Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis.

Ralston, S. H.; Urquhart, G. D. K.; Brzeski, M; Sturrock, R D

doi:10.1136/bmj.300.6724.563

Cited by 157 publications

(63 citation statements)

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“…Bony overgrowth in AS has been considered a structural damage arising from chronic immune activation and inflammation, [3] although the link between inflammation and ankylosis is not completely understood in this disease. [3,4] A study by Ralston et al [5] emphasized the difference between the processes taking place in cortical versus trabecular bone in AS. While trabecular bone mass decreases, leading to vertebral osteoporosis, specific sites of the cortical bone start to proliferate and expand.…”

Section: Introductionmentioning

confidence: 99%

“…While trabecular bone mass decreases, leading to vertebral osteoporosis, specific sites of the cortical bone start to proliferate and expand. [5,3] In general, AS is associated with bone loss in the vertebrae and an increased prevalence of vertebral fractures. [6,7] Cooper et al [6] identified markedly increased relative risk of vertebral morphometric deformities in patients with AS compared with the control population.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ivanova

Manolova

Boyadzhieva

et al. 2015

Biotechnology & Biotechnological Equipment

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(2015) Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients, Biotechnology & Biotechnological Equipment, 29:5, 956-962, DOI: 10.1080/13102818.2015 This study aimed to evaluate the relationship between physical function, disease activity, spinal mobility and bone parameters in ankylosing spondylitis (AS) patients. Fifty patients (27 men and 23 women) were examined. The clinical assessment included Bath AS Disease Activity Index, AS Disease Activity Score, Bath AS Functional Index, Bath AS Metrology Index (BASMI). Lumbar spine and femoral neck bone mineral density (BMD), spinal trabecular bone score (TBS) and the TBS T-score were calculated by dual-energy X-ray absorptiometry. Prevalence rates for osteoporosis and osteopaenia were 14% and 36%, respectively and for partially and fully degraded microarchitecture À 34% and 16%, respectively. A similar inverse correlation was observed between BASMI and TBS, TBS T-score and femoral BMD bone parameters, which were significantly lower in patients 45 years of age. No significant correlations were detected between any bone parameter and indicators of disease activity and physical function. Patients with a disease duration of 10 years tended to exhibit either normal or elevated spine BMD. Femoral BMD was lower in men. The higher BASMI was associated with an increased likelihood of TBS < 1.350 (odds ratio (OR) D 1.44, 1.05À1.97, p D 0.024) and TBS T-score < À1.00 (OR D 1.55, 1.11À2.16, p D 0.01). In summary, lumbar spine BMD can be erroneously influenced by osteoproliferation, unlike the TBS and TBS T-score. The limitations in spinal mobility predicted abnormal results for these two TBS parameters. TBS may be a better indicator of bone health than BMD in AS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ivanova

Manolova

Boyadzhieva

et al. 2015

Biotechnology & Biotechnological Equipment

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“…Accordingly, osteoporotic fractures are more prevalent in patients with AS than in the general population [2][3][4]. Due to the formation of paravertebral calcification false interpretation of spine bone density measured by dual-energy x-ray absorptiometry (DXA) can occur.…”

Section: Introductionmentioning

confidence: 99%

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

et al. 2011

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SummaryAim. In ankylosing spondylitis (AS) inflammatory activity probably plays a key role in the pathophysiology of bone loss. The aim of the study was to investigate the relationship of bone mineral density (BMD) at the lumbar spine and hip region with some measures of disease activity and functional ability in patients with ankylosing spondylitis.Methods: In 80 patients with established ankylosing spondylitis disease activity and functional ability were determined by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Spinal pain and patient global health were assessed using horizontal visual analogue scale (VAS). BMD was measured by dual-energy x-ray absorptiometry (DXA).Results. There was a significant negative correlation of bone density T scores with acute phase reactants (i.e. patients with lower T scores had higher level of CRP and ESR). That relationship was reflected more reliably at proximal femur sites than at the lumbar spine.There were also significant differences in ESR, BASDAI, BASFI, spinal pain and global health between three groups of patients according to WHO classification of osteoporosis (normal, osteopenic and osteoporotic). Significantly more patients with osteopenia at the lumbar spine had lower BASDAI index than those with normal BMD (p=0.030). Conclusion:Our results indicate an association of low BMD with high disease activity in patients with AS. Femoral BMD seems to be more associated with disease activity and functional ability than lumbar spine BMD.

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“…For example, abdominal exercises that actively flex the trunk may be problematic for individuals with lumbar disk pathologies due to increased intradiscal pressure 18 and lumbar spine compression, 3 and for individuals with osteoporosis due to the risk of vertebral compression fractures. 21 However, these same individuals may be asymptomatic during abdominal exercises that maintain a relatively neutral spine and pelvis. In contrast, individuals with facet joint syndrome, spondylolisthesis, and vertebral or intervertebral foramen stenosis may not tolerate exercises such as the Ab Slide and Torso Track due to the extended spine position.…”

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confidence: 99%

An Electromyographic Analysis of Commercial and Common Abdominal Exercises: Implications for Rehabilitation and Training

Escamilla

Mctaggart²,

Fricklas³

et al. 2006

J Orthop Sports Phys Ther

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Study Design: A repeated-measures, counterbalanced design. Objectives: To test the effectiveness of 7 commercial abdominal machines (Ab Slide, Ab Twister, Ab Rocker, Ab Roller, Ab Doer, Torso Track, SAM) and 2 common abdominal exercises (crunch, bent-knee sit-up) on activating abdominal and extraneous (nonabdominal) musculature. Background: Numerous abdominal machine exercises are believed to be effective in activating abdominal musculature and minimizing low back stress, but there are minimal data to substantiate these claims. Many of these exercises also activate nonabdominal musculature, which may or may not be beneficial. Methods and Measures: A convenience sample of 14 subjects performed 5 repetitions for each exercise. Electromyographic (EMG) data were recorded for upper and lower rectus abdominis, external and internal oblique, pectoralis major, triceps brachii, latissimus dorsi, lumbar paraspinals, and rectus femoris, and then normalized by maximum muscle contractions. Results: Upper and lower rectus abdominis EMG activities were greatest for the Ab Slide, Torso Track, crunch, and Ab Roller, while external and internal oblique EMG activities were greatest for the Ab Slide, Torso Track, crunch, and bent-knee sit-up. Pectoralis major, triceps brachii, and latissimus dorsi EMG activities were greatest for the Ab Slide and Torso Track. Lumbar paraspinal EMG activities were greatest for the Ab Doer, while rectus femoris EMG activities were greatest for the bent-knee sit-up, SAM, Ab Twister, Ab Rocker, and Ab Doer. Therapy, 6000 J Street, Sacramento, Conclusions: The Ab Slide and Torso Track were the most effective exercises in activating abdominal and upper extremity muscles while minimizing low back and rectus femoris (hip flexion) activity. The Ab Doer, Ab Twister, Ab Rocker, SAM, and bent-knee sit-up may be problematic for individuals with low back pathologies due to relatively high rectus femoris activity. J Orthop Sports Phys Ther 2006;36:45-57.

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Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis.

Abstract: Objective-To determine the prevalence of vertebral compression fractures due to osteoporosis in patients with ankylosing spondylitis.

Cited by 157 publications

References 9 publications

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Relationship of bone mineral density with disease activity and functional ability in patients with ankylosing spondylitis: a cross-sectional study

An Electromyographic Analysis of Commercial and Common Abdominal Exercises: Implications for Rehabilitation and Training

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