Prevalence of undernutrition among adult tuberculosis patients in Ethiopia: A systematic review and meta-analysis

Wondmieneh, Adam; Gedefaw, Getnet; Getie, ፟Addisu; Demis, Asmamaw

doi:10.1016/j.jctube.2020.100211

Cited by 15 publications

(19 citation statements)

References 31 publications

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“…The prevalence of undernutrition recorded by the present study was 51.6% and was a bit less than that reported from the Amhara Region of Ethiopia (57.17%), 19 but similarly in the beginning 50s with that reported from the Adama Town of Ethiopia (53%). 20 The finding of systematic review and meta-analysis on the prevalence of undernutrition in TB patients in Ethiopia also reported a pooled prevalence of 50.8% (95%CI: 43.97-57.63) 21 and the report from Kenya, a neighboring country, as the institution-based study done in Turkana, showed the proportion of TB patients with undernutrition of 50.12% 22 which are also in agreement with the report of the present study. However, lower prevalence (35.8%) of undernutrition was reported from Burkina Faso 23 while a significantly higher prevalence (85%) was reported from central rural India.…”

Section: Discussionsupporting

confidence: 89%

A Cross-sectional Study on the Magnitude of undernutrition in Tuberculosis Patients in the Oromia Region of Ethiopia

Hussien

Ameni

2021

JMDH

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Purpose: To estimate the magnitude of undernutrition in tuberculosis (TB) patients and evaluate its association with selected sociodemographic and clinical characteristics of the patients. Patients and Methods: A health facility-based cross-sectional design was used. Four hundred and fifty pulmonary TB (PTB) patients were recruited between September 2017 and August 2018. Data were collected by structured questionnaire and anthropometric measurements. Data were analyzed using SPSS 20. Descriptive statistics was used for the analysis and expression of the data. Regression model was used to determine the association between undernutrition and selected factors. Results: The magnitude of underweight was 51.6%, (95%CI: 47.15-56.2). Binary logistic regression indicated that previous treatment with anti-TB (crude odds ratio, COR=1.68, 95% CI: 1.08-2.63; p<0.023), duration of illness greater than two months (COR=2.11, 95%CI: 1.26-3.55, p<0.005), positive HIV serum status (COR=3.83, 95%CI: 1.63-9.02, p<0.002) and history of resistance to any anti TB drug (COR=2.76, 95%CI: 1.29-5.91, p<0.009) were associated with underweight. Multiple logistic regression analysis of the association of the aforementioned variables with undernutrition indicated that HIV positivity (adjusted odds ratio, AOR=0.26, 95%CI: 0.104-0.65, p<0.004) and resistance to any anti-TB drug (AOR=0.39, 95%CI: 0.173-0.90, p<0.026) were the associated factors. Conclusion: A significant proportion of TB patients in the Oromia Region were malnourished. Therefore, nutritional counseling and nutritional supplementation are required for the effective treatment of TB patients in the Region.

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Section: Discussionsupporting

confidence: 89%

A Cross-sectional Study on the Magnitude of undernutrition in Tuberculosis Patients in the Oromia Region of Ethiopia

Hussien

Ameni

2021

JMDH

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“…13 Because of this bi-directional relationship, the prevalence of undernutrition in people with TB in low-income settings is high (30-80%). 7,14,15 There are growing calls to address the problem of undernutrition to reduce TB incidence at population level and to improve treatment outcomes among people with active TB. 16 In DRTB, undernutrition is associated with unfavourable treatment outcomes across several cohorts in low-, middle -and high-income countries.…”

