Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas. Actualización 2012. Documento de consenso SEIMC/SEGO/SEN/SEQ/SEMFYC

Alós, Juan-Ignacio; Domingo, Antonia Andreu; Mir, Lorenzo Arribas; Cabero, L.; Cueto-López, Marina de; Sastre, Jose Lopez; Marcos, Juan Carlos; Prieto, Alberto Puertas; Fraile, Manuel de la Rosa; Abizanda, Salvador Salcedo; Luna, Manuel Sánchez; Pérez, María José Sánchez; Cardoso, Rafael Torrejón

doi:10.1016/j.eimc.2012.03.013

Cited by 30 publications

(13 citation statements)

References 109 publications

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“…Some studies have performed the screening of circulating GBS isolates in pregnant women using vaginal and rectal samples and they have reported a reduction of susceptibility to penicillin, > 50% of resistance to macrolide and clindamycin 5 , 23.0% of resistance to erythromycin, and 1.3% of resistance to levofloxacin 4 .…”

Section: Introductionmentioning

confidence: 99%

ANTIMICROBIAL SUSCEPTIBILITY OF Streptococcus agalactiae ISOLATED FROM PREGNANT WOMEN

Melo

Santos

Oliveira

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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SUMMARYIntroduction:Group B streptococcus (GBS) or Streptococcus agalactiae can colonize the gastrointestinal and genitourinary tracts and has been considered one of the most important risk factors for the development of neonatal disease. The present study evaluated the antimicrobial susceptibility of GBS isolates from pregnant women who were attended at a public health service in Northern Paraná, Brazil. Methods:A descriptive analytical cross-sectional study was performed with 544 pregnant women, at ≥ 35 weeks of gestation. One hundred and thirty-six GBS isolates from pregnant women were tested for antimicrobial susceptibility. Results:All of the GBS isolates showed susceptibility to the drug that is most frequently used for intrapartum prophylaxis: penicillin. Resistance to clindamycin and erythromycin was detected, thus decreasing the options of prophylaxis in women who are allergic to penicillin. Conclusions: Additional studies should be conducted to increase the knowledge of GBS sensitivity profile to antimicrobials in other health centers.

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Section: Introductionmentioning

confidence: 99%

ANTIMICROBIAL SUSCEPTIBILITY OF Streptococcus agalactiae ISOLATED FROM PREGNANT WOMEN

Melo

Santos

Oliveira

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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“…Esto ha dado lugar a la recomendación de realizar un cribado antenatal para detectar la presencia de colonización por EGB en las gestantes entre las semanas 35-37 y, en el caso de estar colonizadas, utilizar la profilaxis antibiótica intraparto (PAI) para evitar la transmisión madre-hijo 3,4 , lo que ha revertido en una disminución drástica de los casos de infección neonatal precoz por EGB 1,2,5,6 . Los antibióticos recomendados para tal fin actualmente son penicilina/ampicilina, y en caso de pacientes alérgicas, clindamicina, cefazolina y vancomicina 3,4 . EGB sigue siendo universalmente sensible a la penicilina, aunque se han comunicado casos de cepas con sensibilidad disminuida 7 .…”

Section: Introductionunclassified

Serotipos y patrones de resistencia antibiótica en aislados betahemolíticos de Streptococcus agalactiae de madres colonizadas y recién nacidos con enfermedad invasiva

Liébana-Martos¹,

Cabrera-Alavargonzalez²,

Rodríguez‐Grangér³

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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“…Evidence-based recommendations have been insufficient to date, and neonatal management remains challenging. Guidelines often recommend administering empirical antibiotics to well-appearing neonates at risk of EOS (WAARNs)[12-14]. Algorithms are usually based on the assumption that the presence of maternal risk factors (RFs) implies a higher neonatal risk of EOS.…”

Section: Introductionmentioning

confidence: 99%

Serial physical examinations, a simple and reliable tool for managing neonates at risk for early-onset sepsis

Berardi¹,

Buffagni²,

Rossi³

et al. 2016

WJCP

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AIMTo investigate whether serial physical examinations (SPEs) are a safe tool for managing neonates at risk for early-onset sepsis (EOS).METHODSThis is a retrospective cohort study of neonates (≥ 34 wks’ gestation) delivered in three high-volume level IIIbirthing centres in Emilia-Romagna (Italy) during a 4-mo period (from September 1 to December 31, 2015). Neonates at risk for EOS were managed according to the SPEs strategy, these were carried out in turn by bedside nursing staff and physicians. A standardized form detailing general wellbeing, skin colour and vital signs was filled in and signed at standard intervals (at age 3, 6, 12, 18, 36 and 48 h) in neonates at risk for EOS. Three independent reviewers reviewed all charts of neonates and abstracted data (gestational age, mode of delivery, group B streptococcus status, risk factors for EOS, duration of intrapartum antibiotic prophylaxis, postpartum evaluations, therapies and outcome). Rates of sepsis workups, empirical antibiotics and outcome of neonates at-risk (or not) for EOS were evaluated.RESULTSThere were 2092 live births and 1 culture-proven EOS (Haemophilus i) (incidence rates of 0.48/1000 live births). Most newborns with signs of illness (51 out of 101, that is 50.5%), and most of those who received postpartum antibiotics (17 out of 29, that is 58.6%) were not at risk for EOS. Compared to neonates at risk, neonates not at risk for EOS were less likely to have signs of illness (51 out of 1442 vs 40 out of 650, P = 0.009) or have a sepsis workup (25 out of 1442 vs 28 out of 650, P < 0.001). However, they were not less likely to receive empirical antibiotics (17 out of 1442 vs 12 out of 650, P = 0.3). Thirty-two neonates were exposed to intrapartum fever or chorioamnionitis: 62.5% (n = 20) had a sepsis workup and 21.9% (n = 7) were given empirical antibiotics. Among 216 neonates managed through the SPEs strategy, only 5.6% (n = 12) had subsequently a sepsis workup and only 1.9% (n = 4) were given empirical antibiotics. All neonates managed through SPEs had a normal outcome. Among 2092 neonates, only 1.6% (n = 34) received antibiotics; 1.4% (n = 29) were ill and 0.2% (n = 5) were asymptomatic (they were treated because of risk factors for EOS).CONCLUSIONThe SPEs strategy reduces unnecessary laboratory evaluations and antibiotics, and apparently does not worsen the outcome of neonates at-risk or neonates with mild, equivocal, transient symptoms.

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Prevención de la infección perinatal por estreptococo del grupo B. Recomendaciones españolas. Actualización 2012. Documento de consenso SEIMC/SEGO/SEN/SEQ/SEMFYC

Cited by 30 publications

References 109 publications

ANTIMICROBIAL SUSCEPTIBILITY OF Streptococcus agalactiae ISOLATED FROM PREGNANT WOMEN

ANTIMICROBIAL SUSCEPTIBILITY OF Streptococcus agalactiae ISOLATED FROM PREGNANT WOMEN

Serotipos y patrones de resistencia antibiótica en aislados betahemolíticos de Streptococcus agalactiae de madres colonizadas y recién nacidos con enfermedad invasiva

Serial physical examinations, a simple and reliable tool for managing neonates at risk for early-onset sepsis

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