to have a negative correlation with BMD.Conclusions: BMD measurements using DEXA are not readily available in India. Biochemical markers of bone remodelling are useful tools in assessment of osteoporosis and are safe, inexpensive, easily performed. In the present study an attempt is made to correlate biochemical markers and BMD so as to detect osteoporosis even before the changes being evident on imaging studies.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Correlation of biomarkers and bone mineral density for osteoporosis in post-menopausal women

Hymavathi

Jakka

Paturi

2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…We next asked whether there is an age-dependent effect of estrogen on callus BMD as measured by pQCT because of the reduced sensitivity to estrogen with age [22]. Figure 4 summarizes the data from CALCBD ( g. 4a1 and 4b1) and the CORTBD analyses ( g. 4a2 and 4b2) of the healthy ( g. 4a1 and a2) and fractured ( g. 4b1 and b2) arm of postmenopausal women of different ages.…”

Section: Calculated Bone Density and Cortical Bone Density In Estrogementioning

confidence: 99%

Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women

Jäckle

Kolb

Schilling

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopausal women due to their decreased levels of estrogen. Preclinical studies with animals demonstrated that loss of estrogen had a negative effect on bone healing and that increasing the estrogen level led to a better bone healing. We asked whether increasing the estrogen level in menopausal patients has a beneficial effect on bone mineral density (BMD) during callus formation after a bone fracture. Methods: To investigate whether estrogen has a beneficial effect on callus BMD of postmenopausal patients, we performed a prospective double-blinded randomized study with 76 patients suffering from distal radius fractures. A total of 31 patients (71.13 years ± 11.99) were treated with estrogen and 45 patients (75.62 years ± 10.47) served as untreated controls. Calculated bone density as well as cortical bone density were determined by peripheral quantitative computed tomography (pQCT) prior to and six weeks after the surgery. Comparative measurements were performed at the fractured site and at the corresponding position of the non-fractured arm. Results: We found that unlike with preclinical models, bone fracture healing of human patients was not improved in response to estrogen treatment. Furthermore, we observed no dependence between age-dependent bone tissue loss and constant callus formation in the patients . Conclusions: Transdermally applied estrogen to postmenopausal women, which results in estrogen levels similar to the systemic level of premenopausal women, has no significant beneficial effect on callus BMD as measured by pQCT, as recently shown in preclinical animal models.

show abstract

Gender-Affirming Hormone Treatment Decreases Bone Turnover in Transwomen and Older Transmen

Vlot

Wiepjes

Jongh

et al. 2019

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Sex steroids play a key role in bone turnover and preserving BMD; hence, gender-affirming hormone treatment (HT) in transgender people affects bone metabolism. Most studies have looked into the effect of HT on changes in BMD; however, they do not provide insights into changes in bone metabolism caused by HT. This study investigated changes in bone turnover markers (BTMs) and sclerostin, as well as their correlations with change in BMD in transwomen and transmen during the first year of HT. Transwomen received estradiol and antiandrogens; transmen received testosterone. Sclerostin; P1NP; alkaline phosphatase (ALP); CTx; and BMD of the total hip, the femoral neck, and the lumbar spine were evaluated at baseline and after 1 year of HT. There were 121 transwomen (median age 30 years, interquartile range [IQR] 24 to 41 years) and 132 transmen (median age 24 years, IQR 21 to 33 years) included in the study. In transwomen, ALP decreased in 19% (95% CI, -21 to-16), CTx in 11% (95% CI, -18 to-4), and sclerostin in 8% (95%CI, -13 to-4) of study participants after 1 year of HT. In contrast, in transmen P1NP, ALP, and sclerostin increased in 33% (95% CI, 24 to 42), 16% (95% CI, 12 to 20), and 15% (95% CI, 10 to 20) of study participants, respectively, after 1 year of HT. No age differences were seen in transwomen, whereas in transmen aged ≥50 years a decrease in all BTMs was found in contrast with the other age groups. These transmen had low estrogen concentration at the start of HT based on their postmenopausal state before the start of HT; their estradiol concentrations increased during testosterone treatment. Changes in BTMs and BMD were weakly correlated (correlation coefficient all <0.30). To conclude, 1 year of HT resulted in decreased bone turnover in transwomen and older transmen, whereas it increased in younger transmen. The decrease in bone resorption in older transmen shows the importance of estrogen as a key regulator of bone turnover.■ 1864 VLOT ET AL. HT = gender-affirming hormonal treatment; IQR = interquartile range; LH = luteinizing hormone; AST = aspartate transaminase; ALT = alanine transaminase; γGT = gamma-glutamyltransferase. Journal of Bone and Mineral Research■ 1866 VLOT ET AL.

show abstract

Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Cited by 38 publications

References 21 publications

Correlation of biomarkers and bone mineral density for osteoporosis in post-menopausal women

Correlation of biomarkers and bone mineral density for osteoporosis in post-menopausal women

Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women

Gender-Affirming Hormone Treatment Decreases Bone Turnover in Transwomen and Older Transmen

Contact Info

Product

Resources

About