Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Nnaji, Chisimdindu Frances; Oguji, None Cyprian Emeka; Orji, Kelvin Nkemakonam; Ikegwuonu, None Ifeoma Chinwe; Onuchukwu, Ifunanyachukwu Confidence; Adebisi, Sheriffdeen Adedolapo; Oguzie, Blessing Chinyere; Udensi, Carmilla Ijeoma; Nwabuona, Nchekwube Esther; Kelechi, Ukeoma Genevieve; Ofojama, Ebubechukwu Lovelyn; Ofoamalu, None Chisom Odinakachukwu; Okafor, Chisom Nwabundo

doi:10.30574/wjarr.2022.14.3.0567

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5,6] Diarrhea can lead to dehydration, electrolyte imbalances, and further complications in people with SCA. [7] Dehydration can exacerbate the risk of vaso-occlusive crises and other complications associated with the disease. [8] Managing diarrhea in individuals with SCA requires a multifaceted approach.…”

Section: Introductionmentioning

confidence: 99%

Managing gastrointestinal challenges: Diarrhea in sickle cell anemia

Obeagu,

Obeagu

2024

Medicine

View full text Add to dashboard Cite

Sickle cell anemia (SCA), a hereditary hemoglobinopathy, is characterized by the presence of abnormal hemoglobin and has long been associated with a wide range of complications. While much attention has been given to the condition hematological aspects, gastrointestinal complications, particularly diarrhea, have been relatively understudied and often overlooked. This publication delves into the management of gastrointestinal challenges, with a focus on diarrhea, in individuals living with SCA. The pathophysiology of SCA is intrinsically linked to gastrointestinal complications, and diarrhea is a common manifestation of this condition. This abstract publication outlines the key elements discussed in the full-length work, which includes the clinical presentation of diarrhea in these patients, the diagnostic tools used to evaluate the condition, and various management strategies to alleviate symptoms and enhance the overall quality of life for affected individuals. The paper emphasizes the importance of patient education, offering healthcare professionals valuable insights into how to inform and support patients in managing their conditions effectively. It also highlights the need for continued research to further our understanding of gastrointestinal challenges in SCA and to identify potential areas for future therapeutic interventions. Ultimately, the comprehensive management of diarrhea in individuals with SCA is vital for their overall well-being. This publication serves as a valuable resource for healthcare providers, researchers, and caregivers in addressing the gastrointestinal challenges that accompany SCA, ultimately working toward a better quality of life for those affected by this condition.

show abstract

Section: Introductionmentioning

confidence: 99%

Managing gastrointestinal challenges: Diarrhea in sickle cell anemia

Obeagu,

Obeagu

2024

Medicine

View full text Add to dashboard Cite

show abstract

“…Sickle cell disease (SCD), is a genetic disease associated with the human blood and it is one haemoglobinopathy that is most common among the other haemoglobinopathies, and hence, a major public health problem with over 200,000 babies born per year with SCD in Africa [1,2,3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of major liver enzymes activities among sickle cell subjects in Enugu South East of Nigeria

Ifeoma Chinwe Ikegwuonu,

Geoffrey Chukwuanugo Okeke,

Adanna Perpetua Ikebudu

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Objective: Sickle cell anemia is a condition resulting from inheritance of two abnormal allele of genes controlling β-globin formation. This haemoglobinopathy affects multiple organ system in the body. The hepatobiliary system is most commonly affected in sickle cell disease. This study assessed liver enzymes activities in sickle cell subjects in Enugu, Nigeria. Methods: We recruited about hundred subjects age (20-40years) for this study. Fifty sickle cell subjects (Male =22, Female=28) as test subjects and fifty non-sickle cell subjects (Male=24, Female=26) as control. Anthropometric indices were measured and five milliliters of blood sample collected from each participant for analysis of Alanine transaminase (ALT), alkaline phosphatase (ALP), and Aspartate transaminase (AST) using autoanalyser. Data were analysed using statistical package for the social sciences (SPSS) version 25. Results: The sickle cell subjects showed a significant decrease (P<0.05) in mean ± SD of systolic BP, diastolic BP and body mass index compared to control subjects. The liver enzymes analysis showed a statistical increase (P<0.05) in ALP and AST while a non-significant increase (P>0.05) exist in ALT of sickle cell subjects compared to non- sickle cell subjects. There is a positive correlation (P<0.05) in SBP vs. DBP, ALT vs. AST, ALT vs. BMI among the test subjects. Conclusion: This study suggests that there is increase in liver enzymes activities in sickle cell subjects compared to non- sickle cell subjects, which could lead to liver complications and hence, need for regular assessment.

show abstract

Assessment of serum electrolytes levels among sickle cell patients in South-Eastern Nigeria

Cited by 2 publications

References 26 publications

Managing gastrointestinal challenges: Diarrhea in sickle cell anemia

Managing gastrointestinal challenges: Diarrhea in sickle cell anemia

Assessment of major liver enzymes activities among sickle cell subjects in Enugu South East of Nigeria

Contact Info

Product

Resources

About