Prevalence of trypanosomes, salivary gland hypertrophy virus and Wolbachia in wild populations of tsetse flies from West Africa

Ouedraogo, Gisele; Demirbaş-Uzel, Güler; Rayaissé, Jean-Baptiste; Gimonneau, Geoffrey; Traore, Astan C.; Augustinos, Antonios A.; Parker, Andrew G.; Sidibé, Issa; Ouédraogo, Anicet Georges; Traoré, Amadou; Bayala, Bagora; Vreysen, Marc J. B.; Bourtzis, Kostas; Abd-Alla, Adly M. M.

doi:10.1186/s12866-018-1287-4

Cited by 15 publications

(19 citation statements)

References 59 publications

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“…Host-parasite interactions are modulated by a number of factors, including viral infections [35] that may shape the severity and the course of parasitic infections [36]. Parasite vectors host a plethora of organisms that may influence parasite transmission and life cycle [37]. Cutaneous leishmaniasis is highly prevalent in the Amazon region in Brazil [38, 39], which is an area of high transmission of arboviruses.…”

Section: Discussionmentioning

confidence: 99%

Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis

et al. 2019

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Background Leishmania parasites are transmitted to vertebrate hosts by phlebotomine sandflies and, in humans, may cause tegumentary or visceral leishmaniasis. The role of PKR (dsRNA activated kinase) and Toll-like receptor 3 (TLR3) activation in the control of Leishmania infection highlights the importance of the engagement of RNA sensors, which are usually involved in the antiviral cell response, in the fate of parasitism by Leishmania . We tested the hypothesis that Phlebovirus , a subgroup of the Bunyaviridae , transmitted by sandflies, would interfere with Leishmania infection. Methodology/Principal findings We tested two Phlebovirus isolates, Icoaraci and Pacui, from the rodents Nectomys sp. and Oryzomys sp ., respectively, both natural sylvatic reservoir of Leishmania (Leishmania) amazonensis from the Amazon region. Phlebovirus coinfection with L . (L . ) amazonensis in murine macrophages led to increased intracellular growth of L . (L . ) amazonensis . Further studies with Icoaraci coinfection revealed the requirement of the PKR/IFN1 axis on the exacerbation of the parasite infection. L . (L . ) amazonensis and Phlebovirus coinfection potentiated PKR activation and synergistically induced the expression of IFNβ and IL-10. Importantly, in vivo coinfection of C57BL/6 mice corroborated the in vitro data. The exacerbation effect of RNA virus on parasite infection may be specific because coinfection with dengue virus (DENV2) exerted the opposite effect on parasite load. Conclusions Altogether, our data suggest that coinfections with specific RNA viruses shared by vectors or reservoirs of Leishmania may enhance and sustain the activation of host cellular RNA sensors, resulting in aggravation of the parasite infection. The present work highlights new perspectives for the investigation of antiviral pathways as important modulators of protozoan infections.

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Section: Discussionmentioning

confidence: 99%

Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis

et al. 2019

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“…Wolbachia was most prevalent in G. morsitans morsitans , G. morsitans centralis and G. austeni populations. Wolbachia was also found in G. brevipalpis , and, for the first time, in G. pallidipes and G. palpalis gambiensis [ 118 ], but was not detected in G. palpalis palpalis , G. fuscipes fuscipes and G. tachinoides and only at a very low level (<1%) in G. morsitans submorsitans , and G. medicorum [ 118 , 119 ].…”

Section: Main Research Achievements—livestock Pestsmentioning

confidence: 99%

“…The prevalence of SGHV was determined in natural tsetse populations [ 122 ] and its association with other tsetse symbionts and trypanosomes assessed [ 119 ]. The prevalence of the G. pallidipes SGHV (GpSGHV) in G. pallidipes varied between 2% and 100%, depending on the sampling location; however, phylogenetic and gene genealogy analyses revealed low virus diversity [ 122 ].…”

Section: Main Research Achievements—livestock Pestsmentioning

confidence: 99%

“…The prevalence of SGHV in other tsetse species in eastern and southern African countries indicated a lower prevalence in G. morsiatns morsitans from Tanzania (58%) and Zimbabwe (20%) than G. pallidipes collected in Tanzania (88%). The SGHV prevalence was low in G. fuscipes fuscipes (25–40%) from eastern Uganda [ 123 , 124 ] while the lowest prevalence (<2%) was found in species in West Africa such as G. palpalis gambiensis , G. morsitans submorsitans , G. tachinoides and G. medicorum [ 119 ].…”

