Prevalence of transfusion-transmitted infections in multiple blood transfused thalassemia patients: A report from a tertiary care center in North India

Sidhu, Meena; Meenia, Renu; Yasmeen, Irm; Sawhney, Vijay; Dutt, Neeti

doi:10.4103/1755-6783.159849

Cited by 11 publications

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“…However, only few studies have been done on transfusion transmitted syphilis and malaria. 15,16 Those two previous studies also found no positive cases for syphilis and malaria, which is similar to our study finding.…”

Section: Discussionsupporting

confidence: 93%

“…Hepatitis B infection was found in one patient out of 102 patients (0.98%). Gugnani et al 15 found the prevalence of HBV to be 0.79% which was comparable to the present study being 0.98%. Jain et al 17 showed positivity of 1.04% for HBV.The reduction in the prevalence of HBV may be due to hepatitis B vaccination prior blood transfusion.…”

Section: Discussionsupporting

confidence: 90%

“…Our study showed highest occurrence of HCV infection 4/102 (3.90%). The highest prevalence of HCV was also seen in studies like Gugnani et al 14 of 13.4%, Sidhu et al 15 of 13.04%, Manisha et al 16 of 18.2%. Post-transfusion transmission of HCV has still remained a major health concern in multi-transfused patients.…”

Section: Discussionmentioning

confidence: 67%

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Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Lyngdoh

Bagdi

Ghosh³

et al. 2023

Int. J. Hum. Health Sci.

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Background: Blood transfusion is an important treatment modality in the modern health care system; however, transfusion transmitted infections(TTI) could be fatal or life-threatening in some cases.Objective: To determine the occurrence of transfusion transmitted infections among transfusion dependent thalassemia patients and to study the socio-demographic characteristics of the recipients.Methods: This hospital-based descriptive longitudinal studywas conducted between February 2019 and June 2020, on 102 transfusion-dependentthalassaemic patients receiving blood transfusion at Bankura Sammilani Medical College & Hospital, Bankura,West Bengal, India. They were tested for HIV, HBV, HCV, syphilis and malaria by ELISA (Enzyme Linked Immunosorbent Assay) Lisa Scan EM, Merilisa HBsAg, Merilisa HCV, RPR kit and Maleriscan malaria Pf/Pv.Results: Out of 102 patients, 5.90% were positive for TTI. The highest occurrence was found to be of HCV 3.90%. HBV and HIV showed similar occurrence of 0.98% and none came out positive for syphilis or malaria. The highest occurrence of TTI was found among females 66.7%. The average age of the participants was 7.97±3.27years. The average number of blood transfusion received per year was 11.95±2.71units. Majority of the participants belong to low socio- economic group family 62(60.8%). In respect to ethnicity 14.7%were tribal, while 85.3%were non-tribal population.Conclusion: The cause of high prevalence of HCV may be due to donors being asymptomatic in early stages and failure of detection due to window period of infection. More sensitive screening tests should be done for HIV, HBV, and HCV. All donors must be screened by NAT if not possible the patients must be screened for TTI regularly.Thalassemia patients being the most affected, premarital screening for thalassemia should be done.Every patient should be vaccinated with hepatitis B vaccine.International Journal of Human and Health Sciences Vol. 07 No. 02 April’23 Page: 171-175

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

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Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Lyngdoh

Bagdi

Ghosh³

et al. 2023

Int. J. Hum. Health Sci.

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“…HCV was more prevalent (48%) among study participants. HCV infection was also a highly prevalent TTI among multi-transfused patients, as reported in a study (Sidhu et al , 2015).…”

Section: Resultssupporting

confidence: 55%

Effect of flaxseed intervention on iron overload and its complications in thalassemia major patients

