Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls

Tian, Yang; Wang, Dongmei; Wei, Gao-Xia; Wang, Jiesi; Zhou, Huixia; Xu, Hang; Dai, Qilong; Xiu, Meihong; Chen, Dachun; Wang, Li

doi:10.1007/s00213-020-05727-1

Cited by 21 publications

(29 citation statements)

References 62 publications

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“…Previous studies have shown that there was no significant difference in the incidence of obesity in the first-episode untreated major depressive disorder (MDD) [ 3 ], bipolar disorder (BD) [ 4 ] and schizophrenia (SCZ)) [ 5 ] compared with healthy controls. However, after using psychotropic drugs for a period of time, the weight of patients would increase in varying degrees, even to the extent of obesity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolic indexes of obesity in patients with common mental disorders in stable stage

Xiao

Tan

et al. 2022

BMC Psychiatry

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Background Obesity is a serious worldwide public health problem, especially for people with mental disorders. Aim To explore the related factors of obesity by analyzing the metabolic indexes of patients with common mental disorders in stable stage. Methods Five hundred seventy-six subjects with major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ) were included, who received fixed drug dose and routine drug treatment for 2 years or more. Their venous blood was collected, and the blood metabolic indexes were analyzed. Results BD and SCZ are more prone to obesity than MDD. Multiple linear regression analysis showed that the value of BMI increased with the increase of age(B = 0.084, p < 0.001), TG(B = 0.355, p = 0.024), LDL(B = 0.697, p < 0.001), LDH(B = 0.011, p = 0.002), SCr(B = 0.051, p < 0.001), UA(B = 0.014, p < 0.001), HbA1c(B = 0.702, p = 0.004) and hsCRP(B = 0.101, p < 0.001). And It decreased with the increase of HDL(B = -1.493, p < 0.001). Discussion People with mental disorders should regularly check blood indicators and strengthen weight management to reduce the risk of obesity and promote their health.

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Section: Introductionmentioning

confidence: 99%

Metabolic indexes of obesity in patients with common mental disorders in stable stage

Xiao

Tan

et al. 2022

BMC Psychiatry

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“…A previous study has shown that there was no significant difference in the incidence of obesity in first-episode SC compared with HC (13). However, after using psychotropic drugs for a period of time, the weight of patients would increase to varying degrees, even to the extent of obesity (10,14).…”

Section: Discussionmentioning

confidence: 93%

Does Schizophrenia Itself Cause Obesity?

et al. 2022

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BackgroundSchizophrenia (SC) is considered the most serious of all mental disorders. Some antipsychotics are associated with weight gain and metabolic abnormalities. Whether SC itself causes obesity remains uncertain.MethodsWe collected 185 first-episode drug-naive SC and 59 healthy controls (HCs) from the Third People’s Hospital of Foshan, Guangdong, China, and distinguished their course of disease in order to understand the body mass index (BMI) and body fat metabolism of SC.ResultsWe found that excluding the drug factors, the longer the course of SC, the more obvious the increase of BMI and the higher the proportion of obesity. BMI was positively correlated with age, course of disease, fasting blood glucose (FBG), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC), and negatively correlated with high-density lipoprotein (HDL). The results of regression analysis were further proof that age (B = 0.094, p < 0.001), duration (B = 0.081, p = 0.002), FBG (B = 0.987, p = 0.004), and TG (B = 0.918, p = 0.002) were the risk factors for the increase of BMI. HDL (B = –2.875, p < 0.001) was the protective factor.ConclusionSC itself can increase BMI and easily lead to obesity. We should pay more attention to the monitoring of blood metabolism indicators, so as to reduce the risk of obesity and improve the quality of life of patients.

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“…Clinically, overweight/obesity is particularly prevalent in SZ, with nearly 40–60% of patients with SZ being overweight or obese, a rate significantly higher than that in the general population (20–40%) [ 6 – 9 ]. Among the factors contributing to this high prevalence, a complex interplay between the adverse effects of antipsychotics, unhealthy lifestyle, and pathophysiological mechanisms inherent in SZ, have been the most cited explanations [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia

Dai²,

Aizezi³

et al. 2022

BMC Psychiatry

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Background Both schizophrenia (SZ) and overweight/obesity (OWB) have shown some structural alterations in similar brain regions. As higher body mass index (BMI) often contributes to worse psychiatric outcomes in SZ, this study was designed to examine the effects of OWB on gray matter volume (GMV) in patients with SZ. Methods Two hundred fifty subjects were included and stratified into four groups (n = 69, SZ patients with OWB, SZ-OWB; n = 74, SZ patients with normal weight, SZ-NW; n = 54, healthy controls with OWB, HC-OWB; and n = 53, HC with NW, HC-NW). All participants were scanned using high-resolution T1-weighted sequence. The whole-brain voxel-based morphometry was applied to examine the GMV alterations, and a 2 × 2 full factorial analysis of variance was performed to identify the main effects of diagnosis (SZ vs HC), BMI (NW vs OWB) factors, and their interactions. Further, the post hoc analysis was conducted to compare the pairwise differences in GMV alterations. Results The main effects of diagnosis were located in right hippocampus, bilateral insula, rectus, median cingulate/paracingulate gyri and thalamus (SZ < HC); while the main effects of BMI were displayed in right amygdala, left hippocampus, bilateral insula, left lingual gyrus, and right superior temporal gyrus (OWB < NW). There were no significant diagnosis-by-BMI interaction effects in the present study, but the results showed that both SZ and OWB were additively associated with lower GMV in bilateral insula. Moreover, mediation analyses revealed the indirect effect of BMI on negative symptom via GMV reduction in bilateral insula. Conclusion This study further supports that higher BMI is associated with lower GMV, which may increase the risk of unfavourable disease courses in SZ.

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Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls

Cited by 21 publications

References 62 publications

Metabolic indexes of obesity in patients with common mental disorders in stable stage

Metabolic indexes of obesity in patients with common mental disorders in stable stage

Does Schizophrenia Itself Cause Obesity?

Gray matter reduction in bilateral insula mediating adverse psychiatric effects of body mass index in schizophrenia

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