Prevalence of Parkinson's disease in Northern Jordan

Alrefai, Ali; Habahbih, Majed; Alkhawajah, Mohammad M.; Darwish, M.A.; Batayha, Waleed; Khader, Yousef; El‐Salem, Khalid

doi:10.1016/j.clineuro.2009.08.010

Cited by 17 publications

(5 citation statements)

References 22 publications

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“…In contradistinction, Khedr et al [21] found a PD prevalence of 557.4 per 100,000 in a recent cross-sectional survey of the Egyptian district of Assiut, a rate much higher than the rate previously observed in the Arab world. The authors of that study highlighted that their study population was rural, possibly explaining this difference, with the majority of other studies comprising urban populations [18,19,21] .…”

Section: Epidemiological and Clinical Studiesmentioning

confidence: 89%

“…One study conducted in 3 tertiary referral centers in Irbid, Jordan, reported prevalence of 37.4 per 100,000 [18] ; a second 1986 population Libyan study reported a prevalence rate of 31.4 per 100,000 [19] ; and a third Tunisian study reported a crude prevalence of 43 per 100,000 [20] . In contradistinction, Khedr et al [21] found a PD prevalence of 557.4 per 100,000 in a recent cross-sectional survey of the Egyptian district of Assiut, a rate much higher than the rate previously observed in the Arab world.…”

Section: Epidemiological and Clinical Studiesmentioning

confidence: 99%

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Parkinson's Disease in the Gulf Countries: An Updated Review

Alamri¹,

MacAskill²,

Anderson³

et al. 2015

Eur Neurol

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Background: The Arabian Gulf region is a rapidly developing part of the world. With the increase in average life-expectancy, idiopathic Parkinson's disease (PD), is also expected to increase in prevalence. Furthermore, the high rate of consanguinity among Arabs probably makes familial cases of PD more likely to be encountered than other areas in the world. This review provides an update on the published literature on sporadic and familial PD in Gulf Arabs. Summary: Although the Arab population of this region shares religious beliefs and demographic characteristics with other Arabs, their environmental exposures and genetic makeup may be different. This could account for the relatively low prevalence of PD reported in the Al-Thugba study (27 per 100,000) compared with prevalence rates by most other studies on Arab (mainly North African) populations (31.4-557.4 per 100,000). Key Messages: Gulf countries are considered rich countries, which makes conducting nation-wide or even international studies logistically easier than it is in many other countries. Such multinational research can be organized by the existing Gulf Cooperation Council, or through a collaboration of the Ministries of Health. This would, hopefully, culminate in the introduction of more research centers, as well as the implementation of better health care policies and practices for the ageing community.

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Section: Epidemiological and Clinical Studiesmentioning

confidence: 89%

Section: Epidemiological and Clinical Studiesmentioning

confidence: 99%

Parkinson's Disease in the Gulf Countries: An Updated Review

Alamri¹,

MacAskill²,

Anderson³

et al. 2015

Eur Neurol

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“… 15 , 16 However, there is a dearth of information about epidemiological features of PD not only in the Iranian population, but also in the greater Eastern Mediterranean World Health Organization (WHO) region, where different populations with specific environmental and ethnogenetic properties live. Data from Arabic countries in the Middle East are also absent, except for recent surveys in Jordan 17 and Egypt 18 showing prevalence rates of 58.8 and 452.1 per 100,000, respectively, which demonstrates a wide range of variation.…”

Section: Introductionmentioning

confidence: 95%

Medium-to-high prevalence of screening-detected parkinsonism in the urban area of Tehran, Iran: data from a community-based door-to-door study

Fereshtehnejad¹,

Shafieesabet²,

Rahmani³

et al. 2015

NDT

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IntroductionParkinsonism occurs in all ethnic groups worldwide; however, there are wide variations in the prevalence rates reported from different countries, even for neighboring regions. The huge socioeconomic burden of parkinsonism necessitates the need for prevalence studies in each country. So far, there is neither data registry nor prevalence information on parkinsonism in the Iranian population. The aim of our study was to estimate the prevalence rate of probable parkinsonism in a huge urban area in Iran, Tehran using a community-based door-to-door survey.Materials and methodsWe used a random multistage sampling of the households within the network of health centers consisting of 374 subunits in all 22 districts throughout the entire urban area of Tehran. Overall, 20,621 individuals answered the baseline checklist and screening questionnaire and data from 19,500 persons aged ≥30 years were entered in the final analysis. Health care professionals used a new six-item screening questionnaire for parkinsonism, which has been previously shown to have a high validity and diagnostic value in the same population.ResultsA total of 157 cases were screened for parkinsonism using the validated six-item questionnaire. After age and sex adjustment based on the Tehran population, the prevalence of parkinsonism was calculated as 222.9 per 100,000. Using the World Health Organization’s World Standard Population, the standardized prevalence rate of parkinsonism was 285 per 100,000 (95% confidence interval 240–329). The male:female ratio of probable parkinsonism was calculated as 1.62, and there was a significant increase in the screening rate by advancing age.ConclusionThe calculated rates for the prevalence of parkinsonism in our study are closer to reports from some European and Middle Eastern countries, higher than reports from Eastern Asian and African populations, and lower than Australia. The prevalence rate of >200 in 100,000 for parkinsonism in Tehran, Iran could be considered a medium-to-high rate.

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“…There are also genetic aspects that have to be considered. For instance, the LRRK2, G2019S, autosomal dominant PD with inadequate penetrance and autosomal recessive inheritance patterns were discovered in a genomic analysis of familial PD in Tunisia [ 8 ] and are now known to be prevalent in North African Arabs in Gulf cooperation council countries (GCC) with Arabic population [ 8 , 9 , 10 ]. This could be due to ancestry disparities between Arabs from the Gulf Cooperation Council and Arabs from North Africa, with the latter being considerably more closely linked to Berber ancestry [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

First Two-Year Observational Exploratory Real Life Clinical Phenotyping, and Societal Impact Study of Parkinson’s Disease in Emiratis and Expatriate Population of United Arab Emirates 2019–2021: The EmPark Study

Metta

Ibrahim²,

Loney

et al. 2022

JPM

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Background: Phenotypic differences in Parkinson’s Disease (PD) among locals (Emiratis) and Expatriates (Expats) living in United Arab Emirates have not been described and could be important to unravel local aspects of clinical heterogenicity of PD pointing towards genetic and epigenetic variations. Objective: To investigate the range and nature of motor and nonmotor clinical presentations of PD and its impact on time to diagnosis, local service provisions, and quality of life in Emiratis and Expats in UAE, as well as address the presence of current unmet needs on relation to care and etiopathogenesis of PD related to possible genetic and epigenetic factors. Methods: a cross-sectional one point in time prospective, observational real-life study of 171 patients recruited from PD and Neurology clinics across United Arab Emirates from 2019–2021. Primary outcomes were sociodemographic data, motor and nonmotor symptoms (NMS), including cognition and sleep, and quality of life (QOL) assessments, Results: A total of 171 PD patients (52 Emiratis 119 Expats) were included with mean age (Emiratis 48.5 (13.1) Expats 64.15 (13.1)) and mean disease duration (Emiratis 4.8 (3.2) Expats 6.1 (2.9)). In the Emiratis, there was a significant mean delay in initiating treatment after diagnosis (Emiratis 1.2 (0.9) Expats 1.6 (1.1)), while from a clinical phenotyping aspect, there is a high percentage of akinesia 25 (48.1) or tremor dominant (22 (42.3)) phenotypes as opposed to mixed subtype 67 (56.3) in Expat cohorts; double tremor dominant, especially Emirati females (25%), had a predominant lower limb onset PD. Both Emirati (27.9 (24.0)) and Expat 29.4 (15.6) showed moderate NMS burden and the NMS profile is dominated by Sleep, Fatigue, Mood, Emotional well-being 3.0 (1.1) and Social Stigma 3.5 (0.9) aspects of PDQ8 SI measurements are predicted worse QOL in Emiratis, while lack of social support 2.3 (1.3) impaired QOL in Expat population. Awareness for advanced therapies was low and only 25% of Emiratis were aware of deep brain surgery (DBS), compared to 69% Expats. Only 2% of Emiratis, compared to 32% of Expats, heard of Apomorphine infusion (CSAI), and no (0%) Emiratis were aware of intrajejunal levodopa infusion (IJLI), compared to 13% of expats. Conclusion: Our pilot data suggest clinical phenotypic differences in presentation of PD in Emiratis population of UAE compared to expats. Worryingly, the data also show delayed treatment initiation, as well as widespread lack of knowledge of advanced therapies in the Emirati population.

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Prevalence of Parkinson's disease in Northern Jordan

Cited by 17 publications

References 22 publications

Parkinson's Disease in the Gulf Countries: An Updated Review

Parkinson's Disease in the Gulf Countries: An Updated Review

Medium-to-high prevalence of screening-detected parkinsonism in the urban area of Tehran, Iran: data from a community-based door-to-door study

First Two-Year Observational Exploratory Real Life Clinical Phenotyping, and Societal Impact Study of Parkinson’s Disease in Emiratis and Expatriate Population of United Arab Emirates 2019–2021: The EmPark Study

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