Prevalence of serological markers for celiac disease (IgA and IgG class antigliadin antibodies and IgA class antiendomysium antibodies) in patients with autoimmune rheumatologic diseases in Belo Horizonte, MG, Brazil

Koehne, Victor de Barros; Bahia, Mirleide Chaar; Lanna, Cristina Costa Duarte; Pinto, Manuel R.; Bambirra, Eduardo Alves; Cunha, Aloísio Sales da

doi:10.1590/s0004-28032010000300008

Cited by 24 publications

(14 citation statements)

References 45 publications

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“…The consequences of undiagnosed CD are not well described. Studies have shown that patients with CD have an increased risk of other autoimmune diseases and gastrointestinal cancer [ 26 , 27 , 28 ]. One study found a fourfold increased mortality in persons with untreated and undiagnosed CD [ 29 ], whereas others reported mortality rates to be relatively similar to those observed in the background population [ 2 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Screening for celiac disease in Danish adults

Horwitz

Skaaby

Kårhus

et al. 2015

Scandinavian Journal of Gastroenterology

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Objective. The prevalence of celiac disease (CD) as recorded in the Danish National Patient Registry is ∼50/100,000 persons. This is much lower than the reported prevalence of CD in other Nordic countries and underdiagnosis is suspected. Our aim was to estimate the prevalence of CD in a population-based study of Danish adults. Methods. A total of 2297 adults aged 24–76 years living in the southwestern part of Copenhagen were screened for CD by immunoglobulin (Ig)A and IgG antibodies to transglutaminases and deamidated gliadin. IgA/IgG-positive participants were invited to a clinical evaluation, including biopsies, by a gastroenterologist. Results. Of the invited 56 participants, 40 underwent a full clinical evaluation and 8 persons were diagnosed with CD; 2 of the 16 persons, who did not complete the clinical evaluation, were considered by experts to have probable CD. None of the above 56 participants had a known history of CD or a recorded diagnosis of CD in National Patient Registry. By combining cases of biopsy-proven CD (n = 8), probable CD (n = 2), and registry-recorded CD (n = 1), the prevalence of CD was estimated to be 479/100,000 (11/2297) persons (95% CI: 197–761). Conclusion. In this general adult population, the prevalence of CD as estimated by screening and clinical evaluation was 10 times higher than the registry-based prevalence of CD. Of 11 participants diagnosed with CD in our screening study, 10 were unaware of the diagnosis prior to the study. Thus, our study suggests that CD is markedly underdiagnosed in Danish adults.

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Section: Discussionmentioning

confidence: 99%

Screening for celiac disease in Danish adults

Horwitz

Skaaby

Kårhus

et al. 2015

Scandinavian Journal of Gastroenterology

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“…Paimela et al [47] reported that AGA (IgA and/or IgG) was positive in 37% of patients with rheumatoid arthritis and in 12% of healthy controls. However, in a recent study on 190 patients with some autoimmune rheumatologic diseases (systemic lupus erythematosus, rheumatoid arthritis, juvenile rheumatoid arthritis, and spondyloarthrophathies), antigliadin IgA or IgG antibodies were found to be positive only in 4 and 3 patients, respectively [48]. The pronounced difference between the results of these studies may be explained by the difference in disease groups and variations in autoimmunity mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Polyautoimmunity among Patients with Celiac Disease: A Cross-Sectional Survey

et al. 2015

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Aim: To define the prevalence of polyautoimmunity (PAI) among celiac disease (CD) patients and to compare clinical and laboratory features of CD patients with or without PAI in order to determine the risk factors for PAI in CD. Material and Method: Patients diagnosed with CD in our clinic between 2007 and 2014 with at least 1 year of follow-up were retrospectively evaluated. Totally 145 patients were included in the study. Information on patient demographics and laboratory data were obtained from patient records. The study participants were divided into 2 groups. Group 1 was the CD-alone group consisting of patients without any other autoimmune diseases (AIDs), while group 2 was the PAI group consisting of patients with accompanying one or more AIDs. Results: The mean age of 145 CD patients (106 female and 39 male) included in the study was 37.2 ± 12.3 years. Of the 145 patients included, 48 (33.1%) were in the PAI group. When two groups were compared with each other in terms of the demographic features and laboratory data, the following were identified as risk factors for PAI: female gender, family history for AIDs, antigliadin IgG positivity, vitamin D deficiency, antinuclear antibody positivity ≥1/80 titer and having any musculoskeletal disease. Conclusion: To the best of our knowledge, this is one of the largest studies in the literature on CD patients for the PAI prevalence and related risk factors. Identification of the risk factors in early stages is important to explore PAI among CD patients. Larger, prospective studies are warranted about the risk factors and autoimmune characteristics of CD.

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“…A total of 27 studies comprising 28 articles were included in the model [ 50 , 52 , 54 , 55 , 66 , 69 , 71 – 74 , 78 , 80 , 82 , 83 , 85 – 87 , 89 , 90 , 94 , 97 , 100 , 114 , 116 – 118 , 121 , 122 ]. The work of Remes-troche, et al .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 49 studies were included in this model [ 50 , 52 – 55 , 58 – 73 , 75 , 77 , 79 – 81 , 83 , 85 , 88 , 90 , 94 , 96 , 99 – 102 , 104 , 107 , 109 – 113 , 116 – 121 ]. Within three studies obtained from the systematic review, the population was divided into subpopulations.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression

et al. 2015

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BackgroundCeliac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis.Methods and FindingsThis was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46% and 0.64%. The prevalence of CD in first-degree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies).ConclusionsAlthough CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.

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Prevalence of serological markers for celiac disease (IgA and IgG class antigliadin antibodies and IgA class antiendomysium antibodies) in patients with autoimmune rheumatologic diseases in Belo Horizonte, MG, Brazil

Cited by 24 publications

References 45 publications

Screening for celiac disease in Danish adults

Screening for celiac disease in Danish adults

Risk Factors for Polyautoimmunity among Patients with Celiac Disease: A Cross-Sectional Survey

Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression

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