Prevalence of Red Blood Cell Alloantibodies in Blood Donors of Zanjan Province; the Preliminary Report of the North West of Iran

Babaei, Khadijeh; Esmaeilzadeh, Abdolreza; Asadi, Siamak; Sohrabi, Roya

doi:10.13005/bbra/2385

Cited by 5 publications

(10 citation statements)

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“…12–14 On contrary, some studies in India showed that it was blood group B which was the dominant one, 24 , 25 while studies in Iran and Europe indicated that blood group A was the predominant blood group. 26 The Rh-positive blood group was also the most predominant which covered 94.8%, similarly, a study conducted in Jimma, Bahir Dar, Gondar, Arba Minch, Jigjiga, and Debre Tabor regions of Ethiopia, indicated that Rh positive blood group was the most prevalent with 92.8%, 91.5%, 94.2%, 92.8%, and 95.6% and 91.5% frequency respectively. 10 , 11 , 20–23 Although, a study conducted in Gambela region of Ethiopia reported a slightly higher frequency of 19.37% for the Rh-negative blood group.…”

Section: Discussionmentioning

confidence: 71%

Prevalence of ABO and Rh Blood Group Among Volunteer Blood Donors at the Blood and Tissue Bank Service in Addis Ababa, Ethiopia

Debele

Fita

Tibebu

2023

JBM

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Background The discovery of the ABO blood group system and testing of blood donors highly reduced the fatalities associated with blood transfusion reactions and improved the safety of blood transfusion. Blood group antigens are found on the surface of red blood cells that are inherited biological characteristics that do not change throughout life in healthy individuals. Objective To determine the prevalence ABO and Rh blood groups Among Volunteer Blood Donors at Ethiopian blood and tissue bank service (EBTBS), Addis Ababa. Methods A cross-sectional study was carried out from January 2022 to May 2022, on 1700 volunteer blood donors to assess prevalence of ABO and Rh blood groups among volunteer blood donors at the Ethiopian blood and tissue bank service. All tests were performed using fully automated immunohematology analyzer (Galileo Neo Immucor). Data processing and analysis were undertaken by using Statistical Package for the Social Sciences (SPSS) version 26. An ethical clearance letter was obtained from Addis Ababa University and informed consent was also obtained from the participants of the study. Results A total of 1700 donors were included, of which 57% of donors were males. The majority of the donors belonged to the age group between 18 and 25 years old (53%). The antigen frequencies of ABO and Rh(D) blood group system showed that O was the most prevalent blood group 44.65% followed by A (28.41%), B (21.24%), and AB (5.71%). The Rh-positive donors were more prevalent (94.82%) as oppose to the Rh-negative (5.18%). Conclusion The knowledge of the distribution of blood groups is very important for blood banks and transfusion services which play an important role in the patient’s health care. The findings of the ABO blood group in this study were comparable to other studies conducted in Ethiopia.

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Section: Discussionmentioning

confidence: 71%

Prevalence of ABO and Rh Blood Group Among Volunteer Blood Donors at the Blood and Tissue Bank Service in Addis Ababa, Ethiopia

Debele

Fita

Tibebu

2023

JBM

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“…Of the 200 donors (130 (65%) males and 70 (35%) Females), eight (4%) were found to have alloantibodies to RBCs, in a study conducted in Iran on 75 donors of Zanjaian population by Babaei et al (3) alloantibodies were detected in serum of 6 donors (8%).…”

Section: Discussionmentioning

confidence: 96%

“…Red blood cell (RBC) alloantibodies, especially IgG class, are clinically significant because of the association with hemolytic disease of newborns (HDN), hemolytic transfusion reaction (HTR) and a significant reduction in lifespan of transfused red blood cells (3) .…”

Section: Introductionmentioning

confidence: 99%

“…Antibody screening test is a simple and inexpensive method for identification of large number of important antibodies; which are generally against minor blood group antigens (3) . Because of the importance of these alloantibodies, paucity of literature and variability in their reported prevalence in normal population, we decided to examine the frequency of occurrence of alloantibodies in blood donors.…”

Section: Introductionmentioning

confidence: 99%

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Red Blood Cell Alloantibodies in Healthy Egyptian Blood Donors

El-Faramawy

Hashem

Mostafa

2018

The Egyptian Journal of Hospital Medicine

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Background: Alloantibodies are antibodies that are produced in response to foreign antigens, the main stimuli responsible for erythrocyte alloantibodies in healthy adult donors are previous pregnancies and transfusions. Red blood cell (RBC) alloantibodies, especially IgG class, are clinically significant because of the association with hemolytic disease of newborns (HDN), hemolytic transfusion reaction (HTR) and a significant reduction in lifespan of transfused red blood cells. It has been stated that hemolytic reactions due to erythrocyte alloantibodies in donor blood is a relatively rare occurrence; however, they can occasionally cause severe transfusion reaction, particularly if given to infants and in the setting of massive transfusion. Objective: We aimed in this study to screen healthy Egyptian blood donors for the presence of red blood cells alloantibodies in a trial to prevent complications of blood transfusion, other secondary possible outcomes are to reveal the differential frequency of these alloantibodies among donors with previous blood transfusion, multiple pregnancies, different age groups and gender. Subjects and Methods: This study was carried out on 200 healthy Egyptian blood donors coming to Ain Shams University Hospitals Blood Banks. Data was collected on: gender, age, frequent donor or first time to donate, history of previous blood transfusion, number of pregnancies (in female donors), history of hepatitis or other viral infection, history of diabetes mellitus, hypertension, and history of recent surgery. Results: Sera from donors was subjected to alloantibody screening by manufacturer's antibody screening cells (Grifols I+II+III), when positive screening test, alloantibodies identification was done by manufacturer's antibody identification panel (Grifols), which consists of 11 panels. Out of the 200 donors, alloantibodies were detected in 8 donors (4%), a percent which is higher than other studies, may be due to the smaller sample size, alloantibodies were: anti-Kell in 1 case (12.5%), anti-M in 1 case (12.5%), and anti-C in 1 case (12.5%), anti-c in 1 case (12.5%), and anti P in 1 case (12.5%), and 3 (37.5%) cases were non-specific antibodies, 130(65%) of donors were males and 70 (35%) were females with a male to female ratio 1.8:1, their ages ranged from 19 years to 65 years with median of 32 years. Conclusion: Relation between alloantibodies and gender, multipara, repeated blood transfusion and previous surgeries was done showing statistically significance of previous surgeries and presence of allo-antibodies.

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“…The most common used method for detection of alloimmunization, was conventional tube technique (~80%), while gel method was used in minority (~20%) [5][6][7][8]. In the majority of studies, in addition to alloantibodies, autoantibody (8 out of 13 studies) (61.5%) also were detected [1,3,4,12]. Among these studies, the rate of autoimmunization ranges from 1-~19% [4,9].…”

Section: Alloimmunization In Thalassemia Major In Iranmentioning

confidence: 99%

Alloimmunization against Rh and Kell blood groups antigens is the main obstacle for blood transfusion in transfusion dependent thalassemia patients in Iran

Dorgalaleh¹,

Gholami²,

Shokuhiyan³

et al. 2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.

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Prevalence of Red Blood Cell Alloantibodies in Blood Donors of Zanjan Province; the Preliminary Report of the North West of Iran

Cited by 5 publications

References 0 publications

Prevalence of ABO and Rh Blood Group Among Volunteer Blood Donors at the Blood and Tissue Bank Service in Addis Ababa, Ethiopia

Prevalence of ABO and Rh Blood Group Among Volunteer Blood Donors at the Blood and Tissue Bank Service in Addis Ababa, Ethiopia

Red Blood Cell Alloantibodies in Healthy Egyptian Blood Donors

Alloimmunization against Rh and Kell blood groups antigens is the main obstacle for blood transfusion in transfusion dependent thalassemia patients in Iran

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