Prevalence of Trypanosoma cruzi infection in dogs and small mammals in Nuevo León, Mexico

Galaviz‐Silva, Lucio; Mercado-Hernández, Roberto; Zárate-Ramos, Juan J.; Molina-Garza, Zinnia Judith

doi:10.1016/j.ram.2016.11.006

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…Furthermore, our study is consistent with a previous study which found 0.36% infection prevalence from human residents sampled from 2005–2008 in neighboring Cameron County, Texas [12]. Similarly, the border state of Nuevo Leon, Mexico has a documented history of autochthonous transmission, with a recent study in 2014 identifying a 2% seroprevalence among residents [2] and a 2017 study identifying 14.5% of sylvatic animals seropositive [29].…”

Section: Discussionsupporting

confidence: 91%

Continuing evidence of Chagas disease along the Texas-Mexico border

et al. 2018

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BackgroundChagas disease is a chronic parasitic infection that progresses to dilated cardiomyopathy in 30% of human cases. Public health efforts target diagnosing asymptomatic cases, as therapeutic efficacy diminishes as irreversible tissue damage progresses. Physician diagnosis of Chagas disease cases in the United States is low, partially due to lack of awareness of the potential burden in the United States.Methodology/Principal findingsThe current study tested a patient cohort of 1,196 Starr County, Texas residents using the Hemagen Chagas ELISA Kit as a preliminary screening assay. Samples testing positive using the Hemagen test were subjected to additional confirmatory tests. Two patients (0.17%) without previous Chagas disease diagnosis were identified; both had evidence of acquiring disease in the United States or along the Texas-Mexico border.Conclusions/SignificanceThe Texas-Mexico border is a foci of Chagas disease human cases, with a local disease burden potentially twice the national estimate of Hispanic populations. It is imperative that physicians consider persons with residential histories along the Texas-Mexico border for Chagas disease testing.

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Section: Discussionsupporting

confidence: 91%

Continuing evidence of Chagas disease along the Texas-Mexico border

et al. 2018

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“…Similarly, in northern Mexico, canine T . cruzi infections are also common, with seroprevalence estimates of 4.4% and 9.5% in communities near the USA border [ 45 , 51 ]. Differences in the level of canine infection among studies may relate to differences in the local abundance of infected vectors that feed on dogs and/or may relate to different diagnostic approaches.…”

Section: Discussionmentioning

confidence: 99%

“…Further, travel of infected dogs from endemic regions of the southern USA to non-endemic regions where there is less awareness of Chagas disease is occurring [33], in which case diagnosis may be harder to attain. Similarly, in northern Mexico, canine T. cruzi infections are also common, with seroprevalence estimates of 4.4% and 9.5% in communities near the USA border [45,51]. Differences in the level of canine infection among studies may relate to differences in the local abundance of infected vectors that feed on dogs and/or may relate to different diagnostic approaches.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA

et al. 2021

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Canine Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is increasingly recognized as a health concern for dogs in the USA, and infected dogs may signal geographic regions of risk for human disease. Dogs living in multi-dog kennel environments (kennels with more than one dog) where triatomine vectors are endemic may be at high risk for infection. We monitored a cohort of 64 T. cruzi-infected and uninfected dogs across 10 kennels in Texas, USA, to characterize changes in infection status over one year. We used robust diagnostic criteria in which reactivity on multiple independent platforms was required to be considered positive. Among the 30 dogs enrolled as serologically- and/or PCR-positive, all but one dog showed sustained positive T. cruzi diagnostic results over time. Among the 34 dogs enrolled as serologically- and PCR-negative, 10 new T. cruzi infections were recorded over a 12-month period. The resulting incidence rate for dogs initially enrolled as T. cruzi-negative was 30.7 T. cruzi infections per 100 dogs per year. This study highlights the risk of T. cruzi infection to dogs in kennel environments. To protect both dog and human health, there is an urgent need to develop more integrated vector control methods as well as prophylactic and curative antiparasitic treatment options for T. cruzi infection in dogs.

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“…The most affected countries in South America are Brazil (174,194.22 DALYs), followed by Venezuela (27,037.40 DALYs), and Argentina (23,552.58 DALYs); Uruguay being the least affected (350.72 DALYs) based on the estimations of the Global Burden of Diseases [41]. Concerning Chagas in pets, there were a few studies of seroprevalence of Chagas in dogs in Latin America such as Argentina, Brazil, Chile, Colombia, Ecuador, Mexico, Venezuela but none in Paraguay [42][43][44][45][46][47][48]. Several other mammals are a potential reservoir of Chagas.…”

Section: Discussionmentioning

confidence: 99%

The burden of zoonoses in Paraguay: A systematic review

2021

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Introduction Underestimation of zoonoses is exacerbated in low and middle-income countries due mainly to inequalities with serious consequences in healthcare. This is difficult to gauge and reduce the impact of those diseases. Our study focuses on Paraguay, where the livestock industry is one of the major components of the country’s economy. Therefore, the rationale of this study was to develop a case study in Paraguay to estimate the dual impact of zoonotic diseases on both the human health and animal health sector and thus determine the societal burden of such diseases. Methodology/Principal findings We conducted a systemic review (including a meta-analysis) to assess the burden of zoonoses in Paraguay, including official reports and grey literature of disease incidence and prevalence. We estimated the Disability Adjusted Life Years (DALYs) and Zoonosis Disability Adjusted Life Years (zDALYs) to measure the difference between the current health status and the desired health situation of animals and the Paraguayan population based on 50 zoonotic diseases suggested by the WHO (World Health Organization), OIE (World Organization for Animal Health) and the National Health in Paraguay. The total DALYs represent 19,384 (95% CI: from 15,805 to 29,733), and zDALYs, 62,178 (95% CI: from 48,696 to 77,188). According to the results, the priority pathogens for DALYs are E. coli, Trypanosoma cruzi, Leishmania spp, and Toxoplasma gondii. When we include the additional animal health burden, the most important pathogens are Brucella spp, E. coli, Trypanosoma cruzi, and Fasciola hepatica for zDALYs. Conclusion/Significance This is the first study to integrate DALYs and zDALYs with important clues related to the health status of Paraguay. Through DALYs and zDALYs, our perspective becomes more complete because we consider not only human health but also animal health. This is important for setting priorities in disease control, especially in a society where livestock contribute significantly to the economy and to human well-being.

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Prevalence of Trypanosoma cruzi infection in dogs and small mammals in Nuevo León, Mexico

Cited by 12 publications

References 26 publications

Continuing evidence of Chagas disease along the Texas-Mexico border

Continuing evidence of Chagas disease along the Texas-Mexico border

High incidence of Trypanosoma cruzi infections in dogs directly detected through longitudinal tracking at 10 multi-dog kennels, Texas, USA

The burden of zoonoses in Paraguay: A systematic review

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