“…Thus, newer-generation e-cigarettes and ENDS are now able to deliver much higher nicotine concentrations than combustible cigarettes without the traditional acerbic taste and inhalational effects commonly associated with combustible cigarettes. 86,87,[89][90][91][92] These devices have additional appeal among youths because they often have sleek, easily concealed designs resembling pens or USB devices or are even made to resemble smartphones, gaming devices, and popular cartoon characters. 86,87,93 Furthermore, newer-generation salt-based nicotine e-liquids are available in a host of attractive fruity, minty, and candy-based flavors that hold appeal for youthful users, which can further mask subjective caustic initial effects of higher-dose nicotine inhalation, 86,87,94 are associated with an increased odds of adolescent vaping continuation (aOR ¼ 3.76; 95% CI, 1.20-10.31) and a higher level of nicotine-containing puffs taken on each vaping event (mean, 3.1 AE 5.5 vs 1.5 AE 3.8), compared with the use of unflavored tobacco or menthol flavors among youths who use e-cigarettes.…”