Prevalence of pertussis IgG antibodies in children in Palermo, Italy

Stroffolini, Tommaso; Giammanco, Anna; Taormina, Susanna; Nisticò, Lorenza; Chiarini, A; Crescenzo, Loredana De; Lupo, F.A.; Nicosia, Vincenzo; Torres, G.; Valenza, A.

doi:10.1007/bf01650708

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…This age group still accounts for the highest number of reported pertussis cases in some countries including Italy, Sweden and the former West Germany, where immunization is limited. [10,26,102,103] …”

Section: Populations Susceptible To Pertussismentioning

confidence: 99%

Which Strategy for Pertussis Vaccination Today?

Girard

2002

Pediatric Drugs

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Pertussis (whooping cough) remains an epidemic disease responsible for infant and child morbidity and mortality, and is perceived as a serious public health problem. Since the widespread use of whole-cell pertussis vaccines in the 1940s, vaccination programs have varied greatly between countries. National specificity is a function of several factors. The most important are: vaccine efficacy and tolerability;vaccine coverage and distribution; and vaccine acceptance by parents and professionals. During the 1970s, Sweden, England, Wales and Japan provided contrasting examples of the attitude of health authorities to the use of whole-cell vaccines. The increase in pertussis incidence was noted as a consequence of active opposition to this vaccine. The re-emergence of pertussis in the 1990s, in countries with high vaccination coverage and increased incidence of disease in individuals >15 years and <6 months of age, has drawn attention to the role of booster doses of pertussis vaccines and their introduction into regular vaccination programs. The use of acellular vaccines for booster doses for adolescents and adults would seem unambiguous because of their decreased reactogenicity, although the exact schedule has yet to be established. The choice between the two kinds of vaccines is more difficult for primary courses, where safety and efficacy profiles are similar, and the attitude towards acellular vaccines varies from country to country. In this case, the strategy adopted results from the national history of pertussis infection and from the quality of the available whole-cell vaccine. Two contrasting examples are the US, where acellular vaccines were licensed for the primary series in the 1990s, and the UK, where whole-cell vaccines are exclusively used for primary immunization. The changing epidemiology of pertussis, and its local diversification, would suggest that at present it is difficult to define a single worldwide strategy with only one kind of vaccine and one schedule. In order to control pertussis incidence, each country should continue to determine the best national vaccination program established in very close relation to the past and present epidemiological situation and available healthcare resources.

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Section: Populations Susceptible To Pertussismentioning

confidence: 99%

Which Strategy for Pertussis Vaccination Today?

Girard

2002

Pediatric Drugs

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“…Although the reported incidence of pertussis has decreased worldwide since the advent and licensure of wholecell Bordetella pertussis vaccines, demand for the accurate laboratory diagnosis of pertussis persists (3,15,16). Laboratory confirmation is indispensible to the clinical and epidemiologic responses to pertussis outbreaks in developed countries and the high morbidity in communities and developing nations with low vaccination compliance (2,3,10,13,14). The recent evaluations of the immunogenicities and protective efficacies of the latest acellular vaccines exemplify the research applications of diagnostic laboratory methodology.…”

mentioning

confidence: 99%

Rapid immunodot technique for identifying Bordetella pertussis

1993

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We developed and evaluated a rapid test with monoclonal antibodies to identify cultures of Bordetella pertussis. Samples of 5 ,li of cells suspended in formalin-saline were dried onto a nitrocellulose disk. The disk was placed in a filtration device, and 5-I,l volumes of murine monoclonal antibody directed against B. pertussis lipooligosaccharide and peroxidase conjugate were added consecutively, with washing after each addition. The disk was removed and immersed in peroxidase substrate solution. All of 66 B. pertussis isolates confirmed by direct fluorescent-antibody assay were correctly identified by using four different monoclonal antibodies. One of the monoclonal antibodies did not react with over 20 bacterial species tested, including other Bordetella, Acinetobacter, Haemophilus, MoraxeUla, Mycobacterium, Neisseria, and Staphylococcus spp. This technique detected .2 ,ug of lipooligosaccharide per ml or 25 x 108 B. pertussis cells per ml. This rapid procedure used small amounts of reagents, needed less equipment, and was less subjective and more specific than the direct fluorescent-antibody assay.

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Seroepidemiology of pertussis infection in an urban childhood population in Cameroon

et al. 1991

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In 1989, the prevalence of IgG antibodies to pertussis toxin (PT) in a sample of 367 unvaccinated apparently healthy children 5-14 years old was estimated by ELISA in Kumba City (Cameroon). Children were recruited using a systematic random sampling from six primary schools located in different districts of the city. The sample was representative of the various socioeconomic classes. The overall prevalence was 75%; it increased from 62% in 5 year old children to 81% in children 12-14 years old (P less than 0.01). IgG antibody prevalence was positively related to the family size. Children belonging to households of nine or more members had a 2.2-fold risk (C.I. 95 per cent = 1.1-4.6) of previous exposure to B. pertussis infection. No association was found with the father's occupation (O.R. = 1). These findings demonstrate a great impact of pertussis infection in Cameroon, with a nearly total exposure by late childhood.

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Prevalence of pertussis IgG antibodies in children in Palermo, Italy

Cited by 6 publications

References 11 publications

Which Strategy for Pertussis Vaccination Today?

Which Strategy for Pertussis Vaccination Today?

Rapid immunodot technique for identifying Bordetella pertussis

Seroepidemiology of pertussis infection in an urban childhood population in Cameroon

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