Prevalência e fatores associados à hepatite C em pacientes de hemodiálise

Medeiros, Maria Teresa Gonçalves de; Lima, João L. M. P. de; Lima, José Wellington de Oliveira; Campos, Henry de Holanda; Medeiros, Marta Maria das Chagas; Filho, João Macêdo Coelho

doi:10.1590/s0034-89102004000200006

Cited by 24 publications

(26 citation statements)

References 18 publications

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“…This can occur either through sharing of machines, environmental aerosols, droplets contaminated with the virus or during emergency situations when protective gloves are not replaces by technical teams. [2][3][4][5] Both the sharing of hemodialysis machines of nursing teams has been associated to high incidence of HCV infection. Contamination, in such cases, may be related to the methodology used in the dialysis process, such as through technical errors in biosecurity.…”

Section: Discussionmentioning

confidence: 99%

“…Contamination, in such cases, may be related to the methodology used in the dialysis process, such as through technical errors in biosecurity. [2][3][4][5] The patient may also be in an immunological window whilst sharing a room, machine or nursing team with negative patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] In conclusion, results suggest that transmissibility of HCV in dialysis centers does not occur exclusively through transfusion of contaminated blood. 4 Other factors predominate, such as longer duration of dialysis and the non-segregation of seropositive patients, which are questions of biosecurity. 5 To promote more efficient biosecurity controls, quality programs must be implanted in dialysis centers addressing methodology training of technical teams and constant monitoring by epidemiological authorities.…”

Section: Discussionmentioning

confidence: 99%

“…1,[3][4][5] Anti-HCV exams are administered monthly in dialysis centers, as mandated by regulation n. 82/00 of the Brazilian Ministry of Health (MS). Detection of anti-HCV is undertaken through simple serology tests.…”

Section: Introductionmentioning

confidence: 99%

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Prevalência da soropositividade do anti-HCV em pacientes dialisados

et al. 2006

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This cross-sectional study evaluated the prevalence of anti-hepatitis antibodies and associated factors in dialysis patients. Data were collected from records of all patients receiving dialysis treatment [n=1,261] in the city of Porto Alegre, in Southern Brazil, from August to December 2003. The statistical analyses used were Chi-square and the linear tendency test. Prevalence ratios were also calculated. Multiple logistic regression analysis was performed through Cox regression. The prevalence of antihepatitis antibodies was of 29.1%, and was higher among patients treated by hemodialysis where there was no segregation of seropositive and seronegative patients and where dialyzers were reused. This association remained even when controlling for confounding factors. Patients who received blood transfusions had a linear increase in the prevalence of anti-hepatitis antibodies. The duration of dialysis treatment showed a dose-response curve with the prevalence of anti-hepatitis antibodies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalência da soropositividade do anti-HCV em pacientes dialisados

et al. 2006

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Prevalence of hepatitis C virus infection and genotypes in patient with chronic kidney disease undergoing hemodialysis

et al. 2013

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The prevalence of antibodies to HCV varies among Brazilian regions at rates of 8-16%. Since this virus is transmitted by the parenteral route through blood and blood products, patients receiving maintenance hemodialysis therapy are at an increased risk of infection. The study was conducted in seven dialysis centers in Belém, Pará, northern Brazil. Blood samples were collected from 798 patients with chronic renal disease treated by hemodialysis. The samples were tested for antibodies against HCV and the viral genotype was identified. Sixty-seven (8.4%) of the 798 patients studied were anti-HCV positive by ELISA, ranging from 4% to 14% in different centers. Viral RNA was detected in 5.3% (43/798) of the patients; of these, 42 also had anti-HCV antibodies. HCV genotyping revealed genotype 1 as the most common, detected in 86.1% (37/43) of the patients, followed by genotype 2 in 11.6% (5/43) and genotype 3 in one patient (2.3%). The findings of this study highlight the importance of control strategies for hepatitis C in hemodialysis patients. Molecular biology methods need to be available in these centers to screen for HCV on admission in order to establish effective infection control measures.

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