Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana

Kuma, Amma Benneh-Akwasi; Owusu-Ansah, Amma; Ampomah, Mary A.; Sey, Fredericka; Olayemi, Edeghonghon; Nouraie, Mehdi; Ofori-Acquah, Solomon Fiifi

doi:10.1371/journal.pone.0190347

Cited by 21 publications

(21 citation statements)

References 20 publications

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“…In contrast to this study, studies by Benneh-Akwasi Kuma et al, [29], indicated the risk of relative systemic hypertension and hypertension in sickle cell subjects. Benneh-Akwasi Kuma et al [29] corroborate studies of sickle cell subjects with low blood pressure adding that relative systemic hypertension appeared in male subjects with a steady increase in age, whereas, hypertension is uncommon and appears in subjects having a medical history of hypertension.…”

Section: Discussioncontrasting

confidence: 96%

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Nnaji¹,

Oguji²,

Orji³

et al. 2022

World J. Adv. Res. Rev.

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Background: Sickle cell disease is a common genetic disorder mainly characterized by vascular occlusion and haemolysis and it constitutes a major public health problem. The aim of this study is to assess the serum electrolyte levels in sickle cell patients attending the University of Nigeria Teaching Hospital, Enugu. Materials and methodology: A total of 66 subjects, ages 18 – 40 years, were recruited for this study with thirty sickle cell subjects (female = 16, Male = 14) as test subjects and thirty non-sickle cell subjects (female = 21, male = 9) as control subjects. A total of 5mls of venous blood was collected from each subject. The serum obtained from each sample was analyzed for serum electrolytes (sodium, potassium, chloride, and bicarbonate) by potentiometry using a sensacore autoanalyzer. The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 22. Results: Anthropometric results obtained from this study showed a significant decrease (P < 0.05) in mean ± SD of systolic blood pressure, diastolic blood pressure, and body mass index (BMI) in the test subjects compared to the control subjects respectively. The electrolyte analyses showed a significant increase (P < 0.05) in mean ± SD of potassium and chloride in the test subjects compared to the control subjects respectively. The control subjects have a non-significant increase (P > 0.05) mean ± SD of sodium compared to the sickle cell subjects while the sickle cell subject has a non-significant increase (P > 0.05) mean ± SD of bicarbonate compared to the control subjects. There was a positive correlation between sodium and bicarbonate, while in the other parameters; no significant correlation existed. Conclusion: This study concludes that sickle cell anaemia subjects are predisposed to electrolyte variations, hence, the need to check these electrolyte values in sickle cell subjects.

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Section: Discussioncontrasting

confidence: 96%

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Nnaji¹,

Oguji²,

Orji³

et al. 2022

World J. Adv. Res. Rev.

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“…Our prevalence is similar to that of 45% reported by Benneh-Akwasi Kuma et al in Ghana [20] as well as of 44% found by Makubi et al [21] and Gordeuk et al [6]. However, it is somewhat higher than that of 17% found by Becker et al [5] and Bodas et al [4], respectively.…”

Section: Discussionsupporting

confidence: 90%

Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study

Mboliasa¹,

Lepira²,

Makulo³

et al. 2018

WJCD

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Background: Although systemic hypertension is rarely seen in steady state sickle cell disease (SCD), relative hypertension has been reported to be associated with an increased risk of cardiovascular and renal complications. Objective: To determine the prevalence of BP patterns and assess factors associated with relative hypertension in sickle cell anemia (SCA) adult patients. Methods: Clinical data and office BP were obtained from 103 consecutive steady-state SCA adult patients (mean age 26 ± 7.9 years, 66% females, 22.3% on hydroxyurea) attending four healthcare centers providing SCD-specific care in Kinshasa. Seated BP was measured using an automated electronic device. Three consecutive blood pressure measurements were taken with 2 minutes interval between readings and the average of the 2 last readings was considered for the analyses. Normal BP, relative hypertension and systemic hypertension were defined as BP < 120/70 mmHg, 120 -139/70 -89 mmHg and ≥140/90 mmHg, respectively. Results: Normal BP, relative hypertension and systemic hypertension were observed in 56 (54%), 43 (42%) and 4 (4%) of SCA patients, respectively. In multivariate analysis, factors associated with relative hypertension were leg ulcer (aOR 2.05; 95%CI 1.77 -5.18; p = 0.016), central obesity (aOR 3.32; 95%CI 1.28 -6.24; p = 0.001), smoking (aOR 5.02; 95%CI 1.51 -9.50; p = 0.017), and microalbumiuria (aOR 3.44; 95%CI 1.44 -5.76; p = 0.035). Conclusion: Relative hypertension was a common finding in the present case series and associated with traditional cardiovascular risk factor as well as factors specific to SCD highlighting the need for measures to prevent its progression towards systemic hypertension and associated cardiovascular and renal disease.

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“…25 It has also been shown that patients with SCD and relative hypertension (high-normal blood pressure values of systolic 120-139 mm Hg and diastolic blood pressure 70-89 mm Hg) have both higher seCr levels and an increased risk of pulmonary hypertension when compared with SCD patients with lower blood pressures. 26,27 Microalbuminuria (defined as .4.5 mg/mmol) is an early manifestation of SCN, reaching a prevalence of over 50% in older patients. 28 In 4% to 12% of the patients, the proteinuria may progress to end-stage renal disease needing renal replacement therapy that is associated with increased mortality.…”

Section: Comments On Patients 1 Andmentioning

confidence: 99%

How I treat the older adult with sickle cell disease

Thein

Howard

2018

Blood

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With increasing survival, cumulative complications of sickle cell disease (SCD), which develop insidiously over time, are becoming more apparent and common in older patients, particularly those in their fifth decade and beyond. The older patient is also more likely to develop other age-related nonsickle conditions that interact and add to the disease morbidity. A common misconception is that any symptom in a SCD patient is attributable to their SCD and this may lead to delays in diagnosis and appropriate intervention. We recommend regular comprehensive reviews and monitoring for early signs of organ damage and a low threshold for the use of hydroxyurea and blood transfusions as preventative measures for end-organ disease. Treatable comorbidities and acute deterioration should be managed aggressively. Although the primary goal in management of the older adult with SCD is improving anemia and minimizing organ damage, the time has come for us to be more proactive in considering curative therapies previously offered to the younger patient. Curative or experimental interventions should be discussed early, before complications render the patients ineligible for these treatments.

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Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana

Cited by 21 publications

References 20 publications

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Blood Pressure Patterns and Factors Associated with Relative Hypertension among Steady State Sickle Cell Disease Patients in Kinshasa, Democratic Republic of the Congo: A Cross-Sectional Study

How I treat the older adult with sickle cell disease

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