Prevalence Rate of Vulvovaginal Candidiasis and Identification of Candida Species in Women in Referred to Hamedan Hospitals 2013 - 2014, West of Iran

Habibipour, Reza

doi:10.17795/zjrms-6250

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…In the present study, a different frequency of VVC (39.76%) was reported when compared to our previous studies in Ahvaz in 2016 (28.3%) and 2010 (49%) (15,21). The frequency of VVC in other cities in Iran was reported as 62.1%, 43.3%, 40%, 26%, and 4.8% from Ilam, Babol, Arak, Hamadan, and Zanjan, respectively (12,13,16,31,32).…”

Section: Discussionmentioning

confidence: 98%

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Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Kiasat

Rezaei‐Matehkolaei

Mahmoudabadi

et al. 2019

Jundishapur J Microbiol

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Background: Candida vaginitis or vulvovaginal candidiasis (VVC) is the most common mucosal infection of the female genital tract caused by different species of Candida. Despite several antifungal therapies and personal hygiene practices, VVC has remained an important public health problem affecting millions of women worldwide. Objectives: The aim of this study was to determine the prevalence of VVC and the frequency of causative agents in women of different age groups referring to the midwifery clinics in Ahvaz, Iran, from January 2017 to March 2018. Methods: Samples were obtained from 493 women aged 15-64 years with signs and symptoms of VVC using endocervical swabs. All collected samples were cultured on CHROMagar Candida plates and incubated at 35°C for 24-72 h. Various Candida sp. were initially identified using morphologic characteristics and physiologic features, and finally confirmed with PCR-RFLP. Results: Totally 196 (39.76%) cases were diagnosed as VVC, of which nine (4.6%) were as recurrent vulvovaginal candidiasis. More than half of the cases were in the age group of 21-30 years. Candida albicans was the most commonly identified species (71.1%), followed by C. glabrata (20.4%) and other non-C. albicans species (8.6%). Infection in pregnant women decreased in the third trimester compared to the first and second trimesters of pregnancy. Conclusions: Vulvovaginal candidiasis is a relatively common gynecologic problem in Ahvaz. Although the frequency of non-C. albicans species in VVC has increased, C. albicans is still the predominant species.

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Section: Discussionmentioning

confidence: 98%

“…Researchers believe that 5 -8% of adult women have RVVC (5,6,11). Several studies have shown that the frequency of VVC varies in different provinces of Iran, from 4.8 to 73% (12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Kiasat

Rezaei‐Matehkolaei

Mahmoudabadi

et al. 2019

Jundishapur J Microbiol

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“…Vulvovaginal candidiasis is one of the most common fungal infections among middle-aged Iranian women (Mahmoudabadi et al, 2010; Rad et al, 2011; Mohammadi-Ghalehbin et al, 2016; Rezaei-Matehkolaei et al, 2016). Several frequencies of the disease have been reported from different provinces in Iran including 62.1, 43.3, 40, 26, and 4.8% from Ilam, Babol, Arak, Hamadan, and Zanjan, respectively (Jamilian et al, 2007; Bahram et al, 2009; Esmaeilzadeh et al, 2009; Mohamadi et al, 2015; Habibipour, 2016).…”

Section: Introductionmentioning

confidence: 99%

Microsatellite Typing and Antifungal Susceptibility of Candida glabrata Strains Isolated From Patients With Candida Vaginitis

