Prevalence of Psychiatric Disorders in Thyroid Diseased Patients

Placidi, Gp; Boldrini, Maura; Patronelli, A.; Fiore, Emilio; Chiovato, Luca; Perugi, Giulio; Marazziti, Donatella

doi:10.1159/000026545

Cited by 105 publications

(75 citation statements)

References 17 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Placidi et al looked at 93 patients with different thyroid dysfunctions and found 63% with a psychiatric diagnosis. 10 In Brazil, a multicentric study of morbidity in the general population found 18% prevalence of anxiety disorder and 3-10% of depression but no correlation with thyroid function was made.…”

Section: Introductionmentioning

confidence: 99%

Subclinical hypothyroidism: psychiatric disorders and symptoms

Almeida

Brasil

Costa

et al. 2007

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

A b s t r a c t Objective: To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism. Method: Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 μU/ml) and normal FT 4 , and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were evaluated. Psychiatric diagnosis was based on the Structured Clinical Interview Diagnostic for the DSM-IV axis I (SCID-I/DSM-IV), the psychopathological symptoms on Hamilton anxiety and depression scales, and the Beck Inventory. Results: Our data showed an increased prevalence of psychiatric disorders in the subclinical hypothyroidism patients when compared to the euthyroid group (45.7% vs 25.6%; p = 0.025), mood disorders being the most frequent. The prevalence of depressive symptoms based on Beck's Scale among subclinical hypothyroidism patients was about 2.3 times higher than among euthyroid ones (45.6% vs 20.9%, p = 0.006). Anxiety symptoms were also more frequent among subclinical hypothyroidism patients (87.0% vs 60.5%, p < 0.001), mainly clinical anxiety (44.6% vs 23.3%; p = 0.001). Conclusion: Our results showed a significant association of subclinical hypothyroidism with psychiatric disorders and an increased frequency of subsyndromic depression and anxiety symptoms in subclinical hypothyroidism in relation to the euthyroid group.Descriptors: Hypothyroidism; Anxiety disorders; Mood disorders; Symptoms; Prevalence Resumo Objetivo: Avaliar a prevalência de sintomas e alterações psiquiátricas em pacientes com hipotireoidismo subclínico. Método: Foram estudados 94 pacientes ambulatoriais com pelo menos duas dosagens plasmáticas elevadas de tireotropina (> 4 μU/ml) e com T 4 livre normal e, 43 eutireoidianos, ambos os grupos do HUCFF-UFRJ. Para diagnóstico psiquiátrico foi utilizada a entrevista clínica estruturada do eixo I (SCID-I/DSM-IV) e, para sintomas psicopatológicos, as escalas de ansiedade e depressão de Hamilton (HAM-A e HAM-D) e inventário de Beck. Resultados: Encontramos uma prevalência aumentada de transtornos psiquiátricos no hipotireoidismo subclínico em comparação ao grupo eutireoidiano (45,7% vs 25,6%; p = 0,025), sendo o transtorno do humor o de maior freqüência. Sintomas de depressão no grupo com hipotireoidismo subclínico foram cerca de 2,3 vezes mais freqüentes que entre os eutireoidianos (45,6% vs 20,9%; p = 0,006) quando o instrumento utilizado foi a escala de Beck. Da mesma forma, sintomas de ansiedade também foram mais freqüentes no hipotireoidismo subclínico (87,0% vs 60,5%; p < 0,001), principalmente ansiedade clínica (44,6% vs 23,3%; p = 0,001). Conclusão: Os resultados indicaram uma associação do hipotireoidismo subclínico com os transtornos psiquiátricos, além de uma freqüência aumentada de sintomas de depressão e ansiedade subsindrômicos em relação ao grupo eutireoidiano.

show abstract

Section: Introductionmentioning

confidence: 99%

Subclinical hypothyroidism: psychiatric disorders and symptoms

Almeida

Brasil

Costa

et al. 2007

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…A recent survey has shown an annual incidence of 32.7/100 000 adults in Stockholm county (2). Mental symptoms such as nervousness, anxiety, poor concentration and personality changes are prominent (3)(4)(5)(6)(7). Long-term neuropsychiatric symptoms following hyperthyroidism have been shown even in patients who have been successfully treated (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Hyperthyroidism and suicide: a retrospective cohort study in Sweden

Abraham-Nordling

Lönn²,

Wallin³

et al. 2009

European Journal of Endocrinology

View full text Add to dashboard Cite

Objectives: Mental symptoms and impaired quality of life commonly occur in patients treated for hyperthyroidism. Our aim was to determine whether a history of hyperthyroidism implies an increased risk of suicide. Results: The number of observed suicide deaths was 134 in the study cohort. A naive comparison with the age-, sex-and calendar period-matched general Swedish population yielded a moderately increased standardized mortality ratio (SMR), but stratifications revealed that the excess was mainly driven by women from Stockholm, whose baseline suicide risk was higher than for women in the rest of Sweden. Using the population rates from Stockholm, the SMR among Stockholm women with Graves' disease was 1.14 (95% confidence intervals (CI) 0.66-1.86) and toxic goitre 0.99 (95% CI 0.51-1.72). A direct comparison between the study cohort and the combined comparison cohorts, with multiple adjustments (including adjustment for residence in Stockholm), yielded a relative risk of suicide of 0.93 (0.68-1.26). Conclusions: This study did not confirm an increased risk of suicide among patients treated for hyperthyroidism.

show abstract

“…As mental disturbances are frequent among HIV patients [13][14][15][16] and among patients with chronic diseases [17][18][19][20][21][22] it is possible that HTLV patients might be more prone to mental disturbance. Our objective was to estimate the frequency of mental disturbances in HTLV-1 patients, with and without associated clinical symptoms.…”

mentioning

confidence: 99%

Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil

Carvalho¹,

Galvão-Phileto²,

Lima³

et al. 2009

Braz J Infect Dis

View full text Add to dashboard Cite

Viral infections and chronic diseases have been associated with psychiatric disorders. Among these, increased depression has been reported in HTLV-1 patients. However, no studies on the prevalence of other mental disturbances have been carried out in these patients. Salvador is the city with the highest rate of infection with HTLV-1 in Brazil and it is estimated that approximately 40,000 inhabitants are infected. In our cross sectional study, we examined the frequency of mental disturbances in 50 HTLV-1 seropositive patients followed at the Centro Integrativo e Multidisciplinar de HTLV e Hepatites Virais (CHTLV) of the Escola Bahiana de Medicina e Saude Pública (EBMSP) in Salvador from January to November 2007. We used a questionnaire to collect clinical-epidemiologic data and the Mini International Neuropsychiatric Interview Brazilian Version 5.0.0 (M.I.N.I.) to evaluate the psychiatric disorders. The Statistical Package for Social Sciences (SPSS) was used for the analyses. Twenty-one (42%) HTLV-1 patients had a psychiatric co-morbidity; 17(34%) had mood disorders, 11 (22%) were anxious and one (2%) was an alcoholic. We found a high frequency of mental disturbances among HTLV-1 infected individuals, suggesting a possible association of this infection with psychiatric diseases.

show abstract

Prevalence of Psychiatric Disorders in Thyroid Diseased Patients

Cited by 105 publications

References 17 publications

Subclinical hypothyroidism: psychiatric disorders and symptoms

Subclinical hypothyroidism: psychiatric disorders and symptoms

Hyperthyroidism and suicide: a retrospective cohort study in Sweden

Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil

Contact Info

Product

Resources

About