Prevalence of 25-Hydroxy Vitamin D Deficiency and Some Biochemical Parameters in Iraqi Patients With Rheumatoid Arthritis and Their Associations With Disease Activity

Al-Gebori, Abdulnasser M.; Alosami, Mohammed H.; Al-Hashimi, Nawal Haider

doi:10.22159/ajpcr.2020.v13i4.36759

Cited by 2 publications

(2 citation statements)

References 35 publications

(39 reference statements)

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“…As a result, vitamin D regulates the immune response through a variety of pathways (e.g., stimulate regulatory T cells, decrease antigen presentation, and inhibit the pro-inflammatory T helper type 1 profile) [16]. Thus, autoimmune diseases, which contributed to the low level of Vitamin D, and Vitamin D deficiency was linked to musculoskeletal pain, as well as finding that RA patients treated with corticosteroids had a low level of Vitamin D, even though the use of corticosteroids has a minimal impact on the level of Vitamin D, corticosteroids have decreased the level of Vitamin D in RA patients [17]. Regression analysis showed an inverse highly significant relationship between anti-dsDNA and vitamin D. Increased anti-dsDNA level associated with low vitamin D level as shown in Figure 1.…”

Section: Determination Of 25-hydroxy Vitamin D (25[oh]d) C3 and C4mentioning

confidence: 99%

Vitamin D deficiency Associates with Disease Severity in Rheumatoid Arthritis Patients

Al-Sarray¹,

Al-Hafidh²,

Al-Rayahi³

2023

Al-Mustansiriyah Journal of Science

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Vitamin D considered as a key player in various autoimmune disorders, such as rheumatoid arthritis, due to its immunological modulatory effect. Together with Anti-double stranded DNA (Anti-dsDNA), Anti-cyclic citrullinated peptide (Anti-CCP) is considered among the indicators of the disease severity in rheumatoid arthritis. The present study aimed to measure the level of vitamin D in RA patients besides measuring anti-dsDNA, anti-CCP, RF, complete blood count (CBC) and Erythrocyte Sedimentation Rate (ESR) for comparing it with its corresponding level in healthy control group. This study was a descriptive cross-sectional study involving sequential RA patients who visited the Rheumatology clinic for outpatients during three-months period starting from July 2018, at the Baghdad Teaching Hospital. Sixty individuals (30 RA patients and 30 age and gender matched healthy control) were enrolled in this study. Blood samples were collected and serum levels of anti-dsDNA, 25-hydroxy vitamin D (25[OH]), anti-CCP and RF besides C3, C4, CBC and ESR were measured. A highly significant decrease was displayed in the mean level of vitamin D in RA patients (18.67±17.70 ng/mL) when compared to its level in the control group (35.07 ±3.71 ng/mL), (normal value: 20 and 40 ng/mL), whereas, anti-dsDNA level normal value: (<30.0 IU/mL) was significantly increased in RA patients (122.27±65.89 IU/ml) as compared to its mean level in the control group (17.77±3.56 IU/ml) with an inverse relationship between anti-dsDNA levels vitamin D levels in RA patients. No statistical difference noted in C3 and C4 levels between patients and control groups. Rheumatoid arthritis patients with positive RF had statistically higher anti-CCP (normal value: less than 20 U/ml) than those with negative RF (39.83±11.449 vs 21.67±4.658 u/ml). As expected, a highly significant increase was observed in ESR of patients when compared to that of the control. In addition, an alteration was noted in some circulating blood cells count.

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Section: Determination Of 25-hydroxy Vitamin D (25[oh]d) C3 and C4mentioning

confidence: 99%

Vitamin D deficiency Associates with Disease Severity in Rheumatoid Arthritis Patients

Al-Sarray¹,

Al-Hafidh²,

Al-Rayahi³

2023

Al-Mustansiriyah Journal of Science

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“…Through a variety of mechanisms, TN-C promotes both adaptive and innate immune responses in arthritic joints. TN-C's C-terminal gFG induces the pro-inflammatory cytokines and chemokines release in autoimmune disease patients such as RA [10], which increases the risk of osteoporosis around the afflicted joint, erosive synovitis, bone damage, and cartilage deterioration [11,12].…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C and Interleukin-17 Up-regulation in Axial Spondyloarthritis Patients

Al-Hindawi¹,

Al-Gebori²,

Alosami³

2023

RBJ

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Background: Axial spondyloarthritis (axSpA) is an inflammatory, systemic rheumatic condition that mostly affects the axial skeleton. Tenascin-C (TN-C) is a hexameric glycoprotein of considerable size, upregulated in many inflammatory conditions, while Interleukin-17 (IL-17) a cytokine that plays an important role in SpA symptoms. Objective: to investigate the upregulation between the serum levels of TN-C and IL-17 in Iraqi axSpA patients and the disease characteristics. Patients and Methods: Seventy-four axSpA patients and 28 matched controls were studied. Fifty-four patients received a tumor necrosis factor inhibitor (TNFi) and 20 did not. Serum TN-C and IL-17 concentrations were determined using the ELISA technique. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was assessed. For statistical tests, Chi Square, Mann Whitney, Independent Samples T, and Pearson's correlation tests are used. Results: Patients mean age was 35.6±0.9 years, 65 males and 9 females, and disease duration was 5.18±0.6 years. 47.4% were smokers, 47% had inflammatory low back pain, and HLA-B27 was present in 91%. BASDAI mean was 6.1±0.4 in non-TNFi and 2.6±0.3 in those on TNFi. The serum TN-C concentration was significantly increased in patients, especially those on non-TNFi (79±9.6 pg/mL) compared to those on TNFi (69.1±3.2 pg/mL) and control (53±3.9 pg/mL) (p=0.003). Serum IL-17 was significantly elevated in those receiving TNFi (877.9±257 pg/mL) compared to non-TNFi (487.2±234 pg/mL) and control (182.4±36.6 pg/mL) (p=0.033). The TN-C significantly correlated with erythrocyte sedimentation rate (r=0.27, p=0.02) and with hemoglobin (Hb) concentration (r=0.26, p=0.02). TN-C and IL-17 were non-significantly related (r=0.14, p=0.2). Conclusions: axSpA Patients demonstrated high levels of serum TN-C, particularly in those not receiving TNFi, and high IL-17 levels in those receiving TNFi, suggesting that there is an association with tissue injury from the disease and stimulation of immunological and resident tissue cells. Patients who had not received TNFi showed significantly higher disease activity than others.

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Prevalence of 25-Hydroxy Vitamin D Deficiency and Some Biochemical Parameters in Iraqi Patients With Rheumatoid Arthritis and Their Associations With Disease Activity

Cited by 2 publications

References 35 publications

Vitamin D deficiency Associates with Disease Severity in Rheumatoid Arthritis Patients

Vitamin D deficiency Associates with Disease Severity in Rheumatoid Arthritis Patients

Tenascin-C and Interleukin-17 Up-regulation in Axial Spondyloarthritis Patients

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