Prevalence of yeast in diabetic foot infections

Sugandhi, Pugazhendhi; Prasanth, Dorairaj Arvind

doi:10.1007/s13410-016-0491-8

Cited by 4 publications

(3 citation statements)

References 25 publications

(26 reference statements)

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“…The low incidence of resistance to amphotericin B in our study and previous similar studies could be explained by the fact that the agent is not commonly used among diabetic patients due to hypokalemia-associated nephrotoxicity. Our findings contrasts with those from other studies done in different parts of the world that reported up to 100% susceptibility rate of amphotericin B to Candida species [ 38 - 41 ]. Resistance to polyenes in Candida species may be associated with defective C5, 6-desaturase functionality in C. albicans and mutation of ERG 2, 3, 5, 6 and 11 genes involved in ergosterol cell membrane synthesis.…”

Section: Discussioncontrasting

confidence: 99%

Speciation and antifungal susceptibility of Candida isolates from diabetic foot ulcer patients in a tertiary hospital in Kenya

Musyoki¹,

Mutai²,

Ngugi³

et al. 2022

Pan Afr Med J

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Introduction diabetic foot ulcer is the leading cause of hospital admissions, lower limb amputation and death among diabetic patients. Little information is available on fungal isolation in diabetic foot ulcer patients, especially in sub-Saharan Africa. This study aimed to describe Candida species infecting diabetic foot ulcers in patients receiving clinical care at Kenyatta National Hospital and assess their antifungal susceptibility profile. Methods this was a cross-sectional study carried out at Kenyatta National Hospital among adult diabetic foot ulcer patients over a three-month period. Species identification of Candida was performed using VITEK - 2 System and further confirmed by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. Antifungal susceptibility testing was determined using VITEK-2 System. Data were analysed using WHONET and SPSS. Results among the 152 study patients recruited, 98% (n=149) had type 2 diabetes. Sixty one percent of the participants were male. The mean age of the study participants was 50.7 years (SD 12.9). A total of 36 Candida species were isolated, of which 75% (n=27) were Candida albicans. Candida lusitaniae (8%, n=3) and C. dubliniensis (5%, n=2) were the predominant non-albicans Candida species. The overall prevalence of diabetic foot ulcer candidiasis was 20% (n=31). C. albicans isolates (26%) were resistant to caspofungin, fluconazole, micafungin, and voriconazole but highly susceptible to amphotericin B and flucytosine (81-96%). Non-albicans Candida species isolated were susceptible (90-100%) to a majority of the antifungal agents tested. Conclusion Candida albicans was the predominant species isolated and showed low resistance rates to the commonly administered antifungal agents. There is need to include fungal diagnosis in the investigation of diabetic foot ulcer infection.

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Section: Discussioncontrasting

confidence: 99%

Speciation and antifungal susceptibility of Candida isolates from diabetic foot ulcer patients in a tertiary hospital in Kenya

Musyoki¹,

Mutai²,

Ngugi³

et al. 2022

Pan Afr Med J

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“…(27) The results of our study showed that the prevalence of dermatomycosis tends to be higher in uncontrolled diabetic patients than in controlled ones. This result is in concordance with Sugandhi et al (28) in that poor glycemic control was significantly associated with fungal infection. Type 2 diabetes was previously known as predisposing factor for fungal infection especi al l y Candida infection and dermatophytosis of the foot and nail.…”

Section: Discussionsupporting

confidence: 93%

Uncontrolled blood sugar tends to increase prevalence of dermatomycosis in diabetic type 2 patients

et al. 2018

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Background The prevalence of type 2 diabetes mellitus (DM) is increasing. Diabetic patients have a higher risk of getting dermatomycosis. Dermatomycoses, although a common health problem amongst DM, is often misdiagnosed and consequently undertreated. Studies on the association between dermatomycosis and type 2 diabetes are lacking, especially in Indonesia. Therefore, the aim of this study was to determine the prevalence, etiology, and association of dermatomycosis with diabetic control of type 2 DM. Methods A cross-sectional study was performed involving 87 subjects with type 2 DM. Demographic and clinical data, including age, sex, and blood glucose level, were collected. If a dermatomycosis lesion was found, a specimen would be taken for identification. Determination of serum glucose level was conducted using Roche c111 analyzer®. Statistical analysis was performed with the chi-square test and Kolmogorov-Smirnov two-independent sample test. Results Seventeen (19.55%) subjects had dermatomycosis. The predominant age group affected was 51 - 60 years (42.4%). The number of clinically apparent dermatomycosis was greater in the uncontrolled than in the controlled blood sugar group, but the difference was statistically not significant (p > 0.05). The lesions were mostly found on the nails (74%) and the most common etiology was candida (50%) followed by dermatophyte (25%) and non-dermatophyte molds (25%). Conclusion Uncontrolled blood sugar tends to increase the risk of dermatomycosis in type 2 DM patients. Fungal skin infections are common in type-2 DM patients, especially in those with poor glycemic control.

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“…Rasoulpoor et al reached a similar finding in their systematic review analysis, stating that the rate of fungal infection in DFU was higher in elderly individuals [12]. Another study published in 2017 by Sugandhi and Prasanth found that patients in the 51-60 years old age group were more susceptible to fungal infection in DFU due to their physical health conditions [13]. Diabetes duration also acts a vital function in the creation of diabetic foot ulcer and the increase in the occurrence of fungal infection.…”

Section: Discussionmentioning

confidence: 63%

Clinical Study of Coexistence of Fungal Infections in Diabetic Foot Ulcers by 18s rRNA Gene Polymerase Chain Reaction

Shalaby

Gaafar²,

Basshar³

et al. 2023

Open Access Maced J Med Sci

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BACKGROUND: Clinicians frequently ignore fungal infections in diabetic foot ulcers and do not regularly explore profound tissue from the injury for fungal culture and sympathy. AIM: The present study aimed to detect the etiologic substances and the regularity of fungal corruptions in ulcerated diabetic foot tissue samples utilizing two important diagnostic methods, namely, conventional microbiological methods and conventional 18s rRNA gene polymerase chain reaction (PCR) for detection of fungal foot infection. MATERIALS AND METHODS: One-hundred diabetic patients suffering from diabetic foot infections were enrolled in the present study. Deep tissue specimens from the depth of the wound were collected from the infected sites using aseptic techniques. Laboratory samples were examined, and morphophysiological methods identified pathogens to the species level. Fungi were detected in samples from infected sites using the PCR. RESULTS: The presence of fungal infection was detected in 17 (17%) of the 100 patients recruited in our study using conventional PCR. Conventional microbiological methods, on the contrary, revealed the presence of fungal infection in 14 patients (14%). Candida albicans was the most isolated pathogen (71%). CONCLUSION: In patients with chronic diabetic foot ulcers that are not responding to long-term antibiotic treatment, fungal pathogens should be considered. Early recognition of fungal corruptions in high-risk persons is serious for avoiding severe outcomes, that is, as foot amputation.

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Prevalence of yeast in diabetic foot infections

Cited by 4 publications

References 25 publications

Speciation and antifungal susceptibility of Candida isolates from diabetic foot ulcer patients in a tertiary hospital in Kenya

Speciation and antifungal susceptibility of Candida isolates from diabetic foot ulcer patients in a tertiary hospital in Kenya

Uncontrolled blood sugar tends to increase prevalence of dermatomycosis in diabetic type 2 patients

Clinical Study of Coexistence of Fungal Infections in Diabetic Foot Ulcers by 18s rRNA Gene Polymerase Chain Reaction

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