Prevalence of non‐ulcer dyspepsia in the Japanese population

Hirakawa, K.; Adachi, Kyoichi; Amano, Kazutoshi; Katsube, Tomoko; Ishihara, Shunji; Fukuda, Ryo; Yamashita, Yuichi; Shiozawa, Shunichi; Watanabe, Makoto; Kinoshita, Yoshikazu

doi:10.1046/j.1440-1746.1999.02012.x

Cited by 51 publications

(34 citation statements)

References 23 publications

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“…While this result included symptoms from patients with organic disease such as PU and gastroesophageal reflux disease, the prevalence of FD in the general population has been reported in other studies: 11.5-14.5% in Western countries [12] and 13% in Japan [13]. Hirakawa et al suggested that the prevalence of non-ulcer dyspepsia, consisting of FD and reflux-like dyspepsia, was 17% among the Japanese population [14]. Thus, patients with upper abdominal symptoms are very common in Japan as well as in Western countries.…”

Section: Discussionmentioning

confidence: 71%

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Adachi

Matsumori

Fujisawa

et al. 2006

J. Clin. Biochem. Nutr.

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Summary Objective: A number of clinical trials have reported that proton-pump inhibitors are efficacious in the treatment of upper abdominal symptoms, but most of these trials have been carried out in Caucasians. This study investigated the type of upper abdominal symptoms reported by Japanese patients with reflux esophagitis and the efficacy of omeprazole for treating their symptoms.Methods: A total of 234 patients aged ≥20 years with grade A to D reflux esophagitis were enrolled in this multicenter, open study. Patients received omeprazole 10 or 20 mg/day for 4 weeks. Symptom and quality of life questionnaires were administered at baseline, week 2 and week 4.Results: Among the 221 evaluable patients, almost 70% reported reflux-type symptoms (e.g. regurgitation and heartburn). Ulcer-and dysmotility-type symptoms (e.g. stomach pain and belching) were also common, occurring in 38-62% of patients. After 4 weeks of omeprazole *To whom correspondence should be addressed. Tel: +81-853-20-2190 Fax: +81-853-20-2187 E-mail: kadachi@med.shimane-u.ac.jp Abbreviations: ARD, acid-related disease; FD, functional dyspepsia; GSRS, Gastrointestinal Symptoms Rating Scale; PPIs, proton pump inhibitors; PU, peptic ulcer; QOL,quality of life; RE, reflux esophagitis; SD, standard deviation. Conclusion: Reflux-type symptoms as well as ulcer-and dysmotility-type symptoms were seen frequently in Japanese patients with reflux esophagitis. However, omeprazole improved all symptom types and quality of life in this patient population.

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Section: Discussionmentioning

confidence: 71%

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Adachi

Matsumori

Fujisawa

et al. 2006

J. Clin. Biochem. Nutr.

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“…In a Norwegian (one municipality based survey) the dyspepsia was recorded in 14.7% [5]. In Japan (one city based study) the prevalence of functional dyspepsia recorded during the screening program of carcinoma of breast was recorded to be 17% [6]. In Balochistan a hospital based study revealed that the functional dyspepsia was recorded in 38.9%.…”

Section: Prevalence Of Functional Dyspepsiamentioning

confidence: 97%

“…The previous record of functional dyspepsia in Balochistan showed the most common age group was 31-40 years [7]. The functional dyspepsia in Chinese population was recorded in majority of people between the ages of 41-50 years [11] In Japan the most common age group recorded was 50-59 years [6].…”

Section: Demography Of Functional Dyspepsiamentioning

confidence: 99%

Functional Dyspepsia: An Unresolved Issue

Mehboob¹

2015

Intern Med

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Functional dyspepsia (FD) is one of the commonest medical problems which affect the quality of life. Due to its global presentation variety of symptoms recorded, therefore no global consensus developed. The recorded symptoms of functional dyspepsia are nonspecific and the pathophysiology is diverse. The role of genetics in the susceptibility of FD is still not well established. The last Rome III criteria defined the FD as symptoms of epigastric pain or discomfort, early satiety and postprandial fullness with in the last three months with symptoms not less than six months. Patient cannot have any evidence of structural disease and predominant Gastro esophageal reflux symptoms. Failure to respond to 'test and treat approach' is also categorize as FD. A universally effective treatment for functional dyspepsia remains elusive. The purpose of this paper is to highlight the details in perspective of functional dyspepsia.

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“…Peak FD was found to be 41-50 years among Chinese population. 26,27 It is > 40 years in Indian population. 28 Peak prevalence of UD has been found to be 45-54 years in Canadian survey.…”

Section: 16mentioning

confidence: 99%

Diagnosis of Functional Dyspepsia on the basis of Rome III clinical diagnostic criteria in a tertiary care hospital: A cross-sectional observational study

et al. 2018

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Background: Though functional dyspepsia (FD) is often a diagnosis of exclusion, whether minor mucosal gut pathology represents organic disease or FD, it still remains controversial. Aims and Objectives: The present study has been conducted to determine the accuracy of symptom based diagnosis of FD based on Rome III diagnostic criteria in a tertiary care center. Materials and Methods: Total 140 patients aged between 18-55 years of both sexes with upper abdominal symptoms without known or post investigational organic diseases, were included in this study. Patients fulfilling the Rome III criteria were diagnosed as FD and undergone upper GI endoscopy (UGIE). Those devoid of organic lesions were confirmed as 'true FD'. Results: Out of 140 study patients, 100 patients fulfilled Rome III criteria (clinical FD) out of which 77 were confirmed as 'true FD' after UGIE with an accuracy of 83.57 %. Conclusion: Rome III clinical criteria can be applied to diagnose FD in a tertiary care center with some limitations. The authors suggest some modification of Rome III criteria.

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Prevalence of non‐ulcer dyspepsia in the Japanese population

Abstract: This study clarified that NUD is also one of the most prevalent disorders in the Japanese, although its characteristics may be somewhat different from those in Western countries.

Cited by 51 publications

References 23 publications

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Functional Dyspepsia: An Unresolved Issue

Diagnosis of Functional Dyspepsia on the basis of Rome III clinical diagnostic criteria in a tertiary care hospital: A cross-sectional observational study

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