Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa

Miller, Iben Marie; McAndrew, Rachel; Hamzavi, Iltefat

doi:10.1016/j.det.2015.08.002

Cited by 131 publications

(182 citation statements)

References 95 publications

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“…30 The age of onset ranges from the second to the fifth decade, with a mean in the early 20s. 18 However, HS has also been reported in children and after menopause. 18,31,32 In fact, 2% of cases occur before the age of 11.…”

Section: Psychosocial Impactmentioning

confidence: 99%

“…18 However, HS has also been reported in children and after menopause. 18,31,32 In fact, 2% of cases occur before the age of 11.…”

Section: Psychosocial Impactmentioning

confidence: 99%

“…24 Prevalence is a matter of debate, with estimated rates as low as 0.00033% up to 4%. 18 A recent USA population-based study found an overall annual incidence of 6 per 100 000. 25 However, in Europe two studies reported a much higher prevalence of 1% 26,27 and Jemec et al 28 even found a prevalence of 4% in a young adult female population in Denmark.…”

Section: Psychosocial Impactmentioning

confidence: 99%

“…1,19,20 An additional contributor to impaired QoL is sexual dysfunction, particularly because of the influence of HS on intimate relationships and sexual activity. 18,21 6. EPIDEMIOLOGY HS is an under recognized entity with a significant delay from the onset of symptoms to the diagnosis, 22,23 with a median delay of 12 years in one study.…”

Section: Psychosocial Impactmentioning

confidence: 99%

“…1 HS has a far-reaching effect on all areas of life and QoL has been found to be more significantly impaired in HS than in diseases like psoriasis, neoplasms, strokes or even heart transplant candidates. 17,18 Furthermore, problems in the familial and social environment, suicidal ideas, fear of stigmatization, and economic difficulties, contribute to the substantial burden of disease.…”

Section: Psychosocial Impactmentioning

confidence: 99%

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Update on Hidradenitis Suppurativa (Part I): Epidemiology, Pathogenesis, Severity assessment and Comorbidities

Silva

Azevedo

Lisboa

2018

SPDV

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Hidradenitis suppurativa (HS) is as a chronic, inflammatory and recurrent skin disease of the hair follicle. Prevalence of HS is a matter of debate, with estimate rates as low as 0.00033% and as high as 4.1%. HS prevalence appears significantly higher in women and has a mean age of onset in the early 20s. The primary histopathologic event seems to be a follicular hyperkeratosis with plugging, dilatation and rupture of the hair follicle resulting with subsequent inflammation and formation of abscesses and sinus tracts. The cause of this is likely multifactorial, involving genetic factors, cigarette smoking, mechanical stress, obesity, immune aberrant response and hormonal abnormalities. HS, as a chronic inflammatory dermatosis, is associated with a variety of concomitant and secondary diseases such as metabolic syndrome, inflammatory and rheumatologic diseases, depression and malignancy, and, for this reason HS management often requires a multidisciplinary team.

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Section: Psychosocial Impactmentioning

confidence: 99%

“…18 However, HS has also been reported in children and after menopause. 18,31,32 In fact, 2% of cases occur before the age of 11.…”

Section: Psychosocial Impactmentioning

confidence: 99%

Section: Psychosocial Impactmentioning

confidence: 99%

Section: Psychosocial Impactmentioning

confidence: 99%

Section: Psychosocial Impactmentioning

confidence: 99%

See 3 more Smart Citations

Update on Hidradenitis Suppurativa (Part I): Epidemiology, Pathogenesis, Severity assessment and Comorbidities

Silva

Azevedo

Lisboa

2018

SPDV

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Hidradenitis Suppurativa

Saunte

Jemec

2017

JAMA

353

200

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Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease

2019

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IMPORTANCE Hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD) are inflammatory diseases that share common genetic susceptibility and immunologic features. However, the link between HS and IBD has been largely unclear. OBJECTIVE To conduct a meta-analysis to investigate the association between HS and IBD. DATA SOURCES A search of the MEDLINE, Cochrane Central Register of Controlled Trials, and Embase databases yielded 397 relevant studies from inception to June 10, 2018. Two additional studies were supplied by one of the investigators. STUDY SELECTION Case-control, cross-sectional, or cohort studies that examined the odds or risk of IBD in patients with HS were included. No geographic or language limitations were imposed. DATA EXTRACTION AND SYNTHESIS The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The Newcastle-Ottawa Scale was used to assess the risk of bias of included studies. Crohn disease and ulcerative colitis were analyzed separately, and a random-effects model meta-analysis was conducted. MAIN OUTCOMES AND MEASURES The odds ratios (ORs) and hazard ratios (HRs) of IBD, Crohn disease, and ulcerative colitis in association with HS. RESULTS Five case-control studies, 2 cross-sectional studies, and 1 cohort study with a total of 93 601 unique participants were included. The meta-analysis of case-control and cross-sectional studies showed significant associations of HS with Crohn disease (pooled OR, 2.12; 95% CI, 1.46-3.08) and ulcerative colitis (pooled OR, 1.51; 95% CI, 1.25-1.82). Two case-control studies found significant association of HS with IBD (ORs, 2.16 [95% CI, 1.40-3.34] and 10.00 [95% CI, 1.94-51.50]). One cohort study found an increased risk of IBD in patients with HS (HR, 5.6; 95% CI not reported; P < .002). CONCLUSIONS AND RELEVANCE The evidence to date supports an association of HS with IBD. These results suggest that consultation with gastroenterologists should be sought when patients with HS present with recurrent abdominal pain, chronic diarrhea, bloody stool, and body weight loss.

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Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa

Cited by 131 publications

References 95 publications

Update on Hidradenitis Suppurativa (Part I): Epidemiology, Pathogenesis, Severity assessment and Comorbidities

Update on Hidradenitis Suppurativa (Part I): Epidemiology, Pathogenesis, Severity assessment and Comorbidities

Hidradenitis Suppurativa

Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease

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