Fayyaz,

Qadeer,

Irfan

et al. 2023

NFS

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Purpose Phytochemicals are known for their iron chelation ability with no side effects. Lignans and polyphenols in flaxseed have iron-chelating and antioxidant abilities. Therefore, this study aims to assess the ability of flaxseed to reduce iron overload and minimize its negative health effects. Design/methodology/approach A randomized control trial was conducted. A total of 96 patients were enrolled in this study and randomized into three groups: two intervention groups had 3 or 7 g of whole flaxseed and a control group took a placebo (gram seeds). Interventions were administered for 12 weeks. A hematological profile, ferritin quantification in serum, and liver function tests were performed to evaluate the effects of flaxseed. Findings It was observed that flaxseed with synthetic iron chelators caused a significant reduction in ferritin levels compared with synthetic chelators. The pre-transfusion hemoglobin level was also improved in the intervention group. A significant reduction (p value 0.0003) in ferritin levels among intervention groups indicated that flaxseed reduced the iron overload. It can be concluded that flaxseed reduced iron overload in thalassemia major patients with no side effects and may reduce iron overload solely when taken in adequate quantity. Originality/value Although the study targets a non-specific protein-ferritin for the evaluation of iron-overload, the initial ferritin value and reduction in these levels indicate the efficacy of ferritin for reducing iron overload in thalassemia major patients. Moreover, this is the first study, to the best of the authors’ knowledge, that demonstrates the iron-chelation ability of flaxseed in thalassemia major patients, suggesting the use of flaxseed for iron chelation.

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“…The present study shows a prevalence of 59.3%. The high prevalence has been seen in many studies like the study by Hossein Norouzian et al [11] (2016) showed a prevalence of 11.32%, Khalid Al –N et al [12] (2016) with a prevalence of 41%, Ahmed Kamel M et al [2] (2012) showed a prevalence of 40.5%, Sidhu M et al [13] (2015) with a prevalence of 13.04%, Shrivastava M[14] (2015) showed a prevalence of 18.2%, Jain et al [15] (2012) with a prevalence of 25%, Jaiswal et al [16] (2001) with a prevalence of 21%.…”

Section: Discussionmentioning

confidence: 99%

Menace of Hepatitis C virus among multitransfused thalassemia patients in Balasore district of Odisha state in India

Sinha

Raghuwanshi

Mishra

2019

J Family Med Prim Care

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Context:Hepatitis C virus (HCV) is a potential cause of morbidity and mortality worldwide. It is most commonly transmitted through injecting drug use; the reuse or inadequate sterilization of medical equipment and the transfusion of unscreened blood products. Management of thalassemia requires long-term blood transfusion. Though it improves the overall survival, it carries a definite risk of infection which is expected to be higher in resource limited settings.Aims:To find the percentage of transfusion-transmitted infections (TTIs) in multitransfused patients of thalassemia in Eastern India.Settings and Design:The study was conducted to assess blood safety in rural population in India by measuring the percentage of TTIs including HCV in multitransfused thalassemia patients.Methods and Materials:One hundred and twenty three patients with major beta-thalassemia were enrolled in this study. The blood samples were tested using ELISA technique for all TTIs. HIV fourth generation kits, HbsAg, HCV third generation kits, malaria and syphilis, parbovirus IgM and parbovirus IgG kits, HEV Antigen and IgM antibody were used.Statistical Analysis Used:Proportions and means were calculated for categorical and continuous variables, respectively. Chi-square test was applied and P value of <0.05 was taken as significant.Results:The mean age of patients was 9.5 years ± 5.2 years. Among various TTIs, Hepatitis C and HIV was prevalent among 59.3% and 4.1% of the study participants, respectively.Conclusions:The causes of high prevalence of HCV may be due to donors being usually asymptomatic in early stages, despite being screened for HCV possibly due to missing early window period infections. The screening methodology of TTIs particularly HCV at the district and village level and consequent increased prevalence of HCV in multitransfused rustic population of India shows the extent of blood safety.

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Prevalence of transfusion-transmitted infections in multiple blood transfused thalassemia patients: A report from a tertiary care center in North India

Cited by 11 publications

References 0 publications

Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Effect of flaxseed intervention on iron overload and its complications in thalassemia major patients

Menace of Hepatitis C virus among multitransfused thalassemia patients in Balasore district of Odisha state in India

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