Prevalence of Obesity in Newly Onset Diabetes Mellitus and Its Relationship with Uric Acid: An Indian Cross-Sectional Study

Abstract

Introduction Prevalence of obesity is high in diabetes mellitus (DM) and is associated with hyperuricemia (HU), hypertension, metabolic syndrome, cardiovascular disease and dyslipidemia. In obesity, elevated serum uric acid (SUA) has been shown to be associated in many studies from different countries, but data from India are lacking. The aim of the present study is to know the prevalence of obesity and to know the relationship between obesity and SUA in newly onset DM. Methods In this cross-sectional study from India, 402 consecutive newly onset diabetic patients (male: 284; female: 118) were enrolled. All patients were grouped into four based on BMI (body mass index): underweight (<18.5 kg/m 2 ), normal weight (18.5–23 kg/m 2) , overweight (>23-27.5 kg/m 2 ), and obese (>27.5 kg/m 2 ). All participants were grouped into four quartiles based on SUA (Q1: <4.23; Q2: ≥4.24–5.19; Q3: ≥5.20–6.16; Q4: >6.16). Results The mean age, BMI and SUA of the participants were 46.20±0.52 years, 26.35±0.21 kg/m 2 and 5.24±0.007 mg/dl, respectively. Overall prevalence of generalized obesity, central obesity and hyperuricemia (HU) were 35.07%, 85.82% and 13.43%, respectively. The prevalence of generalized obesity increased across the SUA quartile. A multinomial logistic regression analysis showed that serum uric acid level was independently associated with generalized obesity (p<0.001). Conclusion This first report from India shows a significant positive association between SUA and generalized obesity among newly onset DM. Therefore, routine estimation of SUA is recommended in newly onset DM to prevent and treat HU and its related complications.

Prescribing patterns of antidiabetic drugs and glycaemic control in type 2 diabetes patients visiting tertiary care hospital based in Karachi, Pakistan

“…In 2023, a study conducted in India reported a mean BMI of 26.35±0.21 kg/m 2 in their newly onset diabetic patients with 141 participants being obese and 185 participants being overweight. 13 The population of males was greater than the females in our study reporting a ratio of 1:1. While the study in India reported a ratio of 0.96 with females being 51.11%.…”

Hyperuricemia and associated factors: The case of outpatients at the Bafoussam Regional Hospital‐ Cameroon, an analytical cross‐sectional study

“…5 Hyperuricemia is associated with obesity, hypertension, diabetes, dyslipidemia, metabolic syndrome, liver dysfunction, cardiovascular disease, and chronic kidney disease as reported by several authors even if the mechanisms remain to be elucidated. [13][14][15][16][17][18][19] Given the appearance of cardiovascular and renal comorbidities after long exposure to hyperuricemia, it is difficult to know whether hyperuricemia is a risk mark for nongouty disease or factors associated with its. 2 Hyperuricemia constitutes a major public health issue due to its implication in many chronic diseases and metabolic syndromes.…”