Section: Main Research Achievements—livestock Pestsmentioning

confidence: 99%

“…In this respect, the prevalence of trypanosome infection was very high in G. tachinoides (61.1%) from Ghana and in G. palpalis gambiensis (43.7%) from Senegal and very low in G. palpalis gambiensis from Mali (6.9%) and Guinea (2.2%). The trypanosome prevalence in the four species from Burkina Faso was 39.6% in G. medicorum , 18.1% in G. morsitans submorsitans , 16.8% in G. tachinoides and 10.5% in G. palpalis gambiensis [ 119 ]. Although coinfection of several trypanosome species was detected, the coinfection of trypanosomes with Wolbachia and SGHV was not found in this study [ 119 ] indicating a possible antagonistic effect or competition for host resources.…”

Section: Main Research Achievements—livestock Pestsmentioning

confidence: 99%

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The Insect Pest Control Laboratory of the Joint FAO/IAEA Programme: Ten Years (2010–2020) of Research and Development, Achievements and Challenges in Support of the Sterile Insect Technique

Vreysen

Abd-Alla

Bourtzis

et al. 2021

Insects

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The Joint FAO/IAEA Centre (formerly called Division) of Nuclear Techniques in Food and Agriculture was established in 1964 and its accompanying laboratories in 1961. One of its subprograms deals with insect pest control, and has the mandate to develop and implement the sterile insect technique (SIT) for selected key insect pests, with the goal of reducing the use of insecticides, reducing animal and crop losses, protecting the environment, facilitating international trade in agricultural commodities and improving human health. Since its inception, the Insect Pest Control Laboratory (IPCL) (formerly named Entomology Unit) has been implementing research in relation to the development of the SIT package for insect pests of crops, livestock and human health. This paper provides a review of research carried out between 2010 and 2020 at the IPCL. Research on plant pests has focused on the development of genetic sexing strains, characterizing and assessing the performance of these strains (e.g., Ceratitis capitata), elucidation of the taxonomic status of several members of the Bactrocera dorsalis and Anastrepha fraterculus complexes, the use of microbiota as probiotics, genomics, supplements to improve the performance of the reared insects, and the development of the SIT package for fruit fly species such as Bactrocera oleae and Drosophila suzukii. Research on livestock pests has focused on colony maintenance and establishment, tsetse symbionts and pathogens, sex separation, morphology, sterile male quality, radiation biology, mating behavior and transportation and release systems. Research with human disease vectors has focused on the development of genetic sexing strains (Anopheles arabiensis, Aedes aegypti and Aedes albopictus), the development of a more cost-effective larvae and adult rearing system, assessing various aspects of radiation biology, characterizing symbionts and pathogens, studying mating behavior and the development of quality control procedures, and handling and release methods. During the review period, 13 coordinated research projects (CRPs) were completed and six are still being implemented. At the end of each CRP, the results were published in a special issue of a peer-reviewed journal. The review concludes with an overview of future challenges, such as the need to adhere to a phased conditional approach for the implementation of operational SIT programs, the need to make the SIT more cost effective, to respond with demand driven research to solve the problems faced by the operational SIT programs and the use of the SIT to address a multitude of exotic species that are being introduced, due to globalization, and established in areas where they could not survive before, due to climate change.

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Interactions among Sodalis, Glossina pallidipes salivary gland hypertrophy virus and trypanosomes in wild Glossina pallidipes

Malulu,

Nyingilili,

Edward

et al. 2023

Int J Trop Insect Sci

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Prevalence of trypanosomes, salivary gland hypertrophy virus and Wolbachia in wild populations of tsetse flies from West Africa

Cited by 15 publications

References 59 publications

Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis

Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis

The Insect Pest Control Laboratory of the Joint FAO/IAEA Programme: Ten Years (2010–2020) of Research and Development, Achievements and Challenges in Support of the Sterile Insect Technique

Interactions among Sodalis, Glossina pallidipes salivary gland hypertrophy virus and trypanosomes in wild Glossina pallidipes

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