Prevalence of the metabolic syndrome in rheumatoid arthritis

Özmen, Mustafa; Yersal, Özlem; Öztürk, Serpil; Soysal, Dilek; Köseeoğlu, Mehmet Hicri

doi:10.5152/eurjrheum.2014.001

Cited by 20 publications

(12 citation statements)

References 19 publications

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“…Similar to the present study, Karvounaris et al 10 conducted a study of 200 patients with RA to evaluate MetS and reported the prevalence of MetS among the patients to be 44%. In contrast to that and the current study, Özmen et al 11 and Mok et al 12 reported MetS prevalence of 28.8% and 20% in patients with RA. A difference fact was observed.…”

Section: Discussioncontrasting

confidence: 99%

Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis

Kesikburun¹,

Çakçı²

2018

Ankara Medical Journal

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Objectives: To evaluate and compare the prevalence of insulin resistance and metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to determine the relationship of MetS with disease-activities and the factors associated with MetS. Materials and Methods:The cross-sectional study included a total of 174 patients with RA and AS. MetS was defined according to the International Diabetes Federation (IDF) criteria. Insulin resistance was assessed with the Homeostasis Model Assessment (HOMA) Index. The Disease Activity Score including 28 joints (DAS28) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were used to measure disease activity. Functional status was evaluated using the Health Assessment Questionnaire (HAQ) and the Bath Ankylosing Spondylitis Functional Index (BASFI). Logistic regression analysis was applied to identify predictors of metabolic syndrome. Results: The prevalence of MetS was significantly higher in patients with RA (47%) than in patients with AS (24.56%) (p=0.005). The prevalence of insulin resistance was significantly higher in patients with RA (34.18%) than in patients with AS (17.54%)(p=0.031). No significance difference was found in the disease activity score between RA and AS patients with metabolic syndrome and without metabolic syndrome (p=0.580 and p=0.158, respectively). The number of patients with a higher BASDAI score was greater in AS patients with MetS. Age and body mass index were determined to be predictors for MetS (p=0.015 and p<0.001, respectively). Conclusion: Higher rates of MetS and insulin resistance were seen in RA patients compared to the patients with AS. Better control of the MetS components and disease activity may help to decrease the prevalence of MetS in rheumatic disease. Key words: Metabolic syndrome, rheumatoid arthritis, ankylosing spondylitis, disease activity

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Section: Discussioncontrasting

confidence: 99%

Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis

Kesikburun¹,

Çakçı²

2018

Ankara Medical Journal

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“…In some studies, it has been shown that CVD rate is increased in RA (4,6,27,28). However, the evaluation of risk factors for CVD in this group of patients was restricted.…”

Section: Discussionmentioning

confidence: 99%

Body composition in patients with rheumatoid arthritis is not different than healthy subjects

et al. 2014

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“…Evidence regarding the impact of MetS on RA is mixed. Several studies that assessed patients with RA with MetS showed this population is more likely to have higher Health Assessment Questionnaire (HAQ) scores than patients without MetS; however, other studies have not shown a significant difference 37‐41 . Two large‐scale studies that included 100 patients showed that MetS was associated with high systemic inflammatory markers, disease activity, and disability scores compared with patients with RA but without MetS 42,43 .…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis on prevalence of metabolic syndrome in psoriatic arthritis, rheumatoid arthritis and psoriasis

et al. 2021

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Background Psoriatic arthritis (PsA), rheumatoid arthritis (RA) and psoriasis (PsO) are associated with systemic inflammation and increased cardiovascular mortality and morbidity. Metabolic syndrome (MetS) is associated with systemic inflammation, and conditions associated with MetS, such as obesity, are associated with difficulty in attaining minimal disease activity (MDA) in individuals with inflammatory arthritis. This systematic review aims to determine whether there is an increased prevalence of MetS in PsA populations compared with PsO and RA populations. Methods A systematic review was conducted to assess the prevalence of MetS in PsA, PsO, and RA populations following Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines. The quality of the studies reviewed was assessed using the Joanna Briggs Institute Checklist for Prevalence Studies. Results The pooled prevalence of MetS in PsA populations was 0.46 ± 0.06 (95% CI 0.40‐0.51). In comparison, the prevalence of MetS in PsO and RA populations was 0.34 ± 0.03 (95% CI 0.32‐0.37) and 0.31 ± 0.04 (95% CI 0.27‐0.35), respectively. Patients with PsA were 1.62 ± 0.036 (95% CI 1.50‐1.74) and 1.66 ± 0.038 (95% CI 1.54‐1.79) times more likely to have MetS compared with PsO and RA populations. Conclusion The prevalence of MetS is significantly increased in PsA populations compared with PsO and RA populations. Further studies should be performed using a standardized definition of MetS in PsA, RA, and PsO populations to determine whether addressing the metabolic components in MetS offers any therapeutic benefits and in terms of attaining MDA and improving cardiovascular health.

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Prevalence of the metabolic syndrome in rheumatoid arthritis

Abstract: The evaluation of patients with RA for MetS, which is a multidimensional risk factor of CVD, may be beneficial.

Cited by 20 publications

References 19 publications

Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis

Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis

Body composition in patients with rheumatoid arthritis is not different than healthy subjects

Systematic review and meta‐analysis on prevalence of metabolic syndrome in psoriatic arthritis, rheumatoid arthritis and psoriasis

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