Hepatic fibrosis developing in morbid obesity independent of steatohepatitis: new mechanism or the Rube Goldberg machine?

Kallwitz, Eric R.

doi:10.1007/s12072-012-9358-3

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…In the undirected graphical model, T2DM and insulin resistance are directly associated with hepatic fibrosis. These findings are supported by previous studies 11,43,44 and our results, as mentioned above. Moreover, the serum LDL cholesterol level was identified as a direct factor associated with fibrosis.…”

Section: Discussionsupporting

confidence: 94%

“…The prevalence of T2DM and HOMA‐IR values was higher in the F2/3 group than in the F0/1 group. Hepatic fibrosis is known to develop independent of steatohepatitis in patients with morbid obesity 43 . Aller et al.…”

Section: Discussionmentioning

confidence: 99%

“…Hepatic fibrosis is known to develop independent of steatohepatitis in patients with morbid obesity. 43 Aller et al reported that insulin resistance determined by HOMA-IR is associated with high-grade hepatic fibrosis in patients with morbid obesity. 11 In addition, hyperglycemia and insulin directly promote fibrogenesis through activation of connective tissue growth factor in hepatic stellate cells.…”

Section: Discussionmentioning

confidence: 99%

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Metabolic dysfunction‐associated fatty liver disease directly related to liver fibrosis independent of insulin resistance, hyperlipidemia, and alcohol intake in morbidly obese patients

Inamine

Kage

Akiba

et al. 2022

Hepatology Research

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Aim: Hepatic fibrosis is associated with various factors, including metabolic dysfunction-associated fatty liver disease (MAFLD), insulin resistance, and alcohol intake in patients with morbid obesity. We investigated factors directly associated with hepatic fibrosis in patients with morbid obesity using a graphical model. Methods:We enrolled 134 consecutive patients with morbid obesity who underwent liver biopsy during sleeve gastrectomy (median age 43.5 years; MAFLD 78.4%; homeostasis model assessment of insulin resistance [HOMA-IR] 5.97; >20 g/day alcohol intake 14.2%). Patients were classified into none/mild (F0/1; n = 77) or significant/advanced fibrosis (F2/3; n = 57) groups, based on histology. Factors associated with F2/3 were analyzed using logistic regression analysis and a graphical model.Results: F2/3 was observed in 42.5% of the enrolled patients. The prevalence of MAFLD and HOMA-IR values were significantly higher in the F2/3 group than in the F0/1 group; however, no significant difference in alcohol intake was observed between the two groups. On logistic regression analysis, MAFLD, but not HOMA-IR or alcohol intake, was the only independent factor associated with F2/3 (odds ratio

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%