Prevalence, Risk Factors, and Outcomes of Hospitalized Patients With Coronavirus Disease 2019 Presenting as Acute Pancreatitis

Coronavirus Disease (COVID-19) Caused by (SARS-CoV-2) Infections: A Real Challenge for Human Gut Microbiota

“…It was also observed that GIB caused acute hemoglobin decrease that required urgent transfusion for all three patients in order to be stabilized (Gadiparthi et al, 2020). Among the common GI symptoms observed in patients diagnosed with COVID-19, acute pancreatitis was reported in some patients from a clinical study of Inamdar et al where patients manifested upper abdominal pain (Inamdar et al, 2020). SARS-CoV-2 survives successfully in the gut of asymptomatic persons.…”

COVID-19 and acute pancreatitis: examining the causality

“…If COVID-19 is associated with acute pancreatitis, an increase in otherwise idiopathic acute pancreatitis incidence is expected in patients with COVID-19. According to a retrospective cohort study analysing 11,883 hospitalized patients with COVID-19 from 12 hospitals in the USA, there were 32 cases of acute pancreatitis, yielding a point prevalence of 0.27%, 69% of them idiopathic 8 . A retrospective study involving more than 63,000 patients with COVID-19 from 50 Spanish emergency rooms before hospitalization reported a frequency of acute pancreatitis of 0.07% 9 ; although the aetiology was not analysed in this study, COVID-19 was associated with a reduced risk of acute pancreatitis.…”

“…Cases of otherwise idiopathic acute pancreatitis in patients with COVID-19 were first published in China, and then throughout the world 4,8 . There have been case reports and retrospective cohort studies, but the populations under study, definitions of acute pancreatitis 10 and results are heterogeneous, making it difficult to form firm conclusions.…”

“…Retrospective cohort studies 8 and case-control studies have detected a higher proportion of idiopathic acute pancreatitis among patients with COVID-19. The preliminary results of an international multicentre retrospective and prospective case-control study, COVIDPAN (PSGBI webinar), which compared 149 patients with acute pancreatitis and COVID-19 and 1,628 patients with COVID-19-negative acute pancreatitis, showed a rate of idiopathic acute pancreatitis of 24% versus 14% respectively (P = 0.001) (M. Nayar and S. Pandanaboyana; unpublished data).…”

SARS-CoV-2 Virus Manifestations in the Gastrointestinal Tract: Therapeutic Implications

“…Even though the ACE2 receptor and TMPRSS2 are expressed on pancreatic ductular cells, the pancreas itself is rarely affected by COVID-19 [ 14 ]. Inamdar et al [ 54 ] performed a retrospective study and found that only 0.27% of patients presenting with COVID-19 had an acute pancreatitis. The opposite seems more likely: patients with severe COVID-19 develop an acute pancreatitis.…”