Section: Introductionmentioning

confidence: 99%

Undernutrition and Treatment Success in Drug-Resistant Tuberculosis in Uganda

Baluku¹,

Namiiro²,

Nabwana

et al. 2021

IDR

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Background Undernutrition is associated with unfavourable treatment outcomes among people with drug-resistant tuberculosis (DRTB). Factors influencing the treatment outcomes among undernourished people with DRTB are not well characterised. The aim of this study was to determine factors associated with treatment success among undernourished people with DRTB in Uganda. Methods We analysed data from a retrospective cohort of people with DRTB from 16 treatment sites in Uganda. We included participants with a pre-treatment body mass index (BMI) of <18.5 kilograms/meters 2 (kg/m 2 ). Participants were categorised as having mild (BMI of 18.5–17 kg/m 2 ), moderate (BMI of 16.9–16.0 kg/m 2 ) or severe (BMI of <16.0 kg/m 2 ) undernutrition. We performed logistic regression analysis to determine factors associated with treatment success. Results Among 473 people with DRTB, 276 (58.4%) were undernourished (BMI < 18.5 Kg/m 2 ) and were included in the study. Of these, 92 (33.3%) had mild, 69 (25.0%) had moderate and 115 (41.7%) had severe undernutrition. The overall treatment success rate (TSR) for the undernourished was 71.4% (n = 197). Although the TSR was similar among participants with mild (71.7%), moderate (78.3%) and severe (67.0%) undernutrition (p = 0.258), all treatment failure cases (n =6) were among participants with severe undernutrition (p = 0.010). Cigarette smoking (odds ratio (OR) = 0.19, 95% CI 0.07–0.47, p < 0.001), urban residence (OR = 0.31, 95% CI 0.14–0.70, p = 0.005) and moderate (OR = 0.14, 95% CI 0.06–0.35, p < 0.001) and severe anaemia (OR = 0.06, 95% CI 0.01–0.29, p = 0.001) were associated with lower odds of treatment success. Conclusion Most undernourished people with DRTB have severe undernutrition. Smoking and anaemia are modifiable factors which upon appropriate intervention could improve treatment success. The effect of urban residence on the TSR needs to be evaluated further.

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Section: Introductionmentioning

confidence: 99%

“…15 A recent finding of meta-analysis in Ethiopia showed that more than half of TB patients in were undernourished 50.8% which implicates undernutrition of TB patients was noticeably high. 18 In Ethiopia, there are very few reports available on the prevalence, severity and implications of undernutrition in adult patients with TB and no reports in Somali regional state, where the population is geographically, ethnically and culturally different from the population where the available reports were performed. This study aimed to fill this gap by studying the magnitude of undernutrition and associated factors among adult patients with TB in Jigjiga public health facilities.…”

Section: Introduction Backgroundmentioning

confidence: 99%

Undernutrition and Associated Factors Among Adult Tuberculosis Patients in Jigjiga Public Health Facilities, Somali Region, East, Ethiopia

Muse¹,

Osman²,

Ibrahim³

et al. 2021

RRTM

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Background Tuberculosis and undernutrition are the public health concerns of people living in middle and low-income countries. When patient develops TB, undernutrition is not only a risk factor for progression of latent TB infection to active disease, but also intensifies the risk of drug toxicity, relapse and death. Nutritional supplementation in patients with TB is associated with faster sputum conversion, higher cure and treatment completion rates, and body-weight gain. Objective To find out the magnitude of undernutrition and associated factors among adult tuberculosis patients in jigjiga public health facilities. Methods and Materials A facility-based cross-sectional study design was applied. Data were collected using a structured questionnaire while anthropometric measurements were collected in their scale measurements. The data were entered into an Epi-data version 3.1, then were exported and analyzed using SPSS v20. Bivariate logistic regression was done to assess the association between the outcome variable and the independent variables, value <0.25 was considered as a candidate for multivariate logistic regression at 95% CI. In multivariable logistic regression analysis, the level of statistical significance was declared at a p-value less than 0.05. Results The magnitude of undernutrition was 44.3% [95% CI (38.2, 49.7)]. Sex (female) [AOR=1.769, CI=1.035, 3.024], educational status [AOR=3.939, CI=2.285, 6.792] and being Bedridden [AOR=3.718, CI=1.115, 12.394) were predictors of Undernutrition among adult tuberculosis patients. Conclusion The magnitude of undernutrition among adult patients with TB was high in the area. Overall routine appropriate nutrition assessment and support should be given to undernourished patients with TB. The level of education about nutrition should be improved by counseling on a balanced diet to all patients with TB and particularly for female patients. Appropriate nutrition support should be provided to undernourished TB patients, and more focused on those who are bedridden.

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Prevalence of undernutrition among adult tuberculosis patients in Ethiopia: A systematic review and meta-analysis

Cited by 15 publications

References 31 publications

A Cross-sectional Study on the Magnitude of undernutrition in Tuberculosis Patients in the Oromia Region of Ethiopia

A Cross-sectional Study on the Magnitude of undernutrition in Tuberculosis Patients in the Oromia Region of Ethiopia

Undernutrition and Treatment Success in Drug-Resistant Tuberculosis in Uganda

Undernutrition and Associated Factors Among Adult Tuberculosis Patients in Jigjiga Public Health Facilities, Somali Region, East, Ethiopia

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