Prevalence of the Brugada-Type Electrocardiogram and Incidence of Brugada Syndrome in Patients With Sick Sinus Syndrome

Hayashi, Hidemori; Sumiyoshi, Masataka; Yasuda, Masayuki; Komatsu, Kaoru; Sekita, Gaku; Kawano, Yasunobu; Tokano, Takashi; Nakazato, Yuji; Daida, Hiroyuki

doi:10.1253/circj.cj-09-0455

Cited by 12 publications

(8 citation statements)

References 36 publications

(45 reference statements)

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“…Hayashi et al examined patients with an indication for a pacemaker for SSS and found that a Brugada‐type ECG was found in 2.87%, including 0.82% with type 1 13. In that study, they presented 4 patients with a type 1 ECG and 1 was a female.…”

Section: Discussionmentioning

confidence: 95%

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome

Aizawa

Fujisawa

Katsumata

et al. 2018

JAHA

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BackgroundBrugada syndrome (BS) is known to be 9 times more prevalent in males than females. However, little is known about the development of sick sinus syndrome in female members with familial BS.Methods and ResultsFamilial BS patients and family members, both from our institutions and collaborating sites that specialize in clinical care of BS, participated in this study. We collected information on their clinical and genetic background, along with the inheritance patterns of BS. Detailed information on each case with familial BS is described. A total of 7 families, including 25 BS patients (12 females and 13 males), were included. Seven were probands and 18 were family members. Ten out of the 12 female patients and none of the 13 male patients developed sick sinus syndrome. Sudden death or spontaneous ventricular fibrillation occurred in 7 out of 13 male patients and 2 out of 12 female patients.ConclusionsFamilial BS existed in which female patients developed sick sinus syndrome but male patients did not. Some of those female patients with sick sinus syndrome had unrecognized BS. Information should be collected not only regarding a family history of sudden death or BS, but also whether a pacemaker was implanted in female members.

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Section: Discussionmentioning

confidence: 95%

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome

Aizawa

Fujisawa

Katsumata

et al. 2018

JAHA

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“…[26][27][28] In children, the prevalence of SND seems to be higher (6.7%-9.0%) compared to the adult patients. 26,29,30 Conversely, we studied the prevalence of Brugada-type ECG in 487 consecutive patients who had been diagnosed as having SSS and were implanted with a cardiac pacemaker, 31 and our analyses demonstrated that the prevalence of Brugada-type ECG in this SSS group was higher (0.82%) compared to the general population (0.005%-0.28%). [12][13][14][15][16][17][18][19][20] Thus, SND seems to be not uncommon among individuals with BrS.…”

Section: Brugada Synd Rome Associated With Sinus Node Dysfunctionmentioning

confidence: 99%

Brugada syndrome and sinus node dysfunction

Hayashi

Sumiyoshi

Nakazato

et al. 2018

Journal of Arrhythmia

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Brugada syndrome (BrS) is a well‐known catastrophic disease first reported in 1992 by the Brugada brothers. Ventricular fibrillation (VF) is an essential arrhythmia in BrS. An association between BrS and atrial tachyarrhythmias is not uncommon. However, sinus node dysfunction (SND) associated with BrS has not been well discussed. In this review, we focus on the association between BrS and SND. Based on previous reports describing clinical, epidemiological, and genetic evidence, SND is not a rare concomitant disorder in BrS. BrS may be a multiple conduction or arrhythmogenic disorder including not only the His‐Purkinje system and right ventricle, but also the sinus node and atrium, derived from ion channel mutations.

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“…In a retrospective analysis, among 487 patients diagnosed with SND, BS ECG phenotype was found in 14 patients (2.87%) including 4 (0.82%) with type 1 and 10 (2.05%) with type 2. During follow-up, 2 out of the 4 patients with type 1 ECG pattern experienced a VT/VF episode [21]. Spontaneous augmentation of ST-segment elevation in daily life has been described along with an increase in vagal activity in BS patients [22].…”

Section: Discussionmentioning

confidence: 99%