Prevalence of oral lesions in and dental needs of patients with newly diagnosed acute leukemia

Watson, Erin; Wood, Robert E.; Maxymiw, W.G.; Schimmer, Aaron D.

doi:10.1016/j.adaj.2018.01.019

Cited by 14 publications

(47 citation statements)

References 19 publications

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“…14 Thus, manifestations of this haematological illness can be screened and diagnosed by oral healthcare providers. 12 In this review, we noticed that individuals in their fifties were the most affected by oral manifestations of leukaemic infiltration; however, there were differences regarding the leukaemia subtypes. The reported cases described 40-49-year-old individuals as the most affected, and 51.4% of the sample was diagnosed with AML.…”

Section: Discussionmentioning

confidence: 94%

“…11,18 In the current study, 37% of the reports described leukaemic infiltration in the gingiva. According to Watson et al, 12 the most common oral manifestation was bleeding, observed in 34 (12.9%) of the 263 documented patients. Gingival enlargement was also observed in 15 (5.7%) patients and was more associated with AML.…”

Section: Discussionmentioning

confidence: 97%

“…By contrast, a study found that the median age of individuals with acute leukaemia was 61 years. 12 Although ALL affected mainly the paediatric population (mean age of 11.7 years), 5 the occurrence of AML among individuals in this age group was very rare. We identified six cases of AML in children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…8,11 A study found that about 31% of patients with a recent diagnosis of acute leukaemia showed oral signs, the most common being oral bleeding (12.9%), followed by gingival enlargement (5.7%). 12 Due to the varied clinical manifestations in the oral and maxillofacial region, the diagnosis of leukaemic infiltration is not quite straightforward. 8,10 In this respect, dentists may play an important role in the diagnosis of these oral alterations by excluding other pathological processes.…”

Section: Introductionmentioning

confidence: 99%

“…8,10 In this respect, dentists may play an important role in the diagnosis of these oral alterations by excluding other pathological processes. 12 Herein, we aimed to integrate the available data into a comprehensive analysis of leukaemic infiltration in the oral and maxillofacial region, emphasizing the clinical manifestations, imaginological characteristics and management of the condition, as well as survival.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Leukaemic infiltration in the oral and maxillofacial region: An update

SENA

Arruda

Costa

et al. 2021

J Oral Pathology Medicine

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Background:The purpose of this study was to integrate the available data published on leukaemic infiltration in the oral and maxillofacial region into a comprehensive analysis of its clinical manifestations, imaginological characteristics, management and survival.Materials and methods: An electronic search with no publication date restriction was undertaken in October 2020 in the following databases: PubMed, Web of Science, Scopus and Embase. Overall survival was calculated by survival analysis with the Kaplan-Meier test. A critical appraisal of included articles was performed using the Joanna Briggs Institute tool.Results: A total of 63 studies including 68 patients were selected for data extraction. The most common haematologic diagnosis was acute myeloid leukaemia (47%).The most affected individuals were 40 to 49 years old (20.9%). The male-to-female ratio was 1.2:1. The gingiva was the most affected site (37%). Swelling/mass/oedema (33.7%) and enlargement/hyperplasia/hypertrophy (25.5%) were the main clinical findings. Osteolytic lesions with bone destruction were the main imaginological characteristics among the reported cases. Follow-up was available for 36 patients.Overall, within the 21-month follow-up, the survival probability dropped to 14.3%. Conclusion:A considerable number of studies reported oral manifestations mainly in individuals with the acute form of leukaemia. Children and adults were affected, but the fifth decade of life was the most common. Dentists should be vigilant since these manifestations may be important for a diagnosis and for the monitoring of the treatment response and recurrence of haematological neoplasia.

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Section: Discussionmentioning

confidence: 94%