Prevalence of vitamin D deficiency in Egyptian rheumatoid arthritis patients: correlation with disease activity, functional disability, and bone mineral density

Allam, Nashwa T.; Elwakd, Mohamed; El-Abd, Dina Mohamed; Dorgham, Dalia

doi:10.4103/1110-161x.140521

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…The results of this study agree with the previous, where these studies showed a low level of 25-OH Vitamin D in patients with RA compared with healthy controls [15,16]. Recently, low levels of 25-OH Vitamin D have been observed in RA patients and as known that Vitamin D is a stimulant for immune tolerance [17] and therefore Vitamin D deficiency affects immune tolerance, causing the development of autoimmune diseases (e.g., RA), Vitamin D is also known to have immune properties [18], so Vitamin D regulates the immune response through different mechanisms (e.g., stimulate regulatory T cells, decrease antigen presentation, and inhibit the pro-inflammatory T helper type 1 profile) [19,20] so, the cause of 25-OH Vitamin D deficiency in RA patients was due to several reasons; autoimmune diseases, which played a role in the low level of Vitamin D, and Vitamin D deficiency was associated with musculoskeletal pain [21,22], as well as found that RA patients treated with corticosteroids had a low level of Vitamin D, although the treatment of corticosteroids has a small effect on the level of Vitamin D, corticosteroids have lowered the level of Vitamin D in RA patients [23,24].…”

Section: Discussionsupporting

confidence: 93%

Prevalence of 25-Hydroxy Vitamin D Deficiency and Some Biochemical Parameters in Iraqi Patients With Rheumatoid Arthritis and Their Associations With Disease Activity

Al-Gebori

Alosami

Al-Hashimi

2020

Asian J Pharm Clin Res

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Objectives: The objectives of the study were to evaluate changes in 25(OH) Vitamin D levels and some biochemical parameters in rheumatoid arthritis (RA) patients compared with healthy controls and assess the correlation of 25-hydroxy Vitamin D, calcium, magnesium, and disease activity. Study the effects of anti-RA drugs on these biochemical parameters and also the role of supplements calcium and 25-OH Vitamin D in RA patients. Methods: This study conducted between 60 patients for RA and 20 healthy controls according to the American College of Rheumatology standards in 2010. In this study, 25-hydroxy Vitamin D was measured using an enzyme-linked immunosorbent assay, and also some biochemical parameters were measured with a spectrophotometer (Humalyzer 2000). Results: Serum 25(OH) Vitamin D, calcium, magnesium, and albumin levels were significantly lower in RA patients compared with healthy controls. Serum alanine aminotransferase aspartate aminotransferase levels were significantly increased in RA patients compared with healthy controls. The correlation was non-significantly among 25-hydroxy Vitamin D and clinical disease activity index (CDAI), while the results showed significantly inverse correlation calcium and magnesium concentrations with CDAI. Conclusion: 25-OH Vitamin D, calcium, albumin, and magnesium deficiency appear to be widespread in patients with RA. Thus, biochemical changes in RA are reflected in the pathogenesis of RA. Furthermore, in these results, there is no relationship between Vitamin D and the disease activity, while there is a relationship between calcium and magnesium with disease activity.

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Section: Discussionsupporting

confidence: 93%

Prevalence of 25-Hydroxy Vitamin D Deficiency and Some Biochemical Parameters in Iraqi Patients With Rheumatoid Arthritis and Their Associations With Disease Activity

Al-Gebori

Alosami

Al-Hashimi

2020

Asian J Pharm Clin Res

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“…Vitamin D and IPF have a statistically significant inverse relationship, according to Allam et al (r=0.234, P=0.017). 3 In a previous study of 67 patients with ILD secondary to connective tissue disease including RA and 51 patients with other causes of ILD, significant vitamin D deficiency (52 vs. 20%,P<0.0001) and insufficiency (79 vs. 31%, P<0.0001) were found among those with connective tissue disease-ILD than those with other forms of ILD. 2 Our study agrees with that done by Sherin et al 8 which showed an association between pulmonary affection in RA patients and hypovitaminosis D as in RA patients with pulmonary affection 45% of patients have vitamin D deficit and 45% had vitamin D insufficiency versus 16.7 and 63.3% in RA patients without pulmonary affection.…”

