Prevalence of sarcopenia in older <scp>B</scp>razilians: A systematic review and meta‐analysis

Diz, Juliano Bergamaschine Mata; Leopoldino, Amanda Aparecida Oliveira; Moreira, Bruno de Souza; Henschke, Nicholas; Dias, Rosângela Corrêa; Pereira, Leani Souza Máximo; Oliveira, Vinícius Cunha

doi:10.1111/ggi.12720

Cited by 95 publications

(92 citation statements)

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“…Muscle function, a key indicator of sarcopaenia using the EWGSOP recommendation,5 was not assessed in our study. However, a recent meta‐analysis in a Brazilian population did not find significant difference for the prevalence of sarcopaenia using muscle mass and function criteria (EWGSOP) or muscle mass alone (Baumgartner's criteria) 40. The low number of patients and the missing data, though taken into account in the statistic models, could be insufficient to exclude an effect of TCZ on cardiometabolic profile.…”

Section: Discussionmentioning

confidence: 95%

Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis

Tournadre

Pereira

Dutheil

et al. 2017

J cachexia sarcopenia muscle

141

127

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BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti‐interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA.MethodsTwenty‐one active RA patients treated with TCZ were included in a 1 year open follow‐up study. Waist circumference, body mass index, blood pressure, lipid profile, fasting glucose, insulin, serum levels of adipokines and pancreatic/gastrointestinal hormones, and body composition (dual‐energy X‐ray absorptiometry) were measured at baseline and 6 and 12 months of treatment. At baseline, RA patients were compared with 21 non‐RA controls matched for age, sex, body mass index, and metabolic syndrome.ResultsCompared with controls, body composition was altered in RA with a decrease in total and appendicular lean mass, whereas fat composition was not modified. Among RA patients, 28.6% had a skeletal muscle mass index below the cut‐off point for sarcopaenia (4.8% of controls). After 1 year of treatment with TCZ, there was a significant weight gain without changes for fat mass. In contrast, an increase in lean mass was observed with a significant gain in appendicular lean mass and skeletal muscle mass index between 6 and 12 months. Distribution of the fat was modified with a decrease in trunk/peripheral fat ratio and an increase in subcutaneous adipose tissue. No changes for waist circumference, blood pressure, fasting glucose, and atherogenic index were observed.ConclusionsDespite weight gain during treatment with TCZ, no increase in fat but a modification in fat distribution was observed. In contrast, muscle gain suggests that blocking IL‐6 might be efficient in treating sarcopaenia associated with RA.

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Section: Discussionmentioning

confidence: 95%

Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis

Tournadre

Pereira

Dutheil

et al. 2017

J cachexia sarcopenia muscle

141

127

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“…However, the criteria identified the absence of sarcopenia in a similar manner. A recent meta-analysis 3 with Brazilians of age reported that sarcopenia prevalence did not change with the use of diagnostic criteria recommended by EWGSOP (16%) or by measuring only muscle mass with DEXA and Baumgartner's criteria (17%). In this context, exceptionally in an older population very debilitated and unable to perform functional assessments, analysis of muscle mass as the sole criterion for generically identifying sarcopenic individuals may be too specific.…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that, after arriving in their 50s, there is annual loss of 1% in muscle mass, 2% in walking speed and from 1.9 to 5.0% in handgrip strength. This reduction in muscle mass affects about 20% of women 3 . However, although it is currently quite a studied topic, there is still no widely accepted consensus in the literature regarding its diagnostic criteria 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…However, the several possibilities available for determining and classifying sarcopenia hinder the understanding and identification of the signs and symptoms involved in this geriatric syndrome 4 . Currently, the study of diagnostic criteria for sarcopenia has become more discussed 3 , opposing the identification of this syndrome that uses exclusively measurement of muscle mass to the possibility of considering physicalfunctional assessments for identification of the older population with sarcopenia, as well as determining the severity of the case. Although questioned, the use of only muscle mass to diagnose sarcopenia allows for functional evaluations of impaired older population settings and makes it possible to screen people of age that may have a higher risk of progressing into moderate and severe sarcopenia accompanied by functional limitations.…”

Section: Introductionmentioning

confidence: 99%

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Concordância de diferentes critérios de sarcopenia em idosas comunitárias

et al. 2018

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| The frequency and concordance between different sarcopenia criteria was assessed in community women of age. This is a cross-sectional study with 64 women of age, in which muscle mass was determined by bioelectrical impedance analysis (BIA) and skeletal muscle index calculation, muscle strength was determined with a handgrip strength dynamometer, functional capacity was determined with the tests Timed Up and Go (TUG) RESUMEN | Se determinó la frecuencia y la concordancia entre distintos criterios de sarcopenia en ancianas comunitarias.Se trata de un estudio transversal con 64 ancianas, en el cual se determinó la masa muscular por el análisis de impedancia bioeléctrica (BIA) y cálculo del índice muscular esquelético, la fuerza muscular fue determinada por el dinamómetro de prensión palmar, la capacidad funcional por las pruebas Timed Up and Go (TUG) y Sit to Stand test (STS). Los ancianosfueron clasificados en no sarcopénicos, pre-sarcopénicos, sarcopénicos moderados y graves utilizando distintos criterios de sarcopenia. Los datos fueron analizados utilizando prueba chi cuadrada y estadística Kappa. Se obtuvo como resultado que el 37,5% de las ancianas presentaron baja masa muscular, el 34,4%, debilidad muscular, el 3,1% presentaron incapacidad funcional para levantarse y caminar y el 25,9% para sentarse y levantarse de la silla. Considerando solamente la masa muscular, el 37,5% de la muestra fue clasificada como sarcopénica (moderada o grave) y, considerando los criterios del European Working Groups on Sarcopenia in Older People, el 15,6% obtuvo esa clasificación al evaluar la capacidad funcional con TUG y el 22,4% con STS. La concordancia entre las definiciones de sarcopenia varió de moderada a excelente (p<0,001). Entre las ancianas con integridad de la masa muscular (n=40), el 30% presentaron debilidad de prensión palmar, el 2,5% incapacidad en el TUG y el 25,7% en el STS. Fue concluido que las ancianas presentaron alta frecuencia de sarcopenia independientemente del criterio utilizado. Se observó moderada la excelente concordancia entre los criterios de sarcopenia investigados. La identificación de ancianos con integridad de la masa muscular coexistiendo con debilidad muscular e incapacidad funcional refuerza la importancia de la evaluación de los tres parámetros en el escenario clínico-científico. Palabras clave |

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“…2 The incidence of sarcopenia rises with aging and its prevalence is markedly increased in older adults. 5 In these patients, sarcopenia is considered primary, once this occurs in response to the myriad of physiological alterations associated with aging process (e.g., inflammation, oxidative stress). The most concern about sarcopenia is…”

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confidence: 99%

Why Should we Monitoring Sarcopenia in the Middle-Aged and Older Patient?

Junior¹

2017

HPMIJ

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Prevalence of sarcopenia in older Brazilians: A systematic review and meta‐analysis

Abstract: Sarcopenia is an emerging public health issue in Brazil. Attention should be paid to changes in prevalence rates over the next years because of the increase in the older population. Geriatr Gerontol Int 2017; 17: 5-16.

Cited by 95 publications

References 70 publications

Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis

Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis

Concordância de diferentes critérios de sarcopenia em idosas comunitárias

Why Should we Monitoring Sarcopenia in the Middle-Aged and Older Patient?

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