Sinus node disease in subjects with type 1 ECG pattern of Brugada syndrome

Letsas, Κonstantinos P.; Korantzopoulos, Panagiotis; Efremidis, Michael; Weber, Reinhold; Lioni, Louiza; Bakosis, George; Vassilikos, Vassilios; Deftereos, Spyridon; Sideris, Antonios; Arentz, Thomas

doi:10.1016/j.jjcc.2012.12.006

Cited by 18 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In that study, they presented 4 patients with a type 1 ECG and 1 was a female. On the contrary, Letsas et al examined spontaneous or drug‐induced BS patients, and SSS was found in 6 symptomatic subjects (8.8%) 14. In that study, 3 out of the 6 patients with BS and SSS were females but 2 patients with a type 1 BS ECG were female.…”

Section: Discussionmentioning

confidence: 91%

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome

Aizawa

Fujisawa

Katsumata

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundBrugada syndrome (BS) is known to be 9 times more prevalent in males than females. However, little is known about the development of sick sinus syndrome in female members with familial BS.Methods and ResultsFamilial BS patients and family members, both from our institutions and collaborating sites that specialize in clinical care of BS, participated in this study. We collected information on their clinical and genetic background, along with the inheritance patterns of BS. Detailed information on each case with familial BS is described. A total of 7 families, including 25 BS patients (12 females and 13 males), were included. Seven were probands and 18 were family members. Ten out of the 12 female patients and none of the 13 male patients developed sick sinus syndrome. Sudden death or spontaneous ventricular fibrillation occurred in 7 out of 13 male patients and 2 out of 12 female patients.ConclusionsFamilial BS existed in which female patients developed sick sinus syndrome but male patients did not. Some of those female patients with sick sinus syndrome had unrecognized BS. Information should be collected not only regarding a family history of sudden death or BS, but also whether a pacemaker was implanted in female members.

show abstract

Section: Discussionmentioning

confidence: 91%

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome

Aizawa

Fujisawa

Katsumata

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…Furthermore, S‐ICD lead damage has been described as a cause of device malfunction . Although BrS patients are young and do not usually require pacing, a small percentage might have sinus node dysfunction and will need an atrial and a ventricular lead . Additionally, a minority of BrS patients (∼4%) may experience monomorphic VT which can effectively respond in antitachycardia pacing .…”

Section: Management Of Asymptomatic Individuals With Brugada Ecg Patternmentioning

confidence: 99%

“…S-ICD offers a lot of benefits reducing major complications such as pneumothorax, infections, lead malfunctions, and inappropriate therapies 102. With respect to BrS, these patients present the highest rate of screening failure and a lower number of appropriate S-ICD vectors as compared to Although BrS patients are young and do not usually require pacing, a small percentage might have sinus node dysfunction and will need an atrial and a ventricular lead 101,106. Additionally, a minority of BrS patients (∼4%) may experience monomorphic VT which can effectively respond in antitachycardia pacing 107.…”

mentioning

confidence: 99%

Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review

Letsas

Asvestas

Baranchuk

et al. 2017

Pacing Clinical Electrophis

Self Cite

View full text Add to dashboard Cite

Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter‐defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow‐up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases.

show abstract

“…47,48 Not surprisingly, it can be present in BS patients. The underlying mechanism is not clear; a more expressive form of the disease might be involved.…”

Section: Sinus Node Dysfunctionmentioning

confidence: 99%

Brugada Syndrome: Defining the Risk in Asymptomatic Patients

Sieira¹,

Brugada²

2016

Arrhythmia &Amp; Electrophysiology Review

View full text Add to dashboard Cite

Since the first description of the Brugada syndrome (BS) in 1992, scientific progress in the understanding of this disease has been enormous; at the same time more and more individuals with the disease have been diagnosed. The profile of patients with BS has changed with more asymptomatic individuals and less expressive clinical features. Asymptomatic BS individuals are at lower arrhythmic risk than those presenting with syncope or sudden cardiac death (SCD). The event incidence rate is around 0.5 % per year; this figure is relevant due to the fact that individuals have a long life expectancy and are otherwise healthy. As a result of the risk of SCD, risk stratification is of utmost importance. As the implantation of a cardioverter defibrillator is the main treatment for those patients at higher risk, benefits and long-term potential risks have to be adequately considered. Some risk factors, such as spontaneous type 1 electrocardiogram (ECG) pattern, are widely accepted, whilst for others contradictory data are present. Furthermore, novel risk factors are now available that might help in the management of BS. The presence of a spontaneous type 1 ECG pattern, history of sinus node dysfunction and inducible ventricular arrhythmias during programmed electrical stimulation of the heart allow us to risk stratify these patients.

show abstract

Sinus node disease in subjects with type 1 ECG pattern of Brugada syndrome

Abstract: SND is not an uncommon finding in subjects with type 1 ECG pattern of BS. The occurrence of SND in relatively young patients may deserve meticulous investigation including sodium channel blocking test.

Cited by 18 publications

References 32 publications

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome

Sex‐Dependent Phenotypic Variability of an SCN5A Mutation: Brugada Syndrome and Sick Sinus Syndrome

Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review

Brugada Syndrome: Defining the Risk in Asymptomatic Patients

Contact Info

Product

Resources

About