Section: Discussionmentioning

confidence: 82%

“…The presence of its receptors on several types of cells supports this, and its insufficiency is linked to the progression and result of RA. 3 According to a 2012 Greek study published in Therapeutic Advances in Endocrinology and Metabolism, vitamin D insufficiency is closely linked to disabling symptoms in people with rheumatoid arthritis. This could be because RA can impair the body's ability to absorb vitamin D from the foods we eat, and low vitamin D levels can exacerbate RA symptoms and pain.…”

Section: Introductionmentioning

confidence: 99%

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The association between Vitamin D Deficiency and Pulmonary Affection in Rheumatoid Arthritis Patients

Ahmed¹,

GHAIT²,

Basiony³

et al. 2022

Al-Azhar International Medical Journal

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Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease causing symmetrical articular destruction with extraarticular manifestations that include pulmonary manifestations, which are major contributors to morbidity and mortality. Aim of The Work:To detect the prevalence of vitamin D deficiency and its relationship to pulmonary affection in RA patients and correlate it with disease Activity . Patients and Methods:The study is a cross sectional one, carried out on fifty patients with RA recruited from the Chest and Rheumatology Outpatient Clinics of Al Hussein University Hospital. All patients diagnosed with RA who fulfilled the American Colleague of Rheumatology/European League against Rheumatism 2010 classification criteria. Results: In our study there was statistically significant (p-value = 0.002) increased DAS score in deficient patients (5.4 ± 0.8) when compared with insufficient patients (4.9 ± 0.4) and sufficient patients (4.1 ± 0.8). In our study there was statistically significant relation (p-value < 0.05) between vitamin D status and pulmonary manifestations (Exertional Dyspnea, Dry Cough, Chest Pain, Wheezing and Leathery Crepitation) which more frequent in deficient than insufficient and sufficient patients. In our study there was highly statistically significant (p-value < 0.001) decreased FVC in deficient patients (89.3 ± 20.1) when compared with insufficient patients (113.4 ± 7.1) and sufficient patients (114.8 ± 3.4). No statistically significant relation (p-value > 0.05) between vitamin D status and FEV1 & FEV1/FVC. Conclusion: RA disease activity score (DAS-28 score) and pulmonary manifestations in RA patients were more prevalent in Vitamin D deficient than insufficient and sufficient patients.

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“…The prevalence of hypovitaminosis D in this region varies from 30 to 90%, considering a desirable 25-OH-vitamin D level of 20 ng/ml [24]. These deficient levels might be attributed to decreased sun exposure (conservative dressing culture and/or avoidance of exposure to hot sunny weather) [25]. Also, the food fortification policy is nearly absent in the majority of this region [24].…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

Abdelmotaleb

Behairy

Azim

et al. 2021

Egypt Pediatric Association Gaz

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Background Beta-thalassemia major patients are at increased risk of complications including endocrinopathies and bone disease due to iron overload. So, this study aimed to assess the growth parameters, serum levels of 25-OH-vitamin D, calcium, and phosphorous in children with beta-thalassemia major. This was a case-control study that included 55 children with beta-thalassemia major compared with 30 sex- and age-matched healthy children that served as a control group. All enrolled children were subjected to full history taking, clinical examination including anthropometric measurements, and laboratory investigations including complete blood count, serum ferritin, levels of serum calcium, phosphorus, and 25-OH-vitamin D. Results Body mass index was statistically significantly lower in the thalassemic group (P < 0.001). It was observed that vitamin D levels were significantly lower in thalassemic patients than in controls (P value < .0001). The mean serum 25-OH-vitamin D levels were 19.84 ± 5.79 ng/ml and 44.98 ± 5.77 ng/ml, respectively; 22 cases (40%) had insufficient vitamin D, and 5 cases (9%) had deficient vitamin D. Regarding serum calcium and phosphorous, there was no significant difference between the thalassemic and control groups. Conclusion Children with beta-thalassemia major had low body mass index and metabolic abnormality in the form of lower serum levels of vitamin D that signify the importance of therapeutic interventions.

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Prevalence of vitamin D deficiency in Egyptian rheumatoid arthritis patients: correlation with disease activity, functional disability, and bone mineral density

Cited by 5 publications

References 35 publications

Prevalence of 25-Hydroxy Vitamin D Deficiency and Some Biochemical Parameters in Iraqi Patients With Rheumatoid Arthritis and Their Associations With Disease Activity

Prevalence of 25-Hydroxy Vitamin D Deficiency and Some Biochemical Parameters in Iraqi Patients With Rheumatoid Arthritis and Their Associations With Disease Activity

The association between Vitamin D Deficiency and Pulmonary Affection in Rheumatoid Arthritis Patients

Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

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