2019

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Vulvovaginal candidiasis (VVC) is a yeast infection with a global reach and millions of dollars are spent annually for its diagnosis and treatment. Recently, Candida glabrata with different degrees of antifungal resistance has been considered as the second most common cause of vaginal infections. The aim of the present study is to determine the antifungal susceptibility and molecular epidemiology profiles of C. glabrata isolates from patients with VVC. Sixty-one C. glabrata isolates were examined for antifungal susceptibility using the EUCAST broth microdilution method. Moreover, microsatellite length polymorphism (MLP) was used for typing the C. glabrata isolates using six microsatellite markers. Overall, 13, 3.3, and 0% of the isolates were non-wild types to itraconazole, posaconazole, and voriconazole, respectively. Sixty (98.4%) isolates were an intermediate phenotype to fluconazole and only one isolate was fluconazole resistant. Microsatellite length polymorphism with a discriminatory power of 0.964 identified 35 distinct types and 24 singleton genotypes. The assessment of the population genetic structure revealed that the non-wild-type population had a moderate genetic differentiation compared to the wild type population (F ST = 0.1457). It was also found that the most common genotypes were G27 (eight strains), G12 (six strains), and G4 (five strains). We found that eight strains were resistant/a non-wild phenotype to itraconazole. Five out of eight (62.5%) resistant/non-wild phenotype strains correlated to a predominant genotype (GT27) and the rest belonged to GT11 (12.5%), GT29 (12.5%), and GT28 (12.5%). The current study is the first molecular epidemiology study in the southwest of Iran and demonstrates the antifungal susceptibility profiles of C. glabrata in it. This study shows a wide range of the genetic diversity of C. glabrata (35 different genotypes) from VVC in the southwest of Iran. The majority of the non-wild isolates had a dominant genotype or genotypes related to this dominant genotype (clonal cluster one).

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“…According to Habibipour R, [17]C. albicans (81.3%) predominantly and then C. glabrata (11%), C. tropicalis (4.4%) and C. kuresi (2.2%) were isolated from VVC.…”

Section: Discussionmentioning

confidence: 99%

A study on Vulvovaginal candidiasis among non-pregnant women

Kavitha¹,

Mohan²,

Anandi³

et al. 2018

Trop J Pathol Microbiol

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Introduction: Candida species are opportunistic pathogens which cause a wide variety of infections in humans ranging from trivial intertriginous infection to fatal candidemia. Vulvo vaginal candidiasis (VVC) is an acute inflammatory disease and a frequent reason for gynaecological consultations. The present study aimed at determining prevalence of Candida species from VVC and to speciate isolated Candida with antifungal susceptibility profile among non pregnant women. Materials and Methods: This was a cross sectional study conducted over a period of six monthsin the department of microbiology and Obstetrics and Gynecology. Swabs collected from patients were subjected to microscopy (Gram s stain) and culture on Sabouraud's dextrose agar. Species level was identified by using chrome agar. Antifungal susceptibility testing: Antifungal susceptibility testing was performed by NCCLS M44-A Disc diffusion method. Results: A total of 209 high vaginal swabs were collected from non pregnant women. 71 patients high vaginal swabs yielded growth of Candida species and accounted for 33.97%. Most commonly isolated species were Candida albicans 31 (43.66%) followed by Candida tropicalis 27(38.03%) and Candida glabrata 13 (18.31%). All species were found to be susceptible to Amphotericin B. Among commonly used antifungals, clotrimazole was found to be most susceptible. But, C.glabrata species was least susceptible to frequently used antifungals. Conclusion: Candida albicans was the most commonly isolated species. CHRO Magar is rapid, technically simple and cost effective compared to time consuming technically demanding expensive conventional methods. Performing antifungal susceptibility is useful in choosing appropriate antifungal in treating vulvo vaginal candidiasis.

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Prevalence Rate of Vulvovaginal Candidiasis and Identification of Candida Species in Women in Referred to Hamedan Hospitals 2013 - 2014, West of Iran

Abstract: Background: Vulvovaginal candidiasis is a common gynecological finding among the women worldwide. Objectives: In this study determine of prevalence rate of vulvovaginal candidiasis and identification of Candida species was investigated.

Cited by 6 publications

References 10 publications

Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Prevalence of Vulvovaginal Candidiasis in Ahvaz, Southwest Iran: A Semi-Large Scale Study

Microsatellite Typing and Antifungal Susceptibility of Candida glabrata Strains Isolated From Patients With Candida Vaginitis

A study on Vulvovaginal candidiasis among non-pregnant women

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