Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer

Abstract

Peritoneal metastasis from breast cancer is a serious and deadly condition only limited considered in the literature. Our aim was to study prevalence, risk factors, and prognosis of breast cancer peritoneal metastasis. We retrospectively analyzed 3096 women with a diagnosis of invasive breast cancer. We took into consideration presence and localization of breast cancer distant metastasis as well as the possible risk factors and survival from the diagnosis of the breast cancer metastasis. The prevalence of breast cancer peritoneal metastases was 0.7 % (22/3096), representing the 7.6 % (22/289) of women affected by distant metastases. Moreover, independent risk factors for breast cancer peritoneal metastases resulted high grading, lobular invasive histology, and advanced T and N stage at diagnosis. Overall survival after metastasis diagnosis was shorter in women affected by peritoneal metastases or brain metastases in comparison to other metastatic women. Breast cancer peritoneal metastases were uncommon but not rare events with a poor prognosis after standard treatments.

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastasis from Breast Cancer: A Preliminary Report on 4 Cases

“…Typical metastasis sites of BC were bones, lungs, liver and brain. Many other sites had been described in the literature, including the peritoneal metastases [13], with 0.7% of the prevalence of peritoneal metastases [14]. The data about peritoneal and gastrointestinal metastases of BC was the lack in the literature.…”

Breast cancer with intraabdominal metastases. Is surgery necessary?

“…Unfortunately, metastatic breast cancer (MBC) remains a life-threatening condition with no appropriate therapeutic solutions. During their lifetime, 20 to 40% of BC patients will develop metastatic disease [2,6]. Up to 10% of stage IV breast cancers prove to be primary metastaticmetastases being diagnosed simultaneously with primary breast tumor [2].…”

“…During their lifetime, 20 to 40% of BC patients will develop metastatic disease [2,6]. Up to 10% of stage IV breast cancers prove to be primary metastaticmetastases being diagnosed simultaneously with primary breast tumor [2]. The dissemination of metastases is frequently multiorganic.…”

“…Preferred dissemination sites include bones (67%), lungs (31%), liver (35%), brain (11%), skin (7.5%) and other sites (peritoneum (7.6%), ovary (1.5%), etc.) [1,2].…”

“…Apparently, metastases do not always occur in locally advanced breast cancer. Another explanation may be the fact that MBC affects younger patients that are not included in breast cancer screening programs [2].…”