Prevalence of peripheral artery disease (PAD) and factors associated: An epidemiological analysis from the population-based Screening PRE-diabetes and type 2 DIAbetes (SPREDIA-2) study

Río, Víctor Cornejo Del; Mostaza, José María; Lahoz, Carlos; Sánchez-Arroyo, V.; Sabín, Concesa; López, Silvia; Patrón, P; Fernandez-Garcia, Pedro J.; Fernández-Puntero, Belén; Vicent, David; Montesano-Sanchez, Luis; García-Iglesias, Francisca; González-Alegre, Teresa; Estirado, Eva; Laguna, Fernando Ballester; Burgos‐Lunar, Carmen de; Gómez-Campelo, Paloma; Abánades-Herranz, Juan Carlos; Miguel‐Yanes, José M. de; Salinero-Fort, Miguel Á.

doi:10.1371/journal.pone.0186220

Cited by 34 publications

(14 citation statements)

References 64 publications

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“…Peripheral arterial disease usually seriously affects the daily quality of life of patients and imposes huge personal and societal healthcare burdens [ 22 , 23 ]. To the best of our knowledge, this is the first study to evaluate the association between serum Cyr61 levels and the risk of PAD.…”

Section: Discussionmentioning

confidence: 99%

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Feng

Sun

et al. 2020

Cardiovasc Diabetol

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Background The prevalence of peripheral artery disease (PAD) is obviously increased in patients with diabetes. Existing evidence shows that cysteine-rich angiogenic inducer 61 (Cyr61), a 40-kD secreted protein, plays important roles in regulating cellular physiological processes. Recent studies have demonstrated a significant correlation between serum Cyr61 and atherosclerosis. However, the relationship between Cyr61 levels and PAD in patients with type 2 diabetes (T2DM) remains obscure. Methods Data from a total of 306 subjects with T2DM were cross-sectionally analysed. The extent of PAD was determined by using the Fontaine classification, which defines four stages. We measured serum Cyr61 concentrations by ELISA in subjects with and without PAD at Fontaine’s stage II, III, or IV. Logistic regression models were used to examine the independent association of Cyr61 with PAD. Results Out of the 306 subjects enrolled, 150 were free from PAD, while 156 had clinically significant PAD. In subjects with PAD, the prevalences of Fontaine classification stages II, III and IV were 48.7%, 32.1%, and 19.2%, respectively. Patients with more advanced PAD had significantly higher Cyr61 (P for trend < 0.001). The prevalence of PAD on the basis of severity increased with increasing Cyr61 quartiles (all P values for trends < 0.001), and the severity of PAD was positively correlated with Cyr61 quartiles (r = 0.227, P = 0.006). The association of Cyr61 levels with PAD remained after adjusting for major risk factors in a logistic regression analysis. Conclusions Our results demonstrated that Cyr61 was significantly increased in PAD patients with T2DM and that Cyr61 levels were positively associated with disease severity. Cyr61 could be a promising biomarker and further studies are needed to assess its clinical utility.

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Section: Discussionmentioning

confidence: 99%

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Feng

Sun

et al. 2020

Cardiovasc Diabetol

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“…The possible risk factors for diabetes-related lower limb amputations, as reported in previous studies, include age, sex, educational attainment, renal function, hypertension, heart disease, duration of diabetes, micro- and macrocomplications of diabetes, and glycemic control. [ 27 – 29 ] It is widely known that peripheral arterial disease is an important risk factor for amputation, and the prevalence of peripheral arterial disease was significantly higher in men than in women, [ 30 , 31 ] and this may be one of the reasons why the male sex is associated with a higher risk of lower limb amputations. Many factors influence the decision of whether or not to remove a limb including disease severity, comorbidities, social and individual patient factors, quality of primary care, and prevailing medical opinion.…”

Section: Discussionmentioning

confidence: 99%

Impact of the pay-for-performance program on lower extremity amputations in patients with diabetes in Taiwan

Sheen¹,

Kung

Kuo³

et al. 2018

Medicine

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Patients with diabetes are at a high risk of lower extremity amputations and may have a reduced life expectancy. Taiwan has implemented a diabetes pay-for-performance (P4P) program providing team care to improve the control of disease and avoid subsequent complications. Few studies investigated the effects of adopting a nationalized policy to decrease amputation risk in diabetes previously. Our study aimed to analyze the impact of the P4P programs on the incidence of lower extremity amputations in Taiwanese patients with diabetes.This was a population-based cohort study using the Taiwan National Health Insurance Research Database (which provided coverage for 98% of the total population in Taiwan) from 1998 to 2007. Patients with diabetes were identified based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) diagnostic codes. We linked procedure codes to inpatient claims to identify patients hospitalized for nontraumatic lower extremity amputations.A total of 9738 patients with diabetes with amputations were enrolled (mean age ± standard deviation: 64.4 ± 14.5 years; men: 63.9%). The incidence of nontraumatic diabetic lower extremity amputations decreased over the time period studied (3.79–2.27 per 1000 persons with diabetes). Based on the Cox proportional hazard regression model, male sex (hazard ratio: 1.83, 95% confidence interval [CI] 1.76–1.92), older age, and low socioeconomic status significantly interact with diabetes with respect to the risks of amputation. Patients who did not join the P4P program for diabetes care had a 3.46-fold higher risk of amputation compared with those who joined (95% CI 3.19–3.76).The amputation rate in Taiwanese diabetic patients decreased over the time period observed. Diabetes in patients with low socioeconomic status is associated with an increased risk of amputations. Our findings suggested that in addition to medical interventions and self-management educations, formulate and implement of medical policies, such as P4P program, might have a significant effect on decreasing the diabetes-related amputation rate.

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“…Um ITB com valores > 1,30 é peculiar quando associado arigidez da parede vascular (3) . Foram detectados trabalhadores de enfermagem com essa característica, e esta pode estar relacionada a uma calcificação da camada média das artérias, com possibilidade de torná-las não compressíveis (1) .…”

Section: Discussionunclassified

“…A medida do índice tornozelo-braquial (ITB) é um recurso eficaz, simples, não invasivo, de baixo custo e fácil realização, capaz de detectar a doença arterial obstrutiva crônica (DAOP), com ou sem sintomatologia, e o processo aterosclerótico (1)(2)(3) . O ITB representa a razão entre o maior valor da pressão arterial sistólica do tornozelo das artérias pediosa e tibial posterior e a medida das artérias braquiais.…”

Section: Introductionunclassified

“…Estas alterações comprometem o fluxo sanguíneo tanto para o surgimento de DAOP quanto paradoença arterial carotídea e, assim, aumento da doença cardiovascular. Contudo, um valor de ITB > 0,9, pode estar relacionado à doença aterosclerótica difusa, com endurecimento arterial devido a calcificação da camada média e rigidez da parede vascular (1,3) .…”

Section: Introductionunclassified

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<b> Índice tornozelo-braquial e fatores de risco cardiovascular em profissionais de enfermagem/ Ankle-braquial index and cardiovascular risk factors in nursing professionals<b>

Motta¹,

Rocha²,

Maia³

et al. 2018

Cienc. Cuid. Saúde

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Estudo transversal no qual foram avaliados 94 trabalhadores de enfermagem da rede pública de saúde. O objetivo foi identificar a prevalência da alteração da medida do índice tornozelo-braquial e fatores de risco cardiovascular em trabalhadores de enfermagem. Os aspectos éticos foram atendidos. Os dados foram obtidos por meio de entrevista com roteiro estruturado. A prevalência da medida de ITB alterada foi de 30 (31,9%; IC; 22,3-42,6). Verificou-se que 83% eram técnicos, 91,5% do sexo feminino, idade entre 18 a 45 anos, cor da pele branca, pertencente à classe econômica A/B e com mais de cinco anos de formado. Dos fatores de risco cardiovascular, verificou-se prevalência de histórico familiar de alteração cardiovascular (73,4%), ter mais de quatro fatores de riscos cardiovasculares (73,4%), IMC ≥ 25 kg/m² (68,1%)e apresentar circunferência da cintura com risco moderado a elevado (63,8%). A não realização de atividade física (RP: 2,36; IC95%: 1,29-4,32) foi independentemente associada à alteração da medida de ITB. A coexistência de fatores de risco cardiovascular associados a alterações da medida de ITB nos trabalhadores de enfermagem reporta a necessidade de intervenções na saúde destas pessoas.

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Prevalence of peripheral artery disease (PAD) and factors associated: An epidemiological analysis from the population-based Screening PRE-diabetes and type 2 DIAbetes (SPREDIA-2) study

Cited by 34 publications

References 64 publications

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Impact of the pay-for-performance program on lower extremity amputations in patients with diabetes in Taiwan

<b> Índice tornozelo-braquial e fatores de risco cardiovascular em profissionais de enfermagem/ Ankle-braquial index and cardiovascular risk factors in nursing professionals<b>

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