Prevalence of trismus in patients with head and neck cancer: A systematic review with meta‐analysis

Watters, Amber L.; Cope, Shane; Keller, Meir N.; Padilla, Mariela; Enciso, Reyes

doi:10.1002/hed.25836

Cited by 58 publications

(37 citation statements)

References 62 publications

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“…Early surgery or radiotherapy can achieve good results, but most patients with head and neck squamous cell carcinoma have exhibited cervical lymph node metastasis or distant metastasis at the first diagnosis. Although surgery plus radiotherapy or chemotherapy can delay the progression of the disease, the patients with stage III/IV do not be improved the long-term survival rate 19 . Therefore, early diagnosis and early treatment are the key to the treatment of OSCC.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC

Luo

Liu

Guo

et al. 2020

Sci Rep

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Studies have found that circRnA in exosomes is associated with oral squamous cell carcinoma (oScc) progression. In this study, we examined the expression of circ_0000199 in circulating exosomes from patients with oScc and its role in the evaluation of relapse and prognosis. Real-time quantitative reverse transcription-polymerase chain reaction was performed to assess circ_0000199 expression in circulating exosomes from 108 patients with OSCC and 50 healthy people. Gain-and loss-functional experiments were performed to assess the role of circ_0000199 on cell proliferation and apoptosis in OSCC cells. Our results showed that the high level of circ_0000199 in circulating exosomes was significantly associated with betel quid chewing, tumor size, lymphatic metastasis, and TNM stage in patients with OSCC. In addition, the patients with high exosomal circ_0000199 had higher tumor recurrence rate and higher mortality rate than the patients with low exosomal circ_0000199. Overexpression of circ_0000199 promoted, while knockdown of circ_0000199 inhibited OSCC cell growth. Bioinformatics analysis predicted that circ_0000199 interacted with miR-145-5p and miR-29b-3p simultaneously, which were involved in multiple tumor-related signaling pathways. in conclusion, upregulation of circ_0000199 in circulating exosomes from patients with OSCC is positively associated with poor survival outcome. Circulating exosomal circ_0000199 can be used as a biomarker and potential therapeutic target for oScc. Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the world, accounting for 3% of malignant tumors 1. Although the treatment of OSCC has made breakthroughs in the past decades, the 5-year mortality rate is still less than 50% 2. Early diagnosis and early treatment are the keys to improve the survival rate of patients with OSCC. Exosomes have phospholipid bilayer membrane with the markers TSG101 and CD63. The size of exosomes ranges from 30 to 100 nm. These vesicles exist in almost all body fluids of the human body, including blood, serum, saliva, cerebrospinal fluid, and urine 3. Exosomes contain various substances, such as proteins, DNA, microRNA (miRNA), circular RNA (circRNA). These molecules can be transported to regulate the signaling pathways of the recipient cells 4. CircRNAs are covalently formed from the ends of a single RNA molecule, without 5′ and 3′ ribonucleotide end, and circRNAs are expressed abundantly, conserved and stably in cells with temporal and spatial specificity 5. CircRNAs can bind to miRNAs to inhibit their functions. Therefore, circRNA is also called miRNA sponge. With the continuous understanding of circRNA, researchers have found that circRNAs are widely involved in the occurrence and development of physiology and disease as well as tumors 6. As a new type of regulatory endogenous RNA, circRNAs are expected to become a tumor diagnostic marker and therapeutic target due to its characteristics such as stability, conservation, and tissue-specific expression 7. For example, circRNA_...

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Section: Discussionmentioning

confidence: 99%

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC

Luo

Liu

Guo

et al. 2020

Sci Rep

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“…Treating HNSCC patients with surgery, instead of CRT, means they avoid the typical complications of RT and CT; xerostomia, osteoradionecrosis, mucositis, sepsis and trismus ( 2 , 4 , 9 , 23 ). A recent study ( 24 ) reported an overall survival rate of 84.9% and a low rate of xerostomia in 442 patients who received intense modulated radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Transoral robotic surgery vs open surgery in head and neck cancer. A systematic review of the literature

Roselló¹,

Albuquerque²,

Roselló-Llabrés³

et al. 2020

Med Oral

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Background TORS has become one of the latest surgical alternatives in the treatment of oropharynx squamous cell carcinomas (OPSCC) and has become increasingly accepted by surgeons as a treatment option. Surgical robots were designed for various purposes, such as allowing remote telesurgery, and eliminating human factors like trembling. The study aimed to compare systematic review of the available literature in order to evaluate the safety and efficacy of Transoral Robotic Surgery (TORS) compared with open surgery. Material and Methods We performed a systematic review of the available literature in order to evaluate the safety and effectiveness of TORS compared with open surgery. We compared TORS and open surgery based on 16 outcomes divided in to 3 groups: intra-operative complications, post-operative complications, and functional and oncologic outcomes. An electronic search of observational studies was carried out using the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Oral Health Group Trials Register, and Scielo. Data analysis was carried out in accordance to Preferred Reporting Items for Systematic Reviews and Metanalysis (PRISMA) and the quality of the studies were evaluated using the Newcastle-Ottawa Scale. No language restrictions were imposed. Results From the 4 studies identified (Newcastle-Ottawa Scale mean score 6.5), 371 patients were revised (186 patients were treated with TORS and 185 with conventional surgery). Overall, TORS, when compared with open surgery, appears to have better functional results (less hospital time, decannulation) and fewer intraoperative and post-operative complications. There is no significant difference when assessing the oncological outcomes (positive margins, survival rate) when comparing both techniques. Conclusions TORS has an overall better functional outcome, and less intraoperative and postoperative complications with no difference in positive margins and survival rate when compared with conventional therapy. Key words: Transoral Robotic Surgery, TORS, open surgery, conventional surgery, head and neck cancer, oral cancer.

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“…The reported prevalence of limitation in mouth opening in patients with oral-maxillofacial malignant tumors ranges from 8% to 62% (13). The patients were a majority male, with an average age from 53.5 to 65.9 years old (14,15). It may be related to the tumor clinical stage, tumor site, treatment(s) used, radiotherapy site, radiotherapy dose, radiotherapy type, follow-up time after treatment and sample variation.…”

Section: The Prevalencementioning

confidence: 99%

The progress of post-treatment restricted mouth opening in oral and maxillofacial malignant tumor patients

Wu¹,

Zhou²,

Zhang³

et al. 2021

Front Oral Maxillofac Med

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Oral and maxillofacial malignant tumor seriously threaten the physical and mental health of patients, especially advanced malignant tumor requiring a comprehensive sequence of surgery-based treatment, resulting in facial deformity, difficulties with chewing, dysphagia and asophia. Among them, trismus (restricted mouth opening) is one of the most common complications after treatment of oral and maxillofacial malignant tumor. In severe cases, they may even suffer from trismus and eating difficulties, finally leading to malnutrition and even cachexia. Therefore, it not only affects the quality of life of the patients and even endangers their lives, but also brings heavy social and economic burden. How to effectively prevent and treat posttreatment trismus is a clinical problem which is easy to be ignored by oral and maxillofacial surgeons and needs to be solved urgently. In recent years, restricted mouth opening (trismus) after post-treatment of oropharyngeal, nasopharyngeal and other head and neck malignant tumors have been widely studied, but restricted mouth opening after comprehensive treatment of oral cancer has been neglected. We therefore conducted a systematic review with 3 aims: (I) to clear the definition of restricted mouth opening and trismus; (II) to identify epidemiology and pathogenesis of restricted mouth opening or trismus; and (III) to summarize the methods of interventions or treatment of oral and maxillofacial malignant tumor patients with restricted mouth opening or trismus.

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Prevalence of trismus in patients with head and neck cancer: A systematic review with meta‐analysis

Cited by 58 publications

References 62 publications

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC

Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC

Transoral robotic surgery vs open surgery in head and neck cancer. A systematic review of the literature

The progress of post-treatment restricted mouth opening in oral and maxillofacial malignant tumor patients

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