Prevalence of vitamin D deficiency and its association with metabolic derangements among children with obesity

Adikaram, S G S; Samaranayake, Dulani; Kendaragama, K. M. D. L. D.; Senevirathne, J. T. N.; Wickramasinghe, V. Pujitha

doi:10.1186/s12887-019-1558-8

Cited by 20 publications

(25 citation statements)

References 34 publications

(31 reference statements)

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“…In the present study, as several authors have described [21,27,[34][35][36], we found a significant inverse association between serum 25(OH)D concentrations and serum insulin and HOMA-IR. Observational studies have detected that lower 25(OH)D levels are associated with a higher prevalence of impaired glucose tolerance or diabetes type 2 [37][38][39].…”

Section: Discussionsupporting

confidence: 83%

“…On the other hand, several observational studies have revealed an inverse relationship between 25(OH)D levels and BMI in children with obesity [8,27,41]. However, as we observed in this study, other authors have not found such an association [21,42]. We found an inverse correlation of serum 25(OH)D concentrations with different anthropometric and biochemical measurements that are specific of adiposity, such as body fat percentage, fat mass index, and leptin.…”

Section: Discussioncontrasting

confidence: 52%

“…In order to evaluate insulin resistance, the HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) indexes were calculated from fasting glucose and insulin concentrations (glucose levels in mmol × insulin in µUmL/22.5). An HOMA-IR value equal to or higher than 2.5 was considered to be insulin resistance [21].…”

Section: Metabolic Studymentioning

confidence: 99%

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Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

et al. 2020

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Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity. Subjects/Methods. A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2-15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status. Results. Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation (p < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH. Conclusions. Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance.

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Section: Discussionsupporting

confidence: 83%

Section: Discussioncontrasting

confidence: 52%

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Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

et al. 2020

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“…From previous studies, less vitamin D intake has a strong connection with obesity and diabetes . And the prevalence of vitamin D deficiency was very high among obese children . In a word, vitamin D deficiency is a risk factor of CRC, and it also has an influence on body weight.…”

Section: Discussionmentioning

confidence: 99%

Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder

Zhou

Chen

Zhong

et al. 2019

J of Gastro and Hepatol

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Background To investigate the correlation between the level of circulating vitamin D and the development of colorectal cancer (CRC) and to clarify the effect and mechanism of vitamin D on the development of CRC. Methods Serum samples from 63 patients with CRC (CRC group) and 61 healthy volunteers (normal group) were collected. Azoxymethane + dextran sodium sulfate‐induced CRC mouse model and dietary models with different doses of vitamin D were established to verify whether vitamin D supplementation could reverse the occurrence and development of CRC at the overall animal level. Intestinal barrier integrity and microbial defense response were evaluated by detection of intestinal flora and expression of related genes. Results In the clinical serum samples, compared with the normal group, the level of 25 (OH) D3 in the CRC group was relatively low (P < 0.01), which was consistent with the clinical situation in mice. Vitamin D deficiency aggravated the deterioration of enteritis and intestinal cancer in CRC mice, whereas the overall condition of CRC mice improved after vitamin D supplementation. Vitamin D has a significant regulatory effect on the homeostasis of the intestinal flora, particularly in the regulation of intestinal probiotics, Akkermansia muciniphila‐mediated colon barrier integrity. Conclusions Vitamin D deficiency is closely related to the high incidence of CRC, and vitamin D supplementation can inhibit the occurrence and development of CRC. Vitamin D plays a role in the reversal of CRC mainly through the regulation of intestinal flora, especially the regulation of A. muciniphila‐mediated colon barrier integrity.

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“…Such techniques allows to recover the internal structure of on-shell particles from scattering of off-shell ones [7]. In the future, this gap may be bridged by the tagged DIS experiment at the upgraded Jefferson Laboratory (JLab 12) [8], and possibly kaon as well.…”

Section: Introductionmentioning

confidence: 99%

Pion and kaon valence quark distribution functions from Dyson-Schwinger equations

2018

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Using realistic quark propagators and meson Bethe-Salpeter amplitudes based on the Dyson-Schwinger equations, we calculate the pion and kaon's valence parton distribution functions (PDF) through the modified impulse approximation. The PDFs we obtained at hadronic scale have the purely valence characteristic and exhibit both dynamical chiral symmetry breaking and SU (3) flavor symmetry breaking effects. A new calculation technique is introduced to determine the valence PDFs with precision. Through NLO DGLAP evolution, our result is compared with pion and kaon valence PDF data at experimental scale. Good agreement is found in the case of pion, while deviation emerges for kaon. We point out this situation can be resolved by incorporating gluon contributions into the mesons if the pion hosts more gluons than kaon nonperturbatively.

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Prevalence of vitamin D deficiency and its association with metabolic derangements among children with obesity

Cited by 20 publications

References 34 publications

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder

Pion and kaon valence quark distribution functions from Dyson-Schwinger equations

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