Prevalence of vesicoureteral reflux in patients with incidentally diagnosed adult hypertension

Barai, Sukanta; Bandopadhayaya, G. P.; Bhowmik, D; Patel, Chetan; Malhotra, Arun; Agarwal, Palkesh; Singhal, Tanu

doi:10.1016/j.urology.2003.12.051

Cited by 20 publications

(14 citation statements)

References 21 publications

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“…Although there are no data available on the presence of VUR in the Freedman et al study, it is conceivable that gene(s) in this region may contribute to both renal function and anatomy. VUR may be associated with hypertension 73. This locus, therefore, may be worthy of further examination in both syndromic and nonsyndromic VUR.…”

Section: Monogenic Diseases and Renal Involvementmentioning

confidence: 97%

Genetic contribution and associated pathophysiology in end-stage renal disease

Agrawal

Agarwal²,

Naik³

2010

TACG

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End-stage renal disease (ESRD) or chronic kidney disease (CKD) is the terminal state of the kidney when its function has been permanently and irreversibly damaged. A wide variety of etiologies and pathological processes culminate in ESRD, and both environmental and genetic factors contribute to its development and progression. Various reports suggest that susceptibility to develop ESRD has a significant genetic component. These studies include familial aggregation studies, comparisons of incidence rates between different racial or ethnic populations, and segregation analysis. Genetic approaches have been used to identify genes that contribute to genetic susceptibility. Many studies have now been carried out assessing the contribution of specific "candidate genes", which correlate with different functions that are involved in the renal pathogenesis. Independent studies for specific associated genes have frequently provided contradictory results. This may be due, in part, to the modest contribution to genetic susceptibility which these genes impart. With the availability of different genomewide association studies, chromosomal regions harboring novel, previously unrecognized, genes that may contribute to renal diseases have been recently reported. We have focused on different genetic studies conducted on ESRD and have discussed the strength and weaknesses of these studies. The nonmuscle myosin heavy chain 9 gene (MYH9) and renin-angiotensin system (RAS) have been discussed in detail.

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Section: Monogenic Diseases and Renal Involvementmentioning

confidence: 97%

Genetic contribution and associated pathophysiology in end-stage renal disease

Agrawal

Agarwal²,

Naik³

2010

TACG

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“…Typically, VUR is asymptomatic with a high rate of spontaneous resolution [2]. However, a significant proportion of untreated patients develop kidney infections with consequential pyelonephric scarring and hypertension [3,4]. Given the potential morbidity of both observation and treatment, there is significant debate regarding the necessity of medical therapy to prevent infection and surgical therapy to correct reflux itself [5e7].…”

Section: Introductionmentioning

confidence: 99%

Quality of life in children with vesicoureteral reflux as perceived by children and parents

Yao

Weinberg

Penna

et al. 2011

Journal of Pediatric Urology

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“…Although there are no data available on the presence of VUR in the Freedman et al study, it is conceivable that gene(s) in this region may contribute to both renal function and anatomy. VUR was documented recently to be not an infrequent finding in adults with incidentally diagnosed hypertension from an Indian cohort of patients (6). This locus therefore may be worthy of further examination in both syndromic and nonsyndromic VUR.…”

Section: Discussionmentioning

confidence: 85%

“…Although CAKUT accounts for approximately 0.5% of all pregnancies, the true incidence of CAKUT probably is much higher (3)(4)(5)(6)(7). Almost 30% of children who present with urinary tract infection (UTI) may have VUR.…”

mentioning

confidence: 99%

A Locus for Renal Malformations Including Vesico-Ureteric Reflux on Chromosome 13q33–34

Vats¹,

Ishwad²,

Singla³

et al. 2006

Journal of the American Society of Nephrology

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Congenital anomalies of kidney and urinary tract (CAKUT), including vesico-ureteric reflux (VUR), are major causes of ESRD in childhood. Herein is reported evidence for a locus on 13q33q34 associated with CAKUT. Deletion mapping of chromosome 13q was performed in four children with CAKUT using 31 microsatellite markers on peripheral blood genomic DNA that was obtained from the patients and their parents. mRNA expression of the positional candidate genes was compared with sequences in electronic databases in silico and also studied in adult and fetal mouse kidneys using reverse transcription-PCR. The children (three girls; age range 5 to 17 yr) had varying severity of developmental delay and other organ system involvement. The spectrum of CAKUT included high-grade VUR (n ‫؍‬ 2), renal dysplasia (n ‫؍‬ 2), and hydronephrosis (n ‫؍‬ 1). Both the children with VUR had evidence of renal failure with one of them developing ESRD. Deletion mapping identified a 7-Mb critical region flanked by markers D13S1311 and D13S285. There are 33 genes (12 known; 21 computer predicted) in this region. In silico expression studies showed matches for 14 of these genes in the kidneys and 10 in the bladder expressed sequenced tags databases. Mouse kidney studies showed that of the 24 genes examined, several had variable expression through the different stages of renal development, whereas five of the genes were not expressed at all. Herein is reported a new locus on chromosome 13q33q34 that can be associated with VUR with several genes showing mRNA expression patterns that suggest their potential for involvement in renal/urinary tract developmental anomalies.

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Prevalence of vesicoureteral reflux in patients with incidentally diagnosed adult hypertension

Cited by 20 publications

References 21 publications

Genetic contribution and associated pathophysiology in end-stage renal disease

Genetic contribution and associated pathophysiology in end-stage renal disease

Quality of life in children with vesicoureteral reflux as perceived by children and parents

A Locus for Renal Malformations Including Vesico-Ureteric Reflux on Chromosome 13q33–34

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