Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

Risk factors for development of nonalcoholic fatty liver disease after pancreatoduodenectomy

“…Although there is overwhelming evidence of an association between insulin resistance and the prevalence of conventional NAFLD,24 the value of HOMA‐R was not significantly different between the two groups and the prevalence of accompanying DM was paradoxically less in the NAFLD group than in the controls at 1 month after PD in this series. This is possibly because the probability of progressive stages of NAFLD, such as non‐alcoholic steatohepatitis (NASH) and liver fibrosis increases with the presence of impaired glucose tolerance 25.…”

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

“…4 In a study consisting of nearly 400 middle aged individuals, the prevalence of NAFLD defined by ultrasonography was 46% and the prevalence of histologically confirmed NASH was 12.2%. 14 In the Dallas Heart Study, when assessed by MR spectroscopy the prevalence of NAFLD in the general population was 31%. 15 The prevalence of suspected NAFLD when estimated using aminotransferases alone without imaging or histology ranged between 7% and 11%, but aminotransferases can be normal in individuals with NAFLD.…”

Hepatic fibrosis developing in morbid obesity independent of steatohepatitis: new mechanism or the Rube Goldberg machine?

“…NAFLD encompasses a broad spectrum of pathology from steatosis alone, to nonalcoholic steatohepatitis (NASH), with or without fibrosis. As the prevalence of steatosis and NASH was recently estimated to be 46 and 12 % [1], respectively, understanding the mechanism of fibrosis that leads to hepatic complications is crucial. In the current issue of Hepatology International, Ciupinska-Kajor et al [2] present data suggesting the mechanism of fibrosis in NAFLD might differ based on the degree of adiposity, and that early angiogenesis could be the distinguishing feature.…”