Prevalence of weak D in northern hilly areas of Uttarakhand, India

Agarwal, Nitin; Chandola, Iva; Agarwal, Amit

doi:10.4103/0973-6247.106761

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…4 Various studies from different parts of India in different ethnic groups have shown weak D prevalence in range of .0075-0.25% among all persons and .09-7.6% among D negative persons (table-2). [14][15][16][17][18][19] Present study showed 0.54% weak D prevalence among Rh negative persons and .015% among all persons. Present study showed slightly higher weak D prevalence among Rh negative individuals.…”

Section: Resultsmentioning

confidence: 86%

Phenotypic expression of weak/variant D - Experience from a tertiary care center of Raipur (Chhattisgarh)

Srivastava¹

2018

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Introduction: Testing for Rh system is performed as a routine test in blood banks. Rh system is one of the most polymorphic blood group systems. Rh positivity and negativity refers to presence or absence of D antigen on the red cell surface because it is most immunogenic and clinically important. Sometimes categorization of a person into definite D positive or D negative becomes difficult because variable expression of D antigen can occur. This is known as weak D/ partial D. Clinically weak D or partial D are of concern because serologically, it presents as Rh negative but for recipients they behave as Rh positive with possible risk of alloimmunization. Therefore, present study was undertaken with an aim to know the frequency of weak D antigen among donors and recipients presenting to our blood bank. Material and Method: This was a one year observational hospital based study including recipients and donors. All patients were tested for Rh-D factor by commercially available monoclonal anti-D sera. The individuals who were found negative with anti-D were further investigated for weak D antigen by using indirect antiglobulin test using AHG sera by tube technique. Results: During study period a total of 37,943 blood samples, including donors and recipients were tested for Rh antigen. Out of total samples tested 1,094 (2.88 %) were Rh negative and remaining (97.12%) were Rh positive. Antiglobulin test yielded positive results for Du in 6 persons (0.54% of Rh negative and 0.015% of all subjects). Conclusion: Present study concluded that D U prevalence among individuals presenting at our blood bank is 0.54%. we recommend that serologic testing of all D negative patients and donors should proceed to antiglobulin phase for identification of weak D positive donors.

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Section: Resultsmentioning

confidence: 86%

Phenotypic expression of weak/variant D - Experience from a tertiary care center of Raipur (Chhattisgarh)

Srivastava¹

2018

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“…The incidence of weak D is higher in our study as compared to other Indian studies where the incidence is in the range of 0.09–0.189% which could be due to geographic variations. [ 2 3 4 ] Our results obtained are representative of entire Mumbai and Thane regions.…”

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confidence: 80%

The feeble antigen “Weak D”: Prevalence in a tertiary care hospital blood bank in Mumbai

et al. 2017

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“…5-12% of the Indian population is found to be Rh -negative. 4,5 An extensive 10-year study done in India shows that 7.19% of blood donors were Rh negative and the weak D variant among them was 0.01%. 3 Slightly lower values have been reported in a Korean study and higher values among Caucasians.…”

Section: Resultsmentioning

confidence: 99%

Weak RHD (Du ) Phenotypic Expression Among the Blood Donors and Recipients in Pesimsr, Kuppam

Sindhu¹,

Zayed²,

Manikyam³

et al. 2018

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BACKGROUNDRh blood group system is based on the presence or absence of the Rh antigen, often called the Rh factor, on the cell membranes of the red blood cells (erythrocytes).Some red cells possess the D antigen but it is expressed so weakly that the cells are not agglutinated directly by anti-D sera. An indirect antiglobulin test is necessary to identify patients with the Weak D (formerly known as D u ) phenotype. 1 Detecting the Rh blood group as well as D u testing among the Rh-negative individuals is important as the antibodies against Rh antigen can cause transfusion reaction and haemolytic anaemias.

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Prevalence of weak D in northern hilly areas of Uttarakhand, India

Cited by 10 publications

References 5 publications

Phenotypic expression of weak/variant D - Experience from a tertiary care center of Raipur (Chhattisgarh)

Phenotypic expression of weak/variant D - Experience from a tertiary care center of Raipur (Chhattisgarh)

The feeble antigen “Weak D”: Prevalence in a tertiary care hospital blood bank in Mumbai

Weak RHD (Du ) Phenotypic Expression Among the Blood Donors and Recipients in Pesimsr, Kuppam

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