Background/Aim. The purpose of tests for transmittable diseases, as well as
determining ABO group, Rh typing, and the presence of clinically significant
erythrocyte antibodies, is to enable the appropriate selection of
blood/blood components for transfusion, to prevent or minimize adverse
effects of transfusion, and to identify donors whose units of
blood/components are not suitable for transfusion. The aim of the study was
to evaluate the presence of irregular erythrocyte antibodies as well as to
determine the specificity and origin of these antibodies in voluntary
donors. Methods. This prospective observational study, conducted from
January until July 2023, included samples of voluntary blood donors (BDs)
for antibody screening in the population of voluntary BDs in the territory
of Southeast Serbia. A total of 23,082 samples from healthy BD were examined
through this period. Results. The overall prevalence of irregular
anti-erythrocyte antibodies was 0.1125%, with anti-K, anti-D, and anti-E
being the most frequently identified alloantibodies. Out of a total of 26
donors with positive screening results, 11 (42.32%) had alloantibodies, and
15 (57.68%) had antibodies of undetermined specificity. A positive antibody
test was observed more frequently in male donors, and the age range of 51
years and above accounted for the majority of positive cases. Conclusion.
Immunohematological testing, including antibody screening in voluntary BDs,
is important for safe blood transfusion and is of great clinical importance.
Likewise, it reduces the risk of complications due to incompatible
transfusions.