Prevalence of Sensitization toBlomia tropicalisamong Young Adults in a Temperate Climate

Juliá-Serdà, Gabriel; Cabrera-Navarro, Pedro; Acosta-Fernández, Orlando; Martín-Pérez, P.; Bello, Miguel Ángel García; Antó-Boqué, Josep

doi:10.3109/02770903.2012.672611

Cited by 21 publications

(19 citation statements)

References 25 publications

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“…Analyzing subjects with allergic rhinitis and/or asthma with SPT to HDM and storage mites (SM) –including Blomia tropicalis- 82% had SPT positivity to HDM and% to SM, but only 1.5% of the patients were sensitized to SM without HDM sensitization, as judged by SPT, and 14% according to specific IgE [29]. In a non-selected population of adults in Canary Islands, Spain, SPT positivity for Blomia was as high as 37.2% among those patients with rhinitis symptoms (95% CI 28.1-47.6%) and even 50% among those with asthma (95% CI 26.8-73.2%) [28]. …”

Section: Discussionmentioning

confidence: 99%

Allergen sensitization linked to climate and age, not to intermittent‐persistent rhinitis in a cross‐sectional cohort study in the (sub)tropics

Larenas‐Linnemann

Michels

Dinger

et al. 2014

Clinical & Translational All

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BackgroundAllergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate to AR phenotypes or age.MethodsIn a national, cross-sectional study AR patients (2-70 y) seen by allergists underwent blinded skin prick testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes.Results628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Patients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermittent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p < 0.05) and grass pollen sensitization (p < 0.01). HDM sensitization was more frequent in children (0-11 y) and adolescents (12-17 y) (subtropical region: p < 0.0005; tropical region p < 0.05), but pollen sensitization becomes more important in the adult patients visiting allergists (Adults vs children + adolescents for tree pollen: p < 0.0001, weeds: p < 0.0005).ConclusionsIn a country with (sub)tropical climate zones SPT sensitization patterns varied according to climatological zones; they were different from those found in Europe, HDM sensitization far outweighing pollen allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen sensitization was related to SAR, but no relation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens –some region specific- cover the majority of sensitizations in (sub)tropical climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries.

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Section: Discussionmentioning

confidence: 99%

Allergen sensitization linked to climate and age, not to intermittent‐persistent rhinitis in a cross‐sectional cohort study in the (sub)tropics

Larenas‐Linnemann

Michels

Dinger

et al. 2014

Clinical & Translational All

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“…All of these factors influencing the allergen prevalence could in turn have a direct effect on the allergenicity of mites within different environments and/or periods of the year. Of note, an increase in B. tropicalis allergy has been observed over the last decades, changing immunoglobulin E (IgE) reactivities worldwide [3,6,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, this globule-shaped mite was especially found in storage facilities for grains and as contamination of processed food made from grains [1]. Nowadays it is well accepted that B. tropicalis also constitutes a very important house dust mite species, especially, but not exclusively, in the tropical and subtropical regions of the world [2,3,4,5]. In addition to allergen polymorphisms, some authors have claimed seasonal dynamic patterns of mite species, allergen densities within them, and different specific breeding sites [6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules

Silva¹,

Asam

Lackner

et al. 2017

Int Arch Allergy Immunol

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Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees. Here, we provide an overview of recent developments concerning the identification and production of recombinant Blomia allergens, as well as their structural and immunological characterization. Although considerable progress has been achieved, detailed molecule-based studies are still needed to better define the clinical relevance of Blomia allergens. Thus, the establishment of a well-standardized and fully characterized panel of allergens remains a challenge for the development of better diagnosis and therapy of allergic diseases induced by B. tropicalis.

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“…In most parts of the world, DP and DF account for over 70–80% of sensitisations due to mites 7. However, during the last decade, sensitisation to BT has been increasingly reported in intertropical and temperate zones 10 19. The prevalence of the sensitisation to mites to different species of mites among atopic patients varies substantially across regions around the world.…”

Section: Discussionmentioning

confidence: 99%

Sensitisation to mites in a group of patients with asthma in Yaounde, Cameroon: a cross-sectional study

2014

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ObjectivesSensitisation of asthmatic patients to mites in sub-Saharan Africa has been less described. The aim of this study was to assess the prevalence and determinants of sensitisation to mites in asthmatic adolescents and adults in Yaounde, Cameroon.DesignThis was a cross-sectional study. Logistic regression models were employed to investigate the determinants of sensitisation to mites.SettingThis study was carried out at the Jamot Hospital and CEDIMER private centre, in Yaounde, capital city of Cameroon.ParticipantsAll asthmatic patients received in consultations from January 2012 to June 2013 and in whom prick-skin tests for perennial aeroallergens were performed were included.Outcome measuresPrevalence of sensitisation to mites and associated factors.ResultsIn total, 201 patients (132 being women, 65.7%), with a median age of 36 (25th–75th centiles: 20–54) years were included, with 135 (67.2%) having a positive skin test for mites. Sensitisation to Dermatophagoïdes pteronyssinus, Dermatophagoides farinae and Blomia tropicalis was found in 53.2%, 49.8% and 47.8% of the patients, respectively. Intermittent rhinitis (16.3% vs 7.6%) and persistent rhinitis (43.0% vs 22.7%) were more frequent in sensitised patients than in the non-sensitised ones (p<0.010). Independent allergological determinants of sensitisation to mites were sensitisation to Alternaria alternata (adjusted OR 14.98 (95% CIs 1.96 to 114.4)) and sensitisation to Blattella germanica (3.48 (1.34 to 9.00)).ConclusionsSensitisation to mites was found in about two-thirds of asthmatic patients in this setting, with a frequent multiple sensitisations to A alternata and Blattella germanica. Systematically investigating asthmatic patients for mites' sensitisation and determinants will help optimising the care in this setting by combining the aetiological treatment for the allergy with symptomatic treatment for asthma, in order to modify the natural course of the disease.

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Prevalence of Sensitization toBlomia tropicalisamong Young Adults in a Temperate Climate

Abstract: The prevalence of sensitization to BT among young adults in the Canary Islands is high, and it displays a close relationship with allergic respiratory diseases and dermatitis.

Cited by 21 publications

References 25 publications

Allergen sensitization linked to climate and age, not to intermittent‐persistent rhinitis in a cross‐sectional cohort study in the (sub)tropics

Allergen sensitization linked to climate and age, not to intermittent‐persistent rhinitis in a cross‐sectional cohort study in the (sub)tropics

Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules

Sensitisation to mites in a group of patients with asthma in Yaounde, Cameroon: a cross-sectional study

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