Prevalence of undiagnosed diabetes and pre-diabetes in chronic periodontitis patients assessed by an HbA1c chairside screening protocol

Mataftsi, Maria

doi:10.26226/morressier.5ac3831c2afeeb00097a4017

Cited by 4 publications

(8 citation statements)

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“…However, another study based on blood analysis found that 17.7% of patients with preDM or DM, including known DM cases, 18 which is nearly equal the value of 18.4% of conspicuous findings in the current study when known and unknown (pre‐)DM were combined. Another recent Greek study examined chairside HbA1c testing of patients with (mostly mild) chronic periodontitis and found that 25% of patients had unknown hyperglycemia 7 . This rate is higher than the current study, but the examination included >80% obese individuals and showed that BMI and waist circumference were associated with HbA1c 7 .…”

Section: Discussioncontrasting

confidence: 68%

“…Another recent Greek study examined chairside HbA1c testing of patients with (mostly mild) chronic periodontitis and found that 25% of patients had unknown hyperglycemia 7 . This rate is higher than the current study, but the examination included >80% obese individuals and showed that BMI and waist circumference were associated with HbA1c 7 . In general, all available results confirm the benefit of DM screening in a dental practice setting.…”

Section: Discussionsupporting

confidence: 64%

“…DM affects the severity of periodontitis and the response to periodontal treatment, which is dependent on glycemic control 6 . Therefore, the concept of screening for unknown DM in patients suffering from periodontal diseases in dental practice was repeatedly mentioned 7–16 . In general, DM screening in dental settings is a promising approach to detect previously unknown (pre‐)DM.…”

Section: Introductionmentioning

confidence: 99%

“…In general, DM screening in dental settings is a promising approach to detect previously unknown (pre‐)DM. Two different procedures are available: invasive blood collection in the dental office for HbA1c measurement 7,15,17–19 and a non‐invasive questionnaire‐based screening followed by the allocation of at‐risk patients to general physicians/diabetologists 8,11,14,20 . Gingival crevicular blood has been considered in the screening of diabetologically conspicuous patients 17 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Schmalz

Wolf

Merle

et al. 2020

Journal of Periodontology

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Background: This practice-based retrospective study evaluated a screening method for diabetes mellitus (DM) in patients with Stage 3 or 4 periodontitis using the FINDRISC questionnaire. Methods: Patients with Stage 3 or 4 periodontitis who received FINDRISC screening in a German private dental practice were recruited. Individuals with positive FINDRISC scores (≥12, FINDRISC+) were referred for diabetological examination. Several general and periodontal findings from the patients' documentation were recorded and analyzed. Results: A total of 179 patients (52.65 ± 11.49 years) were included. In DM screening, 24.6% (n = 44) patients were FINDRISC+, including all patients with currently known DM (21 of 21). Of the remaining FINDRISC+ patients, 82.6% (19 of 23) visited their general practitioner, and 63.2% (12 of 19, 7.6% of total cohort) had an HbA1c ≥5.7%. Accordingly, 75% of the FINDRISC+ patients were diabetologically conspicuous (HbA1c ≥ 5.7%), including those with already known DM. Patients with previously unknown DM showed higher mean age, more missing teeth, a higher periodontitis stage (more Stage 4) and more frequently teeth with suppuration compared with the diabetologically inconspicuous individuals (P <0.01). Conclusion: The FINDRISC questionnaire is appropriate for patients with Stage 3 or 4 periodontitis and can be recommended in dental practice setting.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Schmalz

Wolf

Merle

et al. 2020

Journal of Periodontology

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“…DM has several known complications, including retinopathy, nephropathy, neuropathy, macrovascular abnormalities, prolonged wound healing and PD [ 23 ]. The increasing number of recent studies that have focused on examining the relationship between DM and PD testified to a definite surge in scientific interest [ 24 – 26 ]. Given that certain cytokines and other inflammatory mediators are involved in both diseases, DM and PD appear to have a mutually detrimental effect on each other.…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease in Diabetes Mellitus: A Case–Control Study in Smokers and Non-Smokers

et al. 2020

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Introduction: It is well established that periodontal disease (PD) and diabetes mellitus (DM) can have a detrimental effect on each other's disease course, and that cigarette smoking exacerbates both conditions. However, literature on the periodontal status of smokers with DM is scarce, and the studies conducted to date did not use healthy controls or non-smokers with DM as controls. Consequently, the individual effects of smoking and DM on PD are difficult to untangle and estimate. Methods: A total of 128 participants were recruited to this study and their data analyzed. They were assigned to four groups: smoking

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Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

et al. 2021

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Objective The aim of the study was to investigate the potential interaction between TCF7L2 rs7903146 genotype, which is implicated for type-2 diabetes mellitus genetic susceptibility, HbA1c levels, and the periodontal status of dental patients. Materials and Methods HbA1c levels, clinical periodontal parameters (probing depth, clinical attachment level, bleeding on probing, and plaque index), and several parameters (such as body mass index [BMI], smoking habits, education level, and age) were recorded in 150 patients who fulfilled the criteria for screening for prediabetes/diabetes of the Centers for Disease Control and Prevention. DNA was extracted and the TCF7L2 single nucleotide polymorphism (SNP) rs7903146 was genotyped in all participants. Results Thirty-one patients out of 150 tested were found with unknown hyperglycemia (20.7%). Regarding sex, education, parent with diabetes, normal BMI, smoking, age ≥45 years and prior testing for diabetes, no differences were observed between patients displaying HbA1c < 5.7 and ≥ 5.7% (Pearson’s Chi-square test, p > 0.05). Regarding periodontal parameters and differences between subgroups (HbA1c levels ≥ 5.7 and HbA1c levels < 5.7), statistically significant differences were observed for probing depth (3.20 ± 0.94 vs. 2.81 ± 0.78 mm), clinical attachment level (3.54 ± 1.20 vs. 3.18 ± 1.06 mm) and bleeding on probing (0.62 ± 0.25 vs. 0.50 ± 0.24%) with hyperglycemic patients exhibiting worse periodontal conditions (Mann–Whitney test p < 0.05). The allelic and genotype frequencies for the transcription factor 7-like 2 (TCF7L2) gene, SNPs 7903146 did not exhibit a significant difference between the HbA1c > 5.7 and HbA1c < 5.7 groups and the periodontitis and nonperiodontitis subgroups respectively (Fisher’s exact test >0.05). Statistical Analysis Patient characteristics and their association with prediabetes were tested by Pearson’s Chi-square test (asymptotic, two sided). Differences of periodontal parameters between subgroups were tested with the Mann–Whitney U-test. The associations of allele and genotype frequencies in the patient and control groups were analyzed using the Fisher’s exact test of independence.The significance level was set at the 0.05 for all tests. Conclusion A statistically significant association between TCF7L2 rs7903146 genotype and periodontal condition or HbA1c levels was not observed in contrast to statistically significant differences of clinical parameters of periodontitis in patients with hyperglycemia.

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Prevalence of undiagnosed diabetes and pre-diabetes in chronic periodontitis patients assessed by an HbA1c chairside screening protocol

Cited by 4 publications

References 0 publications

Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Evaluation of a questionnaire‐based diabetes screening concept in German patients with Stage III or IV periodontitis: A practice‐based study

Periodontal Disease in Diabetes Mellitus: A Case–Control Study in Smokers and Non-Smokers